SE8602854D0 - NEW SACCHARIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
NEW SACCHARIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- SE8602854D0 SE8602854D0 SE8602854A SE8602854A SE8602854D0 SE 8602854 D0 SE8602854 D0 SE 8602854D0 SE 8602854 A SE8602854 A SE 8602854A SE 8602854 A SE8602854 A SE 8602854A SE 8602854 D0 SE8602854 D0 SE 8602854D0
- Authority
- SE
- Sweden
- Prior art keywords
- hydroxytetradecanoyl
- hydrogen
- group
- represent
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
New saccharides having the formula (I), wherein R'1, R'2, R'3 and R'4 are different or identical and independently represent hydrogen or an optionally substituted acyl group and W, X, Y and Z are identical or different and independently represent oxygen or an imino group with the proviso that a) at least one of the substituents R'1, R'2, R'3 and R'4 represents an acyl group and b) when Z and X are an imino group, and W and Y are oxygen alpha ) R'1 and R'2 do not simultaneously represent (R)-3-hydroxytetradecanoyl, when R'3 and R'4 are identical and represent (R)-3-hydroxytetradecanoyl, or when R'4 is (R)-3-dodecanoyloxytetradecanoyl and R'3 represent tetradecanoyloxidtetradecanoyl, beta ) R'2 is not hydrogen or (R)-3-hydroxytetradecanoyl when R'1 and R'3 are hydrogen and R'4 is (R)-3-hydroxytetradecanoyl, and gamma ) R'1 and R'3 are not the group-(CO)2.CH2.(CHOH)4.CH2OH when the other substituents are hydrogen. Other new saccharides have the formula (III), wherein R''1 and R''2 are different or identical and are independently from each other hydrogen or an optionally substituted acyl group and a) Y is O and X is NH, but alpha when R''1 is (R)-3-hydroxytetradecanoyl, R''2 is not (R)-3-hydroxytetradecanoyl or (R)-3-hexadecanoyloxytetradecanoyl, beta R''1 is not hydrogen and gamma R''1 and R''2 are not the acetyl group or the group -CO.(CH2)10.CH3, b) Y is O and X is O and c) Y is NH and X is O. The invention also relates to the process for the production and utilization thereof as pharmaceutical agents.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT193685A ATA193685A (en) | 1985-06-28 | 1985-06-28 | METHOD FOR PRODUCING GLUCOSAMINE DERIVATIVES |
| AT193585A ATA193585A (en) | 1985-06-28 | 1985-06-28 | METHOD FOR PRODUCING NEW DISACCHARIDES |
| AT193785A ATA193785A (en) | 1985-06-28 | 1985-06-28 | METHOD FOR PRODUCING NEW GLUCOSE DERIVATIVES |
| AT193885A ATA193885A (en) | 1985-06-28 | 1985-06-28 | METHOD FOR PRODUCING NEW 3-AMINO-3-DESOXY-D-GLUCOSE DERIVATIVES |
| AT122286 | 1986-05-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8602854D0 true SE8602854D0 (en) | 1986-06-26 |
| SE8602854L SE8602854L (en) | 1986-12-29 |
Family
ID=27506246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8602854A SE8602854L (en) | 1985-06-28 | 1986-06-26 | NEW SUCCARIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
Country Status (20)
| Country | Link |
|---|---|
| KR (1) | KR870000351A (en) |
| AU (2) | AU596800B2 (en) |
| BE (1) | BE905010A (en) |
| CH (1) | CH672789A5 (en) |
| DE (1) | DE3621122A1 (en) |
| DK (1) | DK304286A (en) |
| ES (2) | ES2000205A6 (en) |
| FI (2) | FI862723A (en) |
| FR (1) | FR2584076A1 (en) |
| GB (1) | GB2179945B (en) |
| HU (1) | HU199494B (en) |
| IL (2) | IL79247A0 (en) |
| IT (1) | IT1203816B (en) |
| LU (1) | LU86491A1 (en) |
| NL (1) | NL8601551A (en) |
| PH (1) | PH24438A (en) |
| PL (2) | PL151036B1 (en) |
| PT (1) | PT82855B (en) |
| SE (1) | SE8602854L (en) |
| WO (1) | WO1987000174A2 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3731953A1 (en) | 1987-09-23 | 1989-04-06 | Sandoz Ag | NEW SACCHARID, METHOD FOR THEIR PRODUCTION AND THEIR USE |
| DE68926746T2 (en) * | 1988-08-19 | 1996-11-28 | Univ Australian | ANTI-FLAMMABLE AND / OR IMMUNITY-SUPPRESSING MEDICINE-BASED MEDICINAL PRODUCTS |
| AU627500B2 (en) * | 1988-08-19 | 1992-08-27 | Australian National University, The | Phosphosugar-based anti-inflammatory and/or immunosuppressive drugs |
| US5158939A (en) * | 1989-07-21 | 1992-10-27 | Wisconsin Alumni Research Foundation | Method of stimulating the immune systems of animals and compositions useful therefor |
| RU1836378C (en) * | 1989-12-11 | 1993-08-23 | Санкио Компани Лимитед | Method for obtaining lipid a analogues |
