SE8800651L - PIPERAZINE DERIVATIVES AND PROCEDURES FOR PREPARING THESE - Google Patents

PIPERAZINE DERIVATIVES AND PROCEDURES FOR PREPARING THESE

Info

Publication number
SE8800651L
SE8800651L SE8800651A SE8800651A SE8800651L SE 8800651 L SE8800651 L SE 8800651L SE 8800651 A SE8800651 A SE 8800651A SE 8800651 A SE8800651 A SE 8800651A SE 8800651 L SE8800651 L SE 8800651L
Authority
SE
Sweden
Prior art keywords
formula
compound
preparation
piperazine derivatives
procedures
Prior art date
Application number
SE8800651A
Other languages
Swedish (sv)
Other versions
SE8800651D0 (en
Inventor
Z Budai
L Gregor
T Mezei
K Reiter
E J Tajthy
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU71887A external-priority patent/HU198477B/en
Priority claimed from HU71687A external-priority patent/HU197313B/en
Priority claimed from HU71787A external-priority patent/HU198204B/en
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of SE8800651D0 publication Critical patent/SE8800651D0/en
Publication of SE8800651L publication Critical patent/SE8800651L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF A b s t r a c t the invention relates to a new and improved process for the preparation of 8-{4- ¢ 4-(2-pyrimidinyl)- -l-piperazinyl!-butyl}-8-aza-spiro¢ 4.5!decane-7,9- -dione of the Formula I <IMG> (I) and pharmaceutically acceptable acid addition salts thereof, which comprises hydrogenating a compound of the general Formula II <IMG> (II) (wherein A stands for -C?C- or -CH=CH-) and, if desired, converting the compound of the Formula I thus obtained into a pharmaceutically acceptable acid addition salt thereof. The compound of the Formula I is a known anxioselective agent. The invention also relates to intermediates used in the above process and a method for the preparation thereof.
SE8800651A 1987-02-25 1988-02-25 PIPERAZINE DERIVATIVES AND PROCEDURES FOR PREPARING THESE SE8800651L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU71887A HU198477B (en) 1987-02-25 1987-02-25 Process for producing pyrimidinyl piperazine derivatives
HU71687A HU197313B (en) 1987-02-25 1987-02-25 Process for producing 8-azaspiro <4.5> decane-7,9-dione-8-propine-/2/
HU71787A HU198204B (en) 1987-02-25 1987-02-25 Process for production of derivatives of piperasine

Publications (2)

Publication Number Publication Date
SE8800651D0 SE8800651D0 (en) 1988-02-25
SE8800651L true SE8800651L (en) 1988-08-26

Family

ID=27269942

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8800651A SE8800651L (en) 1987-02-25 1988-02-25 PIPERAZINE DERIVATIVES AND PROCEDURES FOR PREPARING THESE

Country Status (20)

Country Link
KR (1) KR880009955A (en)
CN (1) CN88100923A (en)
AT (1) AT395851B (en)
BE (1) BE1001464A3 (en)
CA (1) CA1300141C (en)
CH (1) CH677924A5 (en)
CS (1) CS274423B2 (en)
DE (1) DE3806009C2 (en)
DK (1) DK99388A (en)
ES (1) ES2009236A6 (en)
FI (1) FI880895A (en)
FR (1) FR2615853B1 (en)
GB (1) GB2201417B (en)
GR (1) GR1002245B (en)
IL (1) IL85545A (en)
IT (1) IT1217342B (en)
NL (1) NL8800484A (en)
PL (1) PL152958B1 (en)
SE (1) SE8800651L (en)
YU (1) YU46441B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU217129B (en) * 1993-07-16 1999-11-29 EGIS Gyógyszergyár Rt. Process for the preparation of buspiron as therapeutical active ingredient of high purity
KR950014099A (en) * 1993-11-10 1995-06-15 장기하 Method for preparing N- (2-pyrimidyl) piperazinyl butylamide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545543B1 (en) * 1964-07-03 1970-01-22 Astra Apotekarnes Kem Fab 4-aminobutinylimides, their salts and processes for their preparation
SE300422B (en) * 1964-07-03 1968-04-29 Astra Ab
US3354178A (en) * 1965-04-09 1967-11-21 Sterling Drug Inc Nu-(4-amino-2-butynyl)-nu-alkylcarboxamides
BE759371A (en) * 1969-11-24 1971-05-24 Bristol Myers Co HETEROCYCLICAL AZASPIRODECANEDIONES AND METHODS FOR THEIR PREPARATION
JPS6310786A (en) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd Novel imide derivative and production thereof
JPS6310760A (en) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd Novel production of imide derivative

