SG10202010735PA - Tau-binding antibodies - Google Patents
Tau-binding antibodiesInfo
- Publication number
- SG10202010735PA SG10202010735PA SG10202010735PA SG10202010735PA SG10202010735PA SG 10202010735P A SG10202010735P A SG 10202010735PA SG 10202010735P A SG10202010735P A SG 10202010735PA SG 10202010735P A SG10202010735P A SG 10202010735PA SG 10202010735P A SG10202010735P A SG 10202010735PA
- Authority
- SG
- Singapore
- Prior art keywords
- tau
- binding antibodies
- antibodies
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15175522 | 2015-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202010735PA true SG10202010735PA (en) | 2020-11-27 |
Family
ID=53524640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202010735PA SG10202010735PA (en) | 2015-07-06 | 2016-07-05 | Tau-binding antibodies |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US10287343B2 (fr) |
| EP (1) | EP3319983A1 (fr) |
| JP (3) | JP6630426B2 (fr) |
| KR (1) | KR20180025962A (fr) |
| CN (1) | CN107849104B (fr) |
| AR (1) | AR105267A1 (fr) |
| AU (1) | AU2016289755C1 (fr) |
| BR (1) | BR112017028102A2 (fr) |
| CA (1) | CA2991451A1 (fr) |
| CL (1) | CL2018000043A1 (fr) |
| CO (1) | CO2017012971A2 (fr) |
| EA (1) | EA037092B1 (fr) |
| EC (1) | ECSP18000887A (fr) |
| HK (1) | HK1246804A1 (fr) |
| IL (1) | IL256685B (fr) |
| MA (2) | MA41670A1 (fr) |
| MX (1) | MX2017015817A (fr) |
| MY (1) | MY193677A (fr) |
| NZ (1) | NZ738058A (fr) |
| PE (1) | PE20180481A1 (fr) |
| PH (1) | PH12017502207A1 (fr) |
| SG (1) | SG10202010735PA (fr) |
| TN (1) | TN2017000539A1 (fr) |
| TW (1) | TWI745295B (fr) |
| UA (1) | UA124616C2 (fr) |
| UY (1) | UY36773A (fr) |
| WO (1) | WO2017005734A1 (fr) |
| ZA (1) | ZA201800027B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6793134B2 (ja) | 2015-06-05 | 2020-12-02 | ジェネンテック， インコーポレイテッド | 抗ｔａｕ抗体及び使用方法 |
| BR112017028102A2 (pt) | 2015-07-06 | 2018-09-04 | Ucb Biopharma Sprl | anticorpos de ligação à tau |
| PE20180499A1 (es) | 2015-07-06 | 2018-03-09 | Ucb Biopharma Sprl | Anticuerpos de union a tau |
| AR110321A1 (es) | 2016-12-07 | 2019-03-20 | Genentech Inc | Anticuerpos antitau y métodos de uso |
| JP2020511937A (ja) | 2016-12-07 | 2020-04-23 | ジェネンテック， インコーポレイテッド | 抗ｔａｕ抗体及び使用方法 |
| WO2018152359A1 (fr) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Anticorps anti-tau et leurs procédés d'utilisation |
| JP2018139530A (ja) | 2017-02-27 | 2018-09-13 | 帝人ファーマ株式会社 | 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤 |
| TWI809562B (zh) | 2017-10-16 | 2023-07-21 | 日商衛材R&D企管股份有限公司 | 抗tau抗體及其用途 |
| WO2020120644A1 (fr) * | 2018-12-13 | 2020-06-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nouvel anticorps à domaine unique d'épitope dirigé contre tau svqivykpv |
| US20220299527A1 (en) * | 2019-08-13 | 2022-09-22 | Washington University | Methods to detect mtbr tau isoforms and use thereof |
| WO2021163031A1 (fr) | 2020-02-12 | 2021-08-19 | Eli Lilly And Company | Cristallisation d'anticorps ou de fragments de liaison à l'antigène |
| MX2022016322A (es) | 2020-06-25 | 2023-01-24 | Merck Sharp & Dohme Llc | Anticuerpos de alta afinidad dirigidos a tau fosforilada en la serina 413. |
| WO2023092004A1 (fr) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions et méthodes pour le traitement de troubles liés à tau |
Family Cites Families (51)
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|---|---|---|---|---|
