SE8901224L - THE PRODUCTS - Google Patents

THE PRODUCTS

Info

Publication number
SE8901224L
SE8901224L SE8901224A SE8901224A SE8901224L SE 8901224 L SE8901224 L SE 8901224L SE 8901224 A SE8901224 A SE 8901224A SE 8901224 A SE8901224 A SE 8901224A SE 8901224 L SE8901224 L SE 8901224L
Authority
SE
Sweden
Prior art keywords
processes
image
products
quaternaryammonio
iminoacetamido
Prior art date
Application number
SE8901224A
Other languages
Swedish (sv)
Other versions
SE8901224D0 (en
SE470259B (en
Inventor
M Oka
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8901224D0 publication Critical patent/SE8901224D0/en
Publication of SE8901224L publication Critical patent/SE8901224L/en
Publication of SE470259B publication Critical patent/SE470259B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(substituted)-iminoacetamido]-3 -[3-(quaternaryammonio)-1 - propen-1-yl]-3-cephem-4-carboxylates of the formula <IMAGE> in which R<1> and R<2> are as defined herein and <IMAGE> is a quaternary ammonio group as defined herein, and salts, solvates, hydrates and esters thereof, are potent antibacterial agents. Processes for their preparation and intermediates in such processes are described.
SE8901224A 1984-04-09 1989-04-06 Intermediates for cephalosporins SE470259B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59794184A 1984-04-09 1984-04-09

Publications (3)

Publication Number Publication Date
SE8901224D0 SE8901224D0 (en) 1989-04-06
SE8901224L true SE8901224L (en) 1989-04-06
SE470259B SE470259B (en) 1993-12-20

Family

ID=24393575

Family Applications (4)

Application Number Title Priority Date Filing Date
SE8501680A SE466205B (en) 1984-04-09 1985-04-03 7- / 2- (5-AMINO-1,2,4-THIADIAZOL-3-YL) -2- (SUBSTITUTED) IMINOACETAMIDE / -3- / 3- (QUATERNARY AMMONIO) -1-PROPEN-1-YL / - 3-cephem-4-carboxylates
SE8901226A SE470260B (en) 1984-04-09 1989-04-06 Intermediates for cepholosporins
SE8901225A SE505256C2 (en) 1984-04-09 1989-04-06 New 7-amino cephalosporin derivatives with a quaternary ammonio group and process for the preparation thereof
SE8901224A SE470259B (en) 1984-04-09 1989-04-06 Intermediates for cephalosporins

Family Applications Before (3)

Application Number Title Priority Date Filing Date
SE8501680A SE466205B (en) 1984-04-09 1985-04-03 7- / 2- (5-AMINO-1,2,4-THIADIAZOL-3-YL) -2- (SUBSTITUTED) IMINOACETAMIDE / -3- / 3- (QUATERNARY AMMONIO) -1-PROPEN-1-YL / - 3-cephem-4-carboxylates
SE8901226A SE470260B (en) 1984-04-09 1989-04-06 Intermediates for cepholosporins
SE8901225A SE505256C2 (en) 1984-04-09 1989-04-06 New 7-amino cephalosporin derivatives with a quaternary ammonio group and process for the preparation thereof

Country Status (31)

Country Link
JP (4) JPS615084A (en)
KR (1) KR870002166B1 (en)
AR (1) AR244694A1 (en)
AT (1) AT388735B (en)
AU (2) AU580990B2 (en)
BE (1) BE902148A (en)
CA (3) CA1276929C (en)
CH (1) CH669197A5 (en)
DD (3) DD249024A5 (en)
DE (1) DE3512225A1 (en)
DK (1) DK155985A (en)
ES (4) ES8607318A1 (en)
FI (1) FI84830C (en)
FR (1) FR2563832B1 (en)
GB (3) GB2157293B (en)
GR (1) GR850883B (en)
HU (2) HU193750B (en)
IE (2) IE58408B1 (en)
IL (1) IL74826A (en)
IT (1) IT1190353B (en)
LU (1) LU85840A1 (en)
MY (1) MY101940A (en)
NL (1) NL192925C (en)
NZ (1) NZ211659A (en)
OA (1) OA07985A (en)
PT (1) PT80246B (en)
RU (1) RU2056425C1 (en)
SE (4) SE466205B (en)
SU (4) SU1375140A3 (en)
YU (2) YU46151B (en)
ZA (1) ZA852236B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61145186A (en) * 1984-12-20 1986-07-02 Meiji Seika Kaisha Ltd Novel cephem compound and preparation thereof
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
DE3650157T2 (en) * 1985-12-26 1995-05-04 Eisai Co Ltd CEPHALOSPORINE COMPOUNDS.
AU614723B2 (en) * 1986-10-13 1991-09-12 Eisai Co. Ltd. 3-propenylcephem derivative
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
JPH085897B2 (en) * 1986-11-06 1996-01-24 エーザイ株式会社 3-propenyl cephem derivative
FR2622585B1 (en) * 1987-11-03 1991-04-19 Roussel Uclaf NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A SUBSTITUTED VINYL RADICAL, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED
JPH0699449B2 (en) * 1988-03-16 1994-12-07 エーザイ株式会社 Synthetic intermediate of cephem derivative
EP0612751A3 (en) * 1988-03-16 1994-09-21 Eisai Co Ltd Compounds for the preparation of cephem derivatives.
FR2655042B1 (en) * 1989-11-29 1994-01-21 Adir Cie NOVEL SUBSTITUTED BENZOTHIAZOLINONES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2663332B1 (en) * 1990-06-15 1997-11-07 Roussel Uclaf NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A RADICAL PROPENYL SUBSTITUTED BY A QUATERNARY AMMONIUM, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED.
US5126336A (en) * 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
AT396108B (en) * 1991-08-21 1993-06-25 Biochemie Gmbh NEW PROCESS AND NEW INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF 7-AMINOCEPHALOSPORANIC ACID DERIVATIVES
JPH0741484A (en) * 1993-07-29 1995-02-10 Katayama Seiyakushiyo:Kk Cephem compound and antimicrobial agent
US5661144A (en) * 1994-08-16 1997-08-26 Meiji Seika Kabushiki Kaisha Cephem derivatives with 3-substituted bis heterocycles
PL345266A1 (en) 1998-06-22 2001-12-03 Hoffmann La Roche Propenyl cephalosporin derivatives
EP1666483B1 (en) 2003-09-09 2011-08-17 Nippon Chemical Industrial Company Limited Process for producing 3-chloromethyl-3-cephem derivative

