SG10201603027QA - Antimicrobial compounds and methods of making and using the same - Google Patents

Antimicrobial compounds and methods of making and using the same

Info

Publication number
SG10201603027QA
SG10201603027QA SG10201603027QA SG10201603027QA SG10201603027QA SG 10201603027Q A SG10201603027Q A SG 10201603027QA SG 10201603027Q A SG10201603027Q A SG 10201603027QA SG 10201603027Q A SG10201603027Q A SG 10201603027QA SG 10201603027Q A SG10201603027Q A SG 10201603027QA
Authority
SG
Singapore
Prior art keywords
making
methods
same
antimicrobial compounds
antimicrobial
Prior art date
Application number
SG10201603027QA
Other languages
English (en)
Inventor
Erin M Duffy
Ashoke Bhattacharjee
Shili Chen
Zoltan F Kanyo
Matthew Scheideman
Yuanqing Tang
Original Assignee
Melinta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Publication of SG10201603027QA publication Critical patent/SG10201603027QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/34One oxygen atom
    • C07D239/36One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
SG10201603027QA 2011-04-15 2012-04-11 Antimicrobial compounds and methods of making and using the same SG10201603027QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161476138P 2011-04-15 2011-04-15
US201161535118P 2011-09-15 2011-09-15
US201261610363P 2012-03-13 2012-03-13

Publications (1)

Publication Number Publication Date
SG10201603027QA true SG10201603027QA (en) 2016-05-30

Family

ID=47357660

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2013076575A SG194489A1 (en) 2011-04-15 2012-04-11 Antimicrobial compounds and methods of making and using the same
SG10201603027QA SG10201603027QA (en) 2011-04-15 2012-04-11 Antimicrobial compounds and methods of making and using the same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2013076575A SG194489A1 (en) 2011-04-15 2012-04-11 Antimicrobial compounds and methods of making and using the same

Country Status (20)

Country Link
US (2) US9221827B2 (fr)
EP (2) EP3404028A1 (fr)
JP (2) JP6317669B2 (fr)
KR (1) KR20140065378A (fr)
CN (2) CN103958514B (fr)
AR (1) AR088781A1 (fr)
AU (3) AU2012271228B2 (fr)
BR (1) BR112013026410A2 (fr)
CA (1) CA2833169A1 (fr)
DK (1) DK2697229T3 (fr)
EA (1) EA201391536A1 (fr)
ES (1) ES2665988T3 (fr)
HU (1) HUE036755T2 (fr)
IL (1) IL228845A0 (fr)
MX (1) MX357903B (fr)
MY (1) MY173518A (fr)
PT (1) PT2697229T (fr)
SG (2) SG194489A1 (fr)
TW (2) TW201843154A (fr)
WO (1) WO2012173689A2 (fr)

