SG10201708125PA - Inhibitors of metastasis - Google Patents

Inhibitors of metastasis

Info

Publication number
SG10201708125PA
SG10201708125PA SG10201708125PA SG10201708125PA SG10201708125PA SG 10201708125P A SG10201708125P A SG 10201708125PA SG 10201708125P A SG10201708125P A SG 10201708125PA SG 10201708125P A SG10201708125P A SG 10201708125PA SG 10201708125P A SG10201708125P A SG 10201708125PA
Authority
SG
Singapore
Prior art keywords
metastasis
inhibitors
Prior art date
Application number
SG10201708125PA
Other languages
English (en)
Inventor
Indu Parikh
Kenneth B Adler
Original Assignee
Biomarck Pharmaceuticals Ltd
Univ North Carolina State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarck Pharmaceuticals Ltd, Univ North Carolina State filed Critical Biomarck Pharmaceuticals Ltd
Publication of SG10201708125PA publication Critical patent/SG10201708125PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • C12N2310/141MicroRNAs, miRNAs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
SG10201708125PA 2013-04-05 2014-04-07 Inhibitors of metastasis SG10201708125PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361808966P 2013-04-05 2013-04-05

Publications (1)

Publication Number Publication Date
SG10201708125PA true SG10201708125PA (en) 2017-11-29

Family

ID=51654619

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201708125PA SG10201708125PA (en) 2013-04-05 2014-04-07 Inhibitors of metastasis
SG11201508249WA SG11201508249WA (en) 2013-04-05 2014-04-07 Inhibitors of metastasis

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201508249WA SG11201508249WA (en) 2013-04-05 2014-04-07 Inhibitors of metastasis

Country Status (20)

Country Link
US (4) US9408886B2 (ko)
EP (1) EP2981279B1 (ko)
JP (1) JP6449849B2 (ko)
KR (1) KR102191695B1 (ko)
CN (1) CN105517562B (ko)
AU (1) AU2014247979B2 (ko)
BR (1) BR112015025398A2 (ko)
CA (1) CA2908832C (ko)
DK (1) DK2981279T3 (ko)
ES (1) ES2714863T3 (ko)
HK (1) HK1221159A1 (ko)
HU (1) HUE043971T2 (ko)
IL (1) IL241937B (ko)
MX (1) MX363077B (ko)
PL (1) PL2981279T3 (ko)
PT (1) PT2981279T (ko)
RU (1) RU2681213C2 (ko)
SG (2) SG10201708125PA (ko)
WO (1) WO2014165853A1 (ko)
ZA (1) ZA201508010B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2981279T3 (en) 2013-04-05 2019-03-25 Biomarck Pharmaceuticals Ltd MARCKS INHIBITOR PERIODS FOR INHIBITING METASTASES
CN108686220A (zh) * 2018-07-13 2018-10-23 刘慧荣 一种针对甲状腺癌的抗肿瘤剂

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544772B2 (en) 2001-06-26 2009-06-09 Biomarck Pharmaceuticals, Ltd. Methods for regulating inflammatory mediators and peptides useful therein
US8501911B2 (en) 1999-02-24 2013-08-06 Biomarck Pharmaceuticals, Ltd Methods of reducing inflammation and mucus hypersecretion
US7265088B1 (en) 2000-02-24 2007-09-04 North Carolina State University Method and compositions for altering mucus secretion
PT1411967E (pt) 2001-06-26 2011-09-30 Univ North Carolina State Péptido bloqueador que atua sobre a secreção de células inflamatórias
JP2005523879A (ja) 2001-10-05 2005-08-11 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア Sirs/sepsisを治療及び予防するための組成物及び方法
EP1355447B1 (en) 2002-04-17 2006-09-13 Canon Kabushiki Kaisha Public key certification providing apparatus
NZ560412A (en) 2005-01-20 2009-06-26 Biomarck Pharmaceuticals Ltd Mucin hypersecretion inhibitors based on the structure of MANS and methods of use
WO2006086681A2 (en) 2005-02-09 2006-08-17 Beth Israel Deaconess Medical Center, Inc. Methods of inhibiting smooth muscle cell migration and proliferation
ES2725599T3 (es) 2006-07-26 2019-09-25 Biomarck Pharmaceuticals Ltd Métodos para atenuar la liberación de mediadores inflamatorios y péptidos útiles en los mismos
CA2664844A1 (en) * 2006-10-06 2008-10-23 Celtaxsys, Inc. Chemorepulsion of cells
JP2010508512A (ja) 2006-10-27 2010-03-18 ジョージ メイソン インテレクチュアル プロパティーズ,インコーポレイテッド オブ フェアファックス,バージニア 転移性結腸直腸癌のアッセイ
WO2009062128A2 (en) 2007-11-08 2009-05-14 Indiana University Research And Technology Corporation Combination drug therapy for the treatment of cancer
EP2105511A1 (en) * 2008-03-28 2009-09-30 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. Medicament compositions and substances for treatment and identifying adenocarcinoma of the lung
WO2011079015A1 (en) * 2009-12-21 2011-06-30 The Regents Of The University Of California Rgd-containing cyclic peptides
JP6225104B2 (ja) * 2011-04-08 2017-11-01 タフツ メディカル センター インコーポレイテッドTufts Medical Center,Inc. ペプデューシンの設計および使用
DK2981279T3 (en) 2013-04-05 2019-03-25 Biomarck Pharmaceuticals Ltd MARCKS INHIBITOR PERIODS FOR INHIBITING METASTASES

Also Published As

Publication number Publication date
HK1221159A1 (zh) 2017-05-26
US20190119320A1 (en) 2019-04-25
RU2681213C2 (ru) 2019-03-05
US20170121369A1 (en) 2017-05-04
HUE043971T2 (hu) 2019-09-30
SG11201508249WA (en) 2015-11-27
JP2016516756A (ja) 2016-06-09
EP2981279A4 (en) 2016-11-09
CN105517562B (zh) 2018-12-28
KR102191695B1 (ko) 2020-12-16
CA2908832A1 (en) 2014-10-09
ES2714863T3 (es) 2019-05-30
EP2981279B1 (en) 2018-12-19
NZ712955A (en) 2021-03-26
US10683328B2 (en) 2020-06-16
WO2014165853A1 (en) 2014-10-09
KR20150140736A (ko) 2015-12-16
DK2981279T3 (en) 2019-03-25
EP2981279A1 (en) 2016-02-10
US10011636B2 (en) 2018-07-03
MX363077B (es) 2019-03-07
RU2015146997A3 (ko) 2018-03-13
BR112015025398A2 (pt) 2017-10-10
US11466054B2 (en) 2022-10-11
US20140302057A1 (en) 2014-10-09
CN105517562A (zh) 2016-04-20
PT2981279T (pt) 2019-03-14
US9408886B2 (en) 2016-08-09
JP6449849B2 (ja) 2019-01-09
RU2015146997A (ru) 2017-05-15
US20210130403A1 (en) 2021-05-06
CA2908832C (en) 2023-01-24
MX2015014036A (es) 2016-02-25
PL2981279T3 (pl) 2019-09-30
IL241937B (en) 2019-03-31
ZA201508010B (en) 2017-01-25
AU2014247979A1 (en) 2015-10-29
AU2014247979B2 (en) 2018-06-28

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