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| DK336987D0 (da) | 1987-07-01 | 1987-07-01 | Novo Industri As | Immobiliseringsmetode |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8719042D0 (en) | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
| GB8720833D0 (en) | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
| GB8907617D0 (en) | 1989-04-05 | 1989-05-17 | Celltech Ltd | Drug delivery system |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| GB9112536D0 (en) | 1991-06-11 | 1991-07-31 | Celltech Ltd | Chemical compounds |
| GB9120467D0 (en) | 1991-09-26 | 1991-11-06 | Celltech Ltd | Anti-hmfg antibodies and process for their production |
| FR2716640B1 (fr) | 1994-02-28 | 1996-05-03 | Procedes Machines Speciales | Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion. |
| US6372716B1 (en) | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| GB9625640D0 (en) | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
| US6566329B1 (en) | 1999-06-28 | 2003-05-20 | Novo Nordisk A/S | Freeze-dried preparation of human growth hormone |
| AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
| US6908963B2 (en) | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| SI1644412T2 (sl) | 2003-07-01 | 2018-11-30 | Ucb Biopharma Sprl | Modificirani fab fragmenti protiteles |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0411186D0 (en) | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| CN1721437A (zh) * | 2004-07-13 | 2006-01-18 | 中南大学 | 一种与Tau蛋白相关的多肽抗原及抗体 |
| EP1928506A4 (fr) | 2005-08-19 | 2009-10-21 | Abbott Lab | Immunoglobuline a deux domaines variables et utilisations de celle-ci |
| GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
| GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
| GB0624500D0 (en) * | 2006-12-07 | 2007-01-17 | Istituto Superiore Di Sanito | A novel passive vaccine for candida infections |
| CN101842387B (zh) | 2007-09-26 | 2014-05-07 | Ucb医药有限公司 | 双特异性抗体融合物 |
| CN101307108B (zh) * | 2008-06-25 | 2012-04-04 | 南京川博生物技术有限公司 | 抗磷酸化Tau蛋白抗体及其在AD症异常磷酸化Tau蛋白水平测定上的用途 |
| CN105601745B (zh) | 2008-09-26 | 2020-09-08 | Ucb医药有限公司 | 生物产品 |
| MX2011004017A (es) | 2008-10-15 | 2011-06-24 | Angiochem Inc | Conjugados de agonistas glp-1 y usos de los mismos. |
| CA2745524C (fr) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugues de neurotensine ou d'analogues de neurotensine et leurs applications |
| JP2012510797A (ja) | 2008-12-05 | 2012-05-17 | アンジオケム インコーポレーテッド | レプチンおよびレプチン類似体コンジュゲートならびにそれらの使用 |
| US8609097B2 (en) | 2009-06-10 | 2013-12-17 | Hoffmann-La Roche Inc. | Use of an anti-Tau pS422 antibody for the treatment of brain diseases |
| WO2011030107A1 (fr) | 2009-09-10 | 2011-03-17 | Ucb Pharma S.A. | Anticorps multivalents |
| EP2486061A4 (fr) | 2009-10-06 | 2013-08-28 | Angiochem Inc | Compositions et procédés pour transporter des agents thérapeutiques |
| MX338421B (es) | 2010-10-07 | 2016-04-15 | Ac Immune Sa | Anticuerpos fosfoespecificos que reconocen la proteina tau. |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| UA115657C2 (uk) | 2011-09-19 | 2017-12-11 | Аксон Ньюросайєнс Сє | Виділене антитіло, яке зв'язується з одним або декількома епітопами тау, фармацевтична композиція, що його містить, спосіб лікування та спосіб діагностики хвороби альцгеймера на основі виділеного антитіла |
