SE398116B - ANALOGICAL PROCEDURE FOR THE PREPARATION OF CYCLOHEXENYL UCARBAMIDES - Google Patents

ANALOGICAL PROCEDURE FOR THE PREPARATION OF CYCLOHEXENYL UCARBAMIDES

Info

Publication number
SE398116B
SE398116B SE7503522A SE7503522A SE398116B SE 398116 B SE398116 B SE 398116B SE 7503522 A SE7503522 A SE 7503522A SE 7503522 A SE7503522 A SE 7503522A SE 398116 B SE398116 B SE 398116B
Authority
SE
Sweden
Prior art keywords
ucarbamides
cyclohexenyl
preparation
carbon atoms
oxocyclohex
Prior art date
Application number
SE7503522A
Other languages
Swedish (sv)
Other versions
SE7503522L (en
Inventor
P E Aldrich
G H Berezin
B I Dittmar
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/555,308 external-priority patent/US4002767A/en
Application filed by Du Pont filed Critical Du Pont
Publication of SE7503522L publication Critical patent/SE7503522L/en
Publication of SE398116B publication Critical patent/SE398116B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

3-Oxocyclohex-1-en-1-ylureas of the formula (I) <IMAGE> in which R1, R2 and R3 denote alkyl groups having 1 to 3 carbon atoms or alkenyl groups having 2 to 3 carbon atoms, where the total number of the carbon atoms of R1, R2 and R3 does not exceed five and two of the radicals R1, R2 and R3 can be bonded to one another to form a cycloalkyl or cycloalkenyl group, preferably 1-tert-butyl-3-(3-oxocyclohex-1-en-1-yl)urea, exhibit antihypertensive activity in mammals. The said compounds are obtained by reaction of a compound of the formula II <IMAGE> with 1,3-cyclohexanedione.
SE7503522A 1974-04-17 1975-03-26 ANALOGICAL PROCEDURE FOR THE PREPARATION OF CYCLOHEXENYL UCARBAMIDES SE398116B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46169774A 1974-04-17 1974-04-17
US52544574A 1974-11-20 1974-11-20
US05/555,308 US4002767A (en) 1974-11-20 1975-03-11 1-Tertiary-alkyl-3-(substituted cyclohexenyl)ureas as antihypertensive agents

Publications (2)

Publication Number Publication Date
SE7503522L SE7503522L (en) 1975-10-20
SE398116B true SE398116B (en) 1977-12-05

Family

ID=27412847

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7503522A SE398116B (en) 1974-04-17 1975-03-26 ANALOGICAL PROCEDURE FOR THE PREPARATION OF CYCLOHEXENYL UCARBAMIDES

Country Status (18)

Country Link
JP (1) JPS50148337A (en)
AR (1) AR206020A1 (en)
CA (1) CA1051029A (en)
CH (1) CH611273A5 (en)
DD (1) DD119223A5 (en)
DE (1) DE2516556A1 (en)
DK (1) DK134318B (