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DK2488532T3 (en) 2009-10-16 2018-08-13 Melinta Therapeutics Inc ANTIMICROBIAL COMPOUNDS AND PROCEDURES FOR PREPARING AND USING THE SAME
DK2488525T3 (en) 2009-10-16 2018-08-06 Melinta Therapeutics Inc ANTIMICROBIAL COMPOUNDS AND PROCEDURES FOR PREPARING AND USING THEREOF
PT2697229T (pt) 2011-04-15 2018-04-13 Melinta Therapeutics Inc Compostos antimicrobianos e seus métodos de fabrico e de utilização
JP2016519078A (ja) 2013-03-15 2016-06-30 エピザイム,インコーポレイティド Carm1阻害剤およびその使用
US9346802B2 (en) 2013-03-15 2016-05-24 Epizyme, Inc. CARM1 inhibitors and uses thereof
EP2970266B1 (fr) 2013-03-15 2018-01-31 Epizyme, Inc. Dérivés de 1-phénoxy-3-(alkylamino)-propan-2-ol en tant qu'inhibiteurs de carm1 et leurs utilisations
KR20160070066A (ko) 2013-09-09 2016-06-17 멜린타 테라퓨틱스, 인크. 항균 화합물, 및 이의 제조 방법 및 이용 방법
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WO2016094307A1 (fr) 2014-12-08 2016-06-16 The Research Foundation For The State University Of New York Anti-fongiques ciblant la synthèse de shingolipides fongiques
MX2017011616A (es) * 2015-03-11 2018-04-11 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos para hacerlos y usarlos.
CN105669519B (zh) * 2016-01-04 2018-01-05 北方民族大学 吲哚类化合物、制备方法及其作为抗耐药菌药物的应用
WO2017193023A1 (fr) * 2016-05-06 2017-11-09 Melinta Therapeutics, Inc. Antimicrobiens et leurs procédés de préparation et d'utilisation
EP3452478A1 (fr) 2016-05-06 2019-03-13 Melinta Therapeutics, Inc. Antimicrobiens et leurs procédés de préparation et d'utilisation
JP2019515041A (ja) 2016-05-06 2019-06-06 メリンタ セラピューティクス、 インコーポレイテッドMelinta Therapeutics, Inc. 抗菌剤ならびにそれを作製および使用する方法
EP3638649A4 (fr) 2017-06-16 2021-03-17 The Research Foundation for The State University of New York Composés anti-fongiques ciblant la synthèse de shingolipides fongiques
EP3642205A1 (fr) 2017-06-19 2020-04-29 Erin M. Duffy Agents antimicrobiens et leurs procédés de préparation et d'utilisation
US20210403473A1 (en) * 2018-02-21 2021-12-30 BioVersys AG Antimicrobial compounds and methods of making and using the same
US20210253589A1 (en) 2018-06-06 2021-08-19 BioVersys AG Aminomethylamidine and methylamidine antimicrobial compounds
WO2019234508A1 (fr) 2018-06-06 2019-12-12 BioVersys AG Agents de biodéfense
WO2020115547A2 (fr) * 2018-12-07 2020-06-11 BioVersys AG Composés pyrrolo[2,3-d]pyrimidin-2-one antimicrobiens
EP4058146A1 (fr) * 2019-11-13 2022-09-21 Curza Global LLC Composés antimicrobiens et procédés
CN111254091B (zh) * 2020-01-20 2022-04-19 浙江工业大学 一种嗜麦芽窄食单胞菌gyh及其在降解氯代烃类污染物中的应用

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DK2488525T3 (en) * 2009-10-16 2018-08-06 Melinta Therapeutics Inc ANTIMICROBIAL COMPOUNDS AND PROCEDURES FOR PREPARING AND USING THEREOF
PT2697229T (pt) 2011-04-15 2018-04-13 Melinta Therapeutics Inc Compostos antimicrobianos e seus métodos de fabrico e de utilização

Also Published As

Publication number Publication date
US20140163049A1 (en) 2014-06-12
AR088781A1 (es) 2014-07-10
JP6317669B2 (ja) 2018-04-25
MY173518A (en) 2020-01-30
WO2012173689A3 (fr) 2013-04-04
EP2697229A2 (fr) 2014-02-19
KR20140065378A (ko) 2014-05-29
TW201305172A (zh) 2013-02-01
WO2012173689A2 (fr) 2012-12-20
US9221827B2 (en) 2015-12-29
BR112013026410A2 (pt) 2017-06-27
AU2019204745A1 (en) 2019-07-18
US20190322668A1 (en) 2019-10-24
HUE036755T2 (hu) 2018-07-30
MX2013012015A (es) 2014-10-24
CN103958514A (zh) 2014-07-30
TWI656123B (zh) 2019-04-11
CN109053695A (zh) 2018-12-21
EP3404028A1 (fr) 2018-11-21
DK2697229T3 (en) 2018-04-23
EP2697229B1 (fr) 2018-04-04
PT2697229T (pt) 2018-04-13
IL228845A0 (en) 2013-12-31
ES2665988T3 (es) 2018-04-30
JP2018115206A (ja) 2018-07-26
AU2012271228B2 (en) 2017-04-13
EA201391536A1 (ru) 2014-08-29
EP2697229A4 (fr) 2014-09-10
JP2014510788A (ja) 2014-05-01
AU2012271228A1 (en) 2013-11-14
SG194489A1 (en) 2013-12-30
CA2833169A1 (fr) 2012-12-20
MX357903B (es) 2018-07-30
TW201843154A (zh) 2018-12-16
CN103958514B (zh) 2018-07-03
AU2017204803A1 (en) 2017-07-27

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