| DK2776466T3 (da) | 2011-11-11 | 2017-11-20 | Ucb Biopharma Sprl | Albuminbindende antistoffer og bindingsfragmenter deraf |
| MY178142A (en) * | 2011-12-20 | 2020-10-05 | Janssen Biotech Inc | Anti-phf-tau antibodies and their uses |
| JP6345655B2 (ja) | 2012-07-03 | 2018-06-20 | ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | タウに対する抗体 |
| ME03667B (fr) * | 2012-08-16 | 2020-10-20 | Ipierian Inc | Méthodes de traitement d'une tauopathie |
| ES2816700T3 (es) | 2012-12-21 | 2021-04-05 | Biogen Ma Inc | Anticuerpos anti-tau humanos |
| CA2874083C (fr) * | 2014-12-05 | 2024-01-02 | Universite Laval | Polypeptides liant le tdp-43 utiles pour le traitement de maladies neurodegeneratives |
| BR112017028102A2 (pt) | 2015-07-06 | 2018-09-04 | Ucb Biopharma Sprl | anticorpos de ligação à tau |
| PE20180499A1 (es) | 2015-07-06 | 2018-03-09 | Ucb Biopharma Sprl | Anticuerpos de union a tau |
-
2016
- 2016-07-05 BR BR112017028102A patent/BR112017028102A2/pt active Search and Examination
- 2016-07-05 EA EA201890172A patent/EA037092B1/ru not_active IP Right Cessation
- 2016-07-05 UA UAA201711739A patent/UA124616C2/uk unknown
- 2016-07-05 MA MA41670A patent/MA41670A1/fr unknown
- 2016-07-05 EP EP16734676.6A patent/EP3319983A1/fr active Pending
- 2016-07-05 KR KR1020187003689A patent/KR20180025962A/ko not_active Application Discontinuation
- 2016-07-05 NZ NZ738058A patent/NZ738058A/en unknown
- 2016-07-05 TN TNP/2017/000539A patent/TN2017000539A1/en unknown
- 2016-07-05 MA MA042377A patent/MA42377A/fr unknown
- 2016-07-05 JP JP2018500423A patent/JP6630426B2/ja active Active
- 2016-07-05 MY MYPI2018700043A patent/MY193677A/en unknown
- 2016-07-05 PE PE2017002750A patent/PE20180481A1/es unknown
- 2016-07-05 US US15/742,087 patent/US10287343B2/en active Active
- 2016-07-05 CA CA2991451A patent/CA2991451A1/fr active Pending
- 2016-07-05 WO PCT/EP2016/065813 patent/WO2017005734A1/fr active Application Filing
- 2016-07-05 CN CN201680039795.4A patent/CN107849104B/zh active Active
- 2016-07-05 AU AU2016289755A patent/AU2016289755C1/en active Active
- 2016-07-05 MX MX2017015817A patent/MX2017015817A/es unknown
- 2016-07-05 SG SG10202010735PA patent/SG10202010735PA/en unknown
- 2016-07-06 AR ARP160102045A patent/AR105267A1/es unknown
- 2016-07-06 UY UY0001036773A patent/UY36773A/es not_active Application Discontinuation
- 2016-07-06 TW TW105121455A patent/TWI745295B/zh active
-
2017
- 2017-12-04 PH PH12017502207A patent/PH12017502207A1/en unknown
- 2017-12-18 CO CONC2017/0012971A patent/CO2017012971A2/es unknown
-
2018
- 2018-01-01 IL IL256685A patent/IL256685B/en unknown
- 2018-01-03 ZA ZA2018/00027A patent/ZA201800027B/en unknown
- 2018-01-05 CL CL2018000043A patent/CL2018000043A1/es unknown
- 2018-01-05 EC ECIEPI2018887A patent/ECSP18000887A/es unknown
- 2018-05-10 HK HK18106080.8A patent/HK1246804A1/zh unknown
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2019
- 2019-05-13 US US16/409,945 patent/US10889640B2/en active Active
- 2019-12-06 JP JP2019220807A patent/JP7100008B2/ja active Active
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2020
- 2020-12-29 US US17/136,189 patent/US11732034B2/en active Active
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2022
- 2022-06-30 JP JP2022105415A patent/JP7413448B2/ja active Active
-
2023
- 2023-06-30 US US18/344,945 patent/US20230416350A1/en active Pending
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