BE902148A - CEPHEMES. - Google Patents

CEPHEMES.

Info

Publication number
BE902148A
BE902148A BE0/214810A BE214810A BE902148A BE 902148 A BE902148 A BE 902148A BE 0/214810 A BE0/214810 A BE 0/214810A BE 214810 A BE214810 A BE 214810A BE 902148 A BE902148 A BE 902148A
Authority
BE
Belgium
Prior art keywords
quaternary ammonio
cephemes
iminoacetamido
cephem
propen
Prior art date
Application number
BE0/214810A
Other languages
French (fr)
Inventor
H Yamashita
M Oka
T Naito
J Okumura
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE902148A publication Critical patent/BE902148A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

7-( 2-(5-Amino-1,2,4- thiadiazol-3-yl)-2-iminoacétamido (substitué) )-3-(3- (ammonio quaternaire)-1-propén-1-yl)-3-céphème-4-carboxylates de formule (I) ou R1 et R2 représentent des radicaux définis et -N==Q représente un radical ammonio quaternaire défini, outre leurs sels, solvates, hydrates et esters qui sont de puissants agents antibactériens. L'invention concerne aussi des procédés pour préparer ces composés et différents intremédiaires.7- (2- (5-Amino-1,2,4- thiadiazol-3-yl) -2-iminoacetamido (substituted)) -3- (3- (quaternary ammonio) -1-propen-1-yl) - 3-cephem-4-carboxylates of formula (I) where R1 and R2 represent defined radicals and -N == Q represents a defined quaternary ammonio radical, in addition to their salts, solvates, hydrates and esters which are powerful antibacterial agents. The invention also relates to methods for preparing these compounds and various intermediates.

BE0/214810A 1984-04-09 1985-04-09 CEPHEMES. BE902148A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59794184A 1984-04-09 1984-04-09

Publications (1)

Publication Number Publication Date
BE902148A true BE902148A (en) 1985-10-09

Family

ID=24393575

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214810A BE902148A (en) 1984-04-09 1985-04-09 CEPHEMES.

Country Status (31)

Country Link
JP (4) JPS615084A (en)
KR (1) KR870002166B1 (en)
AR (1) AR244694A1 (en)
AT (1) AT388735B (en)
AU (2) AU580990B2 (en)
BE (1) BE902148A (en)
CA (3) CA1276929C (en)
CH (1) CH669197A5 (en)
DD (3) DD249024A5 (en)
DE (1) DE3512225A1 (en)
DK (1) DK155985A (en)
ES (4) ES8607318A1 (en)
FI (1) FI84830C (en)
FR (1) FR2563832B1 (en)
GB (3) GB2157293B (en)
GR (1) GR850883B (en)
HU (2) HU193750B (en)
IE (2) IE58408B1 (en)
IL (1) IL74826A (en)
IT (1) IT1190353B (en)
LU (1) LU85840A1 (en)
MY (1) MY101940A (en)
NL (1) NL192925C (en)
NZ (1) NZ211659A (en)
OA (1) OA07985A (en)
PT (1) PT80246B (en)
RU (1) RU2056425C1 (en)
SE (4) SE466205B (en)
SU (4) SU1436882A3 (en)
YU (2) YU46151B (en)
ZA (1) ZA852236B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61145186A (en) * 1984-12-20 1986-07-02 Meiji Seika Kaisha Ltd Novel cephem compound and preparation thereof
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
ATE114657T1 (en) * 1985-12-26 1994-12-15 Eisai Co Ltd CEPHALOSPORIN COMPOUNDS.
AU614723B2 (en) * 1986-10-13 1991-09-12 Eisai Co. Ltd. 3-propenylcephem derivative
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
JPH085897B2 (en) * 1986-11-06 1996-01-24 エーザイ株式会社 3-propenyl cephem derivative
FR2622585B1 (en) * 1987-11-03 1991-04-19 Roussel Uclaf NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A SUBSTITUTED VINYL RADICAL, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED
JPH0699449B2 (en) * 1988-03-16 1994-12-07 エーザイ株式会社 Synthetic intermediate of cephem derivative
ATE212027T1 (en) * 1988-03-16 2002-02-15 Eisai Co Ltd CEPHEM DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
FR2655042B1 (en) * 1989-11-29 1994-01-21 Adir Cie NOVEL SUBSTITUTED BENZOTHIAZOLINONES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2663332B1 (en) * 1990-06-15 1997-11-07 Roussel Uclaf NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A RADICAL PROPENYL SUBSTITUTED BY A QUATERNARY AMMONIUM, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED.
US5126336A (en) * 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
AT396108B (en) * 1991-08-21 1993-06-25 Biochemie Gmbh NEW PROCESS AND NEW INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF 7-AMINOCEPHALOSPORANIC ACID DERIVATIVES
JPH0741484A (en) * 1993-07-29 1995-02-10 Katayama Seiyakushiyo:Kk Cephem compound and antimicrobial agent
EP0723966A4 (en) * 1994-08-16 1997-01-29 Meiji Seika Co Novel cephem derivative
TR200003807T2 (en) 1998-06-22 2001-06-21 Basilea Pharmaceutica Ag Propenyl cephalosporin derivatives
WO2005026176A1 (en) 2003-09-09 2005-03-24 Nippon Chemical Industrial Co.,Ltd. Process for producing 3-chloromethyl-3-cephem derivative

