SG10202002556QA - Mercaptopurine ribonucleoside analogues for altering telomerase mediated telomere - Google Patents
Mercaptopurine ribonucleoside analogues for altering telomerase mediated telomereInfo
- Publication number
- SG10202002556QA SG10202002556QA SG10202002556QA SG10202002556QA SG10202002556QA SG 10202002556Q A SG10202002556Q A SG 10202002556QA SG 10202002556Q A SG10202002556Q A SG 10202002556QA SG 10202002556Q A SG10202002556Q A SG 10202002556QA SG 10202002556Q A SG10202002556Q A SG 10202002556QA
- Authority
- SG
- Singapore
- Prior art keywords
- ribonucleoside analogues
- mercaptopurine ribonucleoside
- altering
- mediated telomere
- telomerase mediated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Biochemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809575P | 2013-04-08 | 2013-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202002556QA true SG10202002556QA (en) | 2020-04-29 |
Family
ID=50819958
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202002556QA SG10202002556QA (en) | 2013-04-08 | 2014-04-08 | Mercaptopurine ribonucleoside analogues for altering telomerase mediated telomere |
| SG11201508336TA SG11201508336TA (en) | 2013-04-08 | 2014-04-08 | Mercaptopurine ribonucleoside analogues for altering telomerase mediated telomere |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201508336TA SG11201508336TA (en) | 2013-04-08 | 2014-04-08 | Mercaptopurine ribonucleoside analogues for altering telomerase mediated telomere |
Country Status (14)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180036331A1 (en) * | 2016-03-24 | 2018-02-08 | The Board Of Regents Of The University Of Texas System | Treatment of drug resistant proliferative diseases with telomerase mediated telomere altering compounds |
| US20190298751A1 (en) * | 2016-05-27 | 2019-10-03 | The Board Of Regents Of The University Of Texas System | 6-thio-2'-deoxyguanosine (6-thio-dg) results in telomerase dependent telomere dysfunction and cell death in various models of therapy-resistant cancer cells |
| WO2019183482A1 (en) * | 2018-03-22 | 2019-09-26 | The Board Of Regents Of The University Of Texas System | USE OF 6-THIO-dG TO TREAT THERAPY-RESISTANT TELOMERASEPOSITIVE PEDIATRIC BRAIN TUMORS |
| AU2019208197B2 (en) | 2018-07-31 | 2025-05-29 | Howmedica Osteonics Corp. | Fixation devices and prostheses for soft tissue connection to the same |
| EP3866932A4 (en) * | 2018-10-17 | 2022-11-30 | Xibin Liao | 6-mercaptopurine nucleoside analogues |
| USD1046142S1 (en) | 2019-07-24 | 2024-10-08 | Howmedica Osteonics Corp. | Proximal tibial prosthesis |
| CN112898292A (zh) | 2019-12-03 | 2021-06-04 | 微境生物医药科技(上海)有限公司 | 新型极光激酶抑制剂及其用途 |
| JP2023517671A (ja) | 2020-03-13 | 2023-04-26 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | ６－チオ－ｄＧ、チェックポイント阻害剤および放射線療法を使用するがんの逐次処置 |
| WO2024188308A1 (zh) * | 2023-03-14 | 2024-09-19 | 上海华汇拓医药科技有限公司 | 一类核苷类似物及其应用 |
| WO2024188302A1 (zh) * | 2023-03-14 | 2024-09-19 | 上海华汇拓医药科技有限公司 | 一类靶向端粒酶的核苷类似物及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57209226A (en) * | 1981-06-18 | 1982-12-22 | Yamasa Shoyu Co Ltd | Antitumor activity intensifier |
| CA2444071C (en) | 1991-02-08 | 2008-10-07 | Wellstat Therapeutics Corporation | Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis |
| JP2008538771A (ja) | 2005-04-25 | 2008-11-06 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー， アカデミー オブ サイエンシズ オブ ザ チェコ リパブリック | テロメラーゼのプロセッシビティーを向上させるための化合物の使用 |
| CN101220071B (zh) * | 2008-01-17 | 2011-04-06 | 南京长澳医药科技有限公司 | 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物 |
| US20100323979A1 (en) * | 2009-06-16 | 2010-12-23 | Weis-Amon Angelika B | Methods and compositions for inhibiting proliferation of aneuploid cells |
-
2014
- 2014-04-08 RU RU2015147555A patent/RU2713555C2/ru active
- 2014-04-08 HK HK16107437.8A patent/HK1219418A1/zh unknown
- 2014-04-08 US US14/247,967 patent/US10463685B2/en active Active
- 2014-04-08 MX MX2015014159A patent/MX387008B/es unknown
- 2014-04-08 EP EP20155920.0A patent/EP3682888B1/en active Active
- 2014-04-08 AU AU2014251093A patent/AU2014251093B2/en not_active Ceased
- 2014-04-08 SG SG10202002556QA patent/SG10202002556QA/en unknown
- 2014-04-08 WO PCT/US2014/033330 patent/WO2014168947A2/en active Application Filing
- 2014-04-08 KR KR1020157031880A patent/KR20150143587A/ko not_active Ceased
- 2014-04-08 BR BR112015025206A patent/BR112015025206A2/pt not_active Application Discontinuation
- 2014-04-08 JP JP2016507608A patent/JP6525956B2/ja active Active
- 2014-04-08 EP EP14726468.3A patent/EP2983675A2/en not_active Withdrawn
- 2014-04-08 NZ NZ713498A patent/NZ713498A/en not_active IP Right Cessation
- 2014-04-08 CN CN201480032692.6A patent/CN105338987A/zh active Pending
- 2014-04-08 CA CA2907924A patent/CA2907924C/en active Active
- 2014-04-08 CN CN201910445731.XA patent/CN110339203A/zh active Pending
- 2014-04-08 SG SG11201508336TA patent/SG11201508336TA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2907924A1 (en) | 2014-10-16 |
| US10463685B2 (en) | 2019-11-05 |
| WO2014168947A9 (en) | 2014-12-31 |
| BR112015025206A2 (pt) | 2017-07-18 |
| WO2014168947A3 (en) | 2015-02-19 |
| JP2016516773A (ja) | 2016-06-09 |
| HK1219418A1 (zh) | 2017-04-07 |
| CA2907924C (en) | 2022-10-25 |
| MX2015014159A (es) | 2016-06-21 |
| AU2014251093A1 (en) | 2015-10-15 |
| US20140303239A1 (en) | 2014-10-09 |
| EP3682888B1 (en) | 2025-06-11 |
| RU2015147555A (ru) | 2017-05-15 |
| SG11201508336TA (en) | 2015-11-27 |
| WO2014168947A2 (en) | 2014-10-16 |
| MX387008B (es) | 2025-03-19 |
| KR20150143587A (ko) | 2015-12-23 |
| CN105338987A (zh) | 2016-02-17 |
| CN110339203A (zh) | 2019-10-18 |
| NZ713498A (en) | 2017-07-28 |
| RU2713555C2 (ru) | 2020-02-05 |
| EP2983675A2 (en) | 2016-02-17 |
| NZ732228A (en) | 2020-11-27 |
| AU2014251093B2 (en) | 2017-06-15 |
| JP6525956B2 (ja) | 2019-06-05 |
| EP3682888A1 (en) | 2020-07-22 |
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