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US4390534A (en) * 1978-12-29 1983-06-28 Fujisawa Pharmaceutical Co., Ltd. Cephem and cepham compounds
EP0025017A1 (en) * 1979-08-28 1981-03-11 Ciba-Geigy Ag Polyazathia compounds, process for their preparation, pharmaceutical preparations containing such compounds and use of the latter
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
GR75644B (en) * 1980-06-18 1984-08-02 Fujisawa Pharmaceutical Co
GR78245B (en) * 1980-09-12 1984-09-26 Ciba Geigy Ag
US4521413A (en) * 1981-09-14 1985-06-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives

Also Published As

Publication number Publication date
SE470260B (en) 1993-12-20
FI84830C (en) 1992-01-27
GB8721347D0 (en) 1987-10-14
SE8901225D0 (en) 1989-04-06
BE902148A (en) 1985-10-09
IE58403B1 (en) 1993-09-22
ZA852236B (en) 1985-11-27
IT1190353B (en) 1988-02-16
DE3512225A1 (en) 1985-10-17
NL192925B (en) 1998-01-05
YU118987A (en) 1988-10-31
PT80246A (en) 1985-05-01
SE8501680D0 (en) 1985-04-03
YU46213B (en) 1993-05-28
NL192925C (en) 1998-05-07
DD249024A5 (en) 1987-08-26
RU2056425C1 (en) 1996-03-20
JPH0350754B2 (en) 1991-08-02
HU193750B (en) 1987-11-30
NZ211659A (en) 1988-11-29
ES542013A0 (en) 1986-06-16
DD251752A5 (en) 1987-11-25
ES8800949A1 (en) 1987-12-01
KR870002166B1 (en) 1987-12-14
SE8901224D0 (en) 1989-04-06
SE8901226L (en) 1989-04-06
SE8501680L (en) 1985-10-10
LU85840A1 (en) 1985-12-16
ES551550A0 (en) 1987-06-01
GB2194789B (en) 1988-10-12
KR850007424A (en) 1985-12-04
JPH0351716B2 (en) 1991-08-07
FI84830B (en) 1991-10-15
AU580990B2 (en) 1989-02-09
DD236735A5 (en) 1986-06-18
GB2157293B (en) 1988-10-05
SE470259B (en) 1993-12-20
JPH0262557B2 (en) 1990-12-26
AR244694A1 (en) 1993-11-30
IE58408B1 (en) 1993-09-22
OA07985A (en) 1987-01-31
ES557060A0 (en) 1987-12-01
GR850883B (en) 1985-11-25
ES8607318A1 (en) 1986-06-16
NL8501002A (en) 1985-11-01
FR2563832B1 (en) 1989-08-18
MY101940A (en) 1992-02-15
GB8721346D0 (en) 1987-10-14
PT80246B (en) 1987-10-20
JPS615084A (en) 1986-01-10
SU1436882A3 (en) 1988-11-07
GB8508846D0 (en) 1985-05-09
IE850866L (en) 1985-10-09
ES551551A0 (en) 1987-07-01
FI851379L (en) 1985-10-10
GB2194790A (en) 1988-03-16
SE505256C2 (en) 1997-07-21
GB2194790B (en) 1988-10-05
YU46151B (en) 1993-05-28
IT8520267A0 (en) 1985-04-05
HU204277B (en) 1991-12-30
AU610278B2 (en) 1991-05-16
IL74826A0 (en) 1985-07-31
CH669197A5 (en) 1989-02-28
IL74826A (en) 1990-01-18
SU1367858A3 (en) 1988-01-15
AU2504188A (en) 1989-03-02
GB2194789A (en) 1988-03-16
GB2157293A (en) 1985-10-23
SE8901225L (en) 1989-04-06
SE466205B (en) 1992-01-13
SE8901226D0 (en) 1989-04-06
FI851379A0 (en) 1985-04-04
JPH0357106B2 (en) 1991-08-30
FR2563832A1 (en) 1985-11-08
AT388735B (en) 1989-08-25
JPS61143390A (en) 1986-07-01
CA1276929C (en) 1990-11-27
HUT37622A (en) 1986-01-23
CA1340638C (en) 1999-07-06
SU1375140A3 (en) 1988-02-15
YU60085A (en) 1987-12-31
JPS61143387A (en) 1986-07-01
DE3512225C2 (en) 1990-02-22
ATA103985A (en) 1989-01-15
ES8706694A1 (en) 1987-07-01
CA1340672C (en) 1999-07-20
JPS61143391A (en) 1986-07-01
SU1487814A3 (en) 1989-06-15
AU4086285A (en) 1985-10-17
DK155985A (en) 1985-10-10
ES8706155A1 (en) 1987-06-01
DK155985D0 (en) 1985-04-03

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