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US4390534A (en) * 1978-12-29 1983-06-28 Fujisawa Pharmaceutical Co., Ltd. Cephem and cepham compounds
EP0025017A1 (en) * 1979-08-28 1981-03-11 Ciba-Geigy Ag Polyazathia compounds, process for their preparation, pharmaceutical preparations containing such compounds and use of the latter
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
GR75644B (en) * 1980-06-18 1984-08-02 Fujisawa Pharmaceutical Co
GR78245B (en) * 1980-09-12 1984-09-26 Ciba Geigy Ag
US4521413A (en) * 1981-09-14 1985-06-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives

Also Published As

Publication number Publication date
IL74826A (en) 1990-01-18
GB2157293B (en) 1988-10-05
ZA852236B (en) 1985-11-27
HU193750B (en) 1987-11-30
GB8508846D0 (en) 1985-05-09
FR2563832A1 (en) 1985-11-08
GB2194790B (en) 1988-10-05
ES551550A0 (en) 1987-06-01
JPH0350754B2 (en) 1991-08-02
AU580990B2 (en) 1989-02-09
GB2157293A (en) 1985-10-23
SU1436882A3 (en) 1988-11-07
JPH0351716B2 (en) 1991-08-07
RU2056425C1 (en) 1996-03-20
MY101940A (en) 1992-02-15
ES8800949A1 (en) 1987-12-01
AU610278B2 (en) 1991-05-16
GB2194790A (en) 1988-03-16
NL8501002A (en) 1985-11-01
GR850883B (en) 1985-11-25
HUT37622A (en) 1986-01-23
ES8706694A1 (en) 1987-07-01
SU1367858A3 (en) 1988-01-15
YU46151B (en) 1993-05-28
DD251752A5 (en) 1987-11-25
SE8901224L (en) 1989-04-06
CA1276929C (en) 1990-11-27
SE8501680L (en) 1985-10-10
IE58408B1 (en) 1993-09-22
CH669197A5 (en) 1989-02-28
SE8501680D0 (en) 1985-04-03
FI84830B (en) 1991-10-15
IL74826A0 (en) 1985-07-31
ATA103985A (en) 1989-01-15
SE505256C2 (en) 1997-07-21
ES557060A0 (en) 1987-12-01
PT80246B (en) 1987-10-20
HU204277B (en) 1991-12-30
PT80246A (en) 1985-05-01
JPH0357106B2 (en) 1991-08-30
SU1375140A3 (en) 1988-02-15
ES551551A0 (en) 1987-07-01
DE3512225C2 (en) 1990-02-22
GB2194789A (en) 1988-03-16
FI851379L (en) 1985-10-10
JPS61143390A (en) 1986-07-01
JPS61143387A (en) 1986-07-01
OA07985A (en) 1987-01-31
SE8901225D0 (en) 1989-04-06
CA1340638C (en) 1999-07-06
GB8721347D0 (en) 1987-10-14
YU46213B (en) 1993-05-28
IT8520267A0 (en) 1985-04-05
JPS615084A (en) 1986-01-10
ES8607318A1 (en) 1986-06-16
JPH0262557B2 (en) 1990-12-26
KR870002166B1 (en) 1987-12-14
SE466205B (en) 1992-01-13
LU85840A1 (en) 1985-12-16
FI851379A0 (en) 1985-04-04
CA1340672C (en) 1999-07-20
NL192925B (en) 1998-01-05
FR2563832B1 (en) 1989-08-18
ES8706155A1 (en) 1987-06-01
KR850007424A (en) 1985-12-04
IE58403B1 (en) 1993-09-22
GB8721346D0 (en) 1987-10-14
AT388735B (en) 1989-08-25
NZ211659A (en) 1988-11-29
YU118987A (en) 1988-10-31
SE8901225L (en) 1989-04-06
SE8901226L (en) 1989-04-06
AR244694A1 (en) 1993-11-30
JPS61143391A (en) 1986-07-01
SE8901224D0 (en) 1989-04-06
NL192925C (en) 1998-05-07
SE470259B (en) 1993-12-20
DK155985D0 (en) 1985-04-03
DK155985A (en) 1985-10-10
ES542013A0 (en) 1986-06-16
YU60085A (en) 1987-12-31
DD249024A5 (en) 1987-08-26
DD236735A5 (en) 1986-06-18
FI84830C (en) 1992-01-27
IE850866L (en) 1985-10-09
GB2194789B (en) 1988-10-12
DE3512225A1 (en) 1985-10-17
AU4086285A (en) 1985-10-17
IT1190353B (en) 1988-02-16
SE470260B (en) 1993-12-20
SU1487814A3 (en) 1989-06-15
SE8901226D0 (en) 1989-04-06
AU2504188A (en) 1989-03-02

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *BRISTOL-MYERS CY

Effective date: 20050409

RE20 Patent expired

Owner name: *BRISTOL-MYERS CY

Effective date: 20050409