SG10201807904RA - Mitochondria-Targeted Dicarbonyl Sequestering Compounds - Google Patents
Mitochondria-Targeted Dicarbonyl Sequestering CompoundsInfo
- Publication number
- SG10201807904RA SG10201807904RA SG10201807904RA SG10201807904RA SG10201807904RA SG 10201807904R A SG10201807904R A SG 10201807904RA SG 10201807904R A SG10201807904R A SG 10201807904RA SG 10201807904R A SG10201807904R A SG 10201807904RA SG 10201807904R A SG10201807904R A SG 10201807904RA
- Authority
- SG
- Singapore
- Prior art keywords
- compounds
- mitochondria
- targeted
- dicarbonyl sequestering
- salts
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 230000014759 maintenance of location Effects 0.000 title abstract 3
- 125000004989 dicarbonyl group Chemical group 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 238000004949 mass spectrometry Methods 0.000 abstract 2
- KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000003345 hyperglycaemic effect Effects 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002438 mitochondrial effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Environmental Sciences (AREA)
- Endocrinology (AREA)
- Dentistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1320636.2A GB201320636D0 (en) | 2013-11-22 | 2013-11-22 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201807904RA true SG10201807904RA (en) | 2018-10-30 |
Family
ID=49918047
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201603485TA SG11201603485TA (en) | 2013-11-22 | 2014-11-21 | Mitochondria-targeted dicarbonyl sequestering compounds |
| SG10201807904RA SG10201807904RA (en) | 2013-11-22 | 2014-11-21 | Mitochondria-Targeted Dicarbonyl Sequestering Compounds |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201603485TA SG11201603485TA (en) | 2013-11-22 | 2014-11-21 | Mitochondria-targeted dicarbonyl sequestering compounds |
Country Status (12)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110114365B (zh) * | 2016-12-29 | 2022-12-13 | 波尔图大学 | 羟基苯甲酸衍生物、方法及其用途 |
| JP6985730B2 (ja) * | 2017-11-17 | 2021-12-22 | 株式会社日立ハイテクサイエンス | 試料分析システム、表示方法及び試料分析方法 |
| KR101920902B1 (ko) * | 2017-12-27 | 2018-11-21 | 전남대학교 산학협력단 | 심혈관 질환 조기진단 pet 조영용 화합물 및 그의 용도 |
| WO2020036329A1 (ko) * | 2018-08-16 | 2020-02-20 | 숙명여자대학교산학협력단 | 미토콘드리아 내 nad(p)h 검출을 위한 형광 프로브 및 이를 이용한 검출방법 |
| BR112021014697A2 (pt) * | 2019-01-25 | 2021-09-28 | Mti Biotech, Inc. | Derivados de salicilamina fixados a trifenilfosfônio |
| CN113677202B (zh) * | 2019-01-25 | 2024-03-08 | 范德比尔特大学 | 靶向线粒体的异缩酮/isolevuglandin清除剂 |
| KR102596981B1 (ko) * | 2019-10-30 | 2023-10-31 | 주식회사 퓨전바이오텍 | 미토콘드리아 표적 화합물 및 이를 포함하는 노화 관련 질환의 치료 또는 예방을 위한 조성물 |
| EP4097115A4 (en) * | 2020-01-27 | 2024-03-13 | Vanderbilt University | ISOCETAL/ISOLEVUGLANDIN SENSORS TARGETING MITOCHONDRIA AND THEIR USES |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB926998A (en) * | 1960-04-25 | 1963-05-22 | Ici Ltd | New water-soluble azo dyestuffs containing phosphonium groups |
| JPS52806A (en) | 1975-02-20 | 1977-01-06 | Dai Ichi Kogyo Seiyaku Co Ltd | Preparation of ester |
| JPS6029391B2 (ja) | 1976-02-04 | 1985-07-10 | 富士写真フイルム株式会社 | ベンゾトリアゾ−ル化合物 |