Also Published As

Publication number Publication date
ES2009236A6 (en) 1989-09-16
PL152958B1 (en) 1991-02-28
GR1002245B (en) 1996-04-22
AT395851B (en) 1993-03-25
YU46441B (en) 1993-10-20
GB2201417B (en) 1990-10-31
DK99388A (en) 1988-08-26
SE8800651D0 (en) 1988-02-25
CH677924A5 (en) 1991-07-15
BE1001464A3 (en) 1989-11-07
GB8804385D0 (en) 1988-03-23
GB2201417A (en) 1988-09-01
FR2615853A1 (en) 1988-12-02
DE3806009A1 (en) 1988-09-08
PL270815A1 (en) 1989-04-03
NL8800484A (en) 1988-09-16
FI880895A (en) 1988-08-26
KR880009955A (en) 1988-10-06
YU36288A (en) 1989-10-31
ATA47688A (en) 1992-08-15
IT1217342B (en) 1990-03-22
DE3806009C2 (en) 1996-09-12
IL85545A (en) 1992-05-25
CS274423B2 (en) 1991-04-11
FI880895A0 (en) 1988-02-25
CN88100923A (en) 1988-09-28
GR880100108A (en) 1988-12-16
IL85545A0 (en) 1988-08-31
FR2615853B1 (en) 1991-01-04
DK99388D0 (en) 1988-02-25
CA1300141C (en) 1992-05-05
IT8819545A0 (en) 1988-02-25
CS122288A2 (en) 1990-08-14

Similar Documents

Publication Publication Date Title
CA1258859A (en) Carbostyril derivative and process for preparing same
ATE22889T1 (en) 8-CHLORINE-1,5-BENZOTHIAZEPINE DERIVATIVES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS.
EP0291799A3 (en) Dioxyalkylenearyl-dihydropyridines and their intermediary compounds, process for their preparation and their use
ES8306142A1 (en) Substituted N-(4-indolyl-piperidino-alkyl) benzimidazolones, processes for their preparation and their use as pharmaceutical preparations.
AU7215987A (en) 1,4-disubstituted piperazine derivatives, pharmaceutical compositions containing them and process for preparing same
EP0186023A3 (en) Biliary acid derivatives, process for their preparation and pharmaceutical compositions containing them
SE8800651L (en) PIPERAZINE DERIVATIVES AND PROCEDURES FOR PREPARING THESE
CS242088A2 (en) Method of 1-cyclopropyl-7-substituted-6-fluor-4-oxo-1,4-dihydroquinoline-3-carboxylic acid&#39;s derivatives production
US4085214A (en) Stable pro-drug forms of theophylline
ATE15370T1 (en) 3-PIPERIDINYL-INDOLES DERIVATIVES, THEIR SALTS, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICINAL PRODUCTS AND MEDICATIONS CONTAINING THEM.
TNSN87085A1 (en) DERIVATIVES OF 4- (AROYLAMINO) PIPERIDINEBUTANAMIDE, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS ANTIDIARRHOIC
AU1971688A (en) Benzimidazole derivatives, their preparation and their application in therapeutics
ES8304125A1 (en) Oxadiazolopyrimidine derivatives, process and intermediates for their production and pharmaceutical preparations containing such an oxadiazolopyrimidine derivative.
NO873097D0 (en) PREPARATION OF 1-METHYLAMINOKINOLINCARBOXYL ACID DERIVATIVES.
EP0065270A3 (en) Process for the preparation of 7-(2-amino-2-phenylacetamido)cephem derivatives and their use for the preparation of antibacterial agents
YU42057B (en) Process for preparing 1-furyl-3,4-dihyndro isoquinolines
ES8704463A1 (en) Substituted derivatives of 2-(N-alkenyl-N-phenyl-amino) imidazoline, their acid addition salts, medicaments containing them and process for their preparation.
ES2004255A6 (en) PHARMACOLOGICALLY ACTIVE OCTAHYDRO-PYRIDO(1,2-a) PYRAZINES.
IE790237L (en) Benzimidazol-2-ones.
ES8206435A1 (en) A new p-chlorophenoxyacetic acid derivative, its method of preparation and pharmaceutical composition.
PT99378A (en) PROCESS FOR THE PREPARATION OF UTERIC INTERMEDIARIES FOR THE PREPARATION OF 4,5-DIFLUOROANTRANILIC ACID
ES467635A1 (en) 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof
FI882667A (en) FOERFARANDE FOER FRAMSTAELLNING AV ANTIBAKTERISKA VID 7-STAELLNINGEN SUBSTITUERADE 1-CYCLOPROPYL-6-FLUOR -1,4-DIHYDRO-4-OXO-1,8-NAFTYRIDIN-3-CARBOXYLSYROR.

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8800651-5

Effective date: 19911118