| AU660325B2 (en) * | 1991-10-11 | 1995-06-22 | Eisai Co. Ltd. | Anti-endotoxin compounds and related molecules and methods |
| US5530113A (en) * | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
| EP0668289A4 (en) * | 1993-09-07 | 1998-10-21 | Suntory Ltd | Novel disaccharide derivative. |
| US5681824A (en) * | 1995-06-05 | 1997-10-28 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| DE19740357A1 (en) * | 1997-09-13 | 1999-03-18 | Martin Wilhelm | New sugar phosphate compounds |
| CN113214329A (en) * | 2020-01-21 | 2021-08-06 | 上海医药工业研究院 | Preparation method of Lipid X and intermediate thereof, and intermediate thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL37955A0 (en) * | 1970-11-13 | 1971-12-29 | Ciba Geigy Ag | O-esters of monosaccharides,their manufacture and pharmaceutical compositions containing them |
| JPS60501259A (en) * | 1983-05-06 | 1985-08-08 | ウイスコンシン・アルムニ・リサ−チ・フアンデ−シヨン | Monosaccharide compounds with immunostimulatory activity |
| US4698331A (en) * | 1984-04-21 | 1987-10-06 | Sandoz Ltd. | 2,3-diamino-2,3-didesoxyhexose derivatives and their use |
| GR860379B (en) * | 1985-02-22 | 1986-06-11 | Akzo Nv | Novel disaccharide and trisaccharide derivatives of the lipid a type |
-
1986
- 1986-06-16 NL NL8601551A patent/NL8601551A/en not_active Application Discontinuation
- 1986-06-16 HU HU862535A patent/HU199494B/en not_active IP Right Cessation
- 1986-06-23 CH CH2515/86A patent/CH672789A5/de not_active IP Right Cessation
- 1986-06-24 DE DE19863621122 patent/DE3621122A1/en not_active Withdrawn
- 1986-06-24 WO PCT/EP1986/000366 patent/WO1987000174A2/en unknown
- 1986-06-26 IL IL79247A patent/IL79247A0/en unknown
- 1986-06-26 PT PT82855A patent/PT82855B/en not_active IP Right Cessation
- 1986-06-26 SE SE8602854A patent/SE8602854L/en not_active Application Discontinuation
- 1986-06-26 DK DK304286A patent/DK304286A/en not_active Application Discontinuation
- 1986-06-26 PH PH33950A patent/PH24438A/en unknown
- 1986-06-26 GB GB8615617A patent/GB2179945B/en not_active Expired
- 1986-06-26 FI FI862723A patent/FI862723A/en not_active Application Discontinuation
- 1986-06-27 PL PL1986260328A patent/PL151036B1/en unknown
- 1986-06-27 KR KR1019860005166A patent/KR870000351A/en not_active Application Discontinuation
- 1986-06-27 BE BE1/011511A patent/BE905010A/en not_active IP Right Cessation
- 1986-06-27 AU AU59313/86A patent/AU596800B2/en not_active Ceased
- 1986-06-27 LU LU86491A patent/LU86491A1/en unknown
- 1986-06-27 FR FR8609350A patent/FR2584076A1/en active Pending
- 1986-06-27 PL PL1986271248A patent/PL151094B1/en unknown
- 1986-06-27 ES ES868600029A patent/ES2000205A6/en not_active Expired
- 1986-06-30 IT IT48204/86A patent/IT1203816B/en active
-
1987
- 1987-10-16 ES ES8702969A patent/ES2013323A6/en not_active Expired - Lifetime
-
1989
- 1989-10-03 IL IL91862A patent/IL91862A0/en unknown
-
1990
- 1990-01-16 AU AU47989/90A patent/AU4798990A/en not_active Abandoned
- 1990-02-06 FI FI900588A patent/FI900588A0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| LU86491A1 (en) | 1987-01-13 |
| AU4798990A (en) | 1990-05-10 |
| WO1987000174A2 (en) | 1987-01-15 |
| AU5931386A (en) | 1987-01-08 |
| GB8615617D0 (en) | 1986-07-30 |
| GB2179945A (en) | 1987-03-18 |
| WO1987000174A3 (en) | 1987-10-22 |
| CH672789A5 (en) | 1989-12-29 |
| ES2013323A6 (en) | 1990-05-01 |
| FI862723A0 (en) | 1986-06-26 |
| GB2179945B (en) | 1989-11-15 |
| BE905010A (en) | 1986-12-29 |
| PL271248A1 (en) | 1989-01-23 |
| PT82855A (en) | 1986-07-01 |
| DK304286D0 (en) | 1986-06-26 |
| FI900588A0 (en) | 1990-02-06 |
| HU199494B (en) | 1990-02-28 |
| FR2584076A1 (en) | 1987-01-02 |
| PL151094B1 (en) | 1990-07-31 |
| IL91862A0 (en) | 1990-06-10 |
| IT1203816B (en) | 1989-02-23 |
| IT8648204A0 (en) | 1986-06-30 |
| PH24438A (en) | 1990-06-25 |
| ES2000205A6 (en) | 1988-01-16 |
| FI862723A (en) | 1986-12-29 |
| SE8602854L (en) | 1986-12-29 |
| PT82855B (en) | 1988-12-15 |
| HUT42499A (en) | 1987-07-28 |
| KR870000351A (en) | 1987-02-18 |
| PL151036B1 (en) | 1990-07-31 |
| IL79247A0 (en) | 1986-09-30 |
| AU596800B2 (en) | 1990-05-17 |
| NL8601551A (en) | 1987-01-16 |
| DK304286A (en) | 1986-12-29 |
| DE3621122A1 (en) | 1987-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8602854-5 Effective date: 19910524 |