| FR2776290B1 (fr) * | 1998-03-20 | 2001-08-10 | Oreal | Nouveaux composes cationiques, leur utilisation comme coupleurs pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture |
| FR2776289B1 (fr) * | 1998-03-20 | 2001-02-02 | Oreal | Composition de teinture d'oxydation contenant un coupleur cationique, procedes de teinture, nouveaux coupleurs cationiques |
| FR2788520B1 (fr) * | 1999-01-19 | 2003-02-28 | Oreal | Nouveaux colorants mono-benzeniques cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture |
| WO2002058659A1 (en) * | 2001-01-23 | 2002-08-01 | P&G-Clairol, Inc. | Couplers for oxidative coloration of hair |
| JP2006501248A (ja) * | 2002-09-02 | 2006-01-12 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | 多孔質材料の着色方法 |
| JPWO2006059423A1 (ja) * | 2004-12-02 | 2008-06-05 | 独立行政法人科学技術振興機構 | 過興奮性の細胞傷害によって生じる疾患を治療するための薬剤および方法 |
| US7956193B2 (en) * | 2007-05-04 | 2011-06-07 | University Of South Florida | Intramolecular C-H amination with sulfonyl azides |
| US8466140B2 (en) | 2007-09-10 | 2013-06-18 | University Of Massachusetts | Mitochondria-targeted anti-tumor agents |
| FR2984321A1 (fr) * | 2011-12-16 | 2013-06-21 | Oreal | Paraphenylenediamines cationiques, composition comprenant au moins de tels composes, procede de mise en oeuvre et utilisation |
| CN102617467A (zh) | 2012-02-21 | 2012-08-01 | 大连理工大学 | 一种检测一氧化氮的超高灵敏荧光探针 |
| FR2996552B1 (fr) * | 2012-08-17 | 2016-10-14 | Oreal | Composition tinctoriale comprenant un derive o-alkyle substitue de meta-phenylenediamine cationique |
-
2013
- 2013-11-22 GB GBGB1320636.2A patent/GB201320636D0/en not_active Ceased
-
2014
- 2014-11-21 SG SG11201603485TA patent/SG11201603485TA/en unknown
- 2014-11-21 CA CA2931000A patent/CA2931000A1/en not_active Abandoned
- 2014-11-21 ES ES14818889T patent/ES2802123T3/es active Active
- 2014-11-21 HK HK16114224.1A patent/HK1226079A1/zh unknown
- 2014-11-21 SG SG10201807904RA patent/SG10201807904RA/en unknown
- 2014-11-21 WO PCT/EP2014/075323 patent/WO2015075200A1/en active Application Filing
- 2014-11-21 EP EP19204357.8A patent/EP3623375A1/en not_active Withdrawn
- 2014-11-21 JP JP2016528880A patent/JP6661533B2/ja not_active Expired - Fee Related
- 2014-11-21 CN CN201480063625.0A patent/CN105873936B/zh not_active Expired - Fee Related
- 2014-11-21 US US15/037,941 patent/US9963474B2/en active Active
- 2014-11-21 AU AU2014351802A patent/AU2014351802B2/en not_active Ceased
- 2014-11-21 EP EP14818889.9A patent/EP3071582B1/en active Active
-
2016
- 2016-05-10 ZA ZA2016/03129A patent/ZA201603129B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201603129B (en) | 2018-12-19 |
| CA2931000A1 (en) | 2015-05-28 |
| JP6661533B2 (ja) | 2020-03-11 |
| HK1226079A1 (zh) | 2017-09-22 |
| ES2802123T3 (es) | 2021-01-15 |
| US9963474B2 (en) | 2018-05-08 |
| EP3071582A1 (en) | 2016-09-28 |
| JP2017504561A (ja) | 2017-02-09 |
| EP3071582B1 (en) | 2020-04-29 |
| NZ719705A (en) | 2021-09-24 |
| US20160289252A1 (en) | 2016-10-06 |
| WO2015075200A1 (en) | 2015-05-28 |
| GB201320636D0 (en) | 2014-01-08 |
| AU2014351802B2 (en) | 2019-10-03 |
| CN105873936A (zh) | 2016-08-17 |
| CN105873936B (zh) | 2018-09-14 |
| SG11201603485TA (en) | 2016-05-30 |
| AU2014351802A1 (en) | 2016-05-26 |
| EP3623375A1 (en) | 2020-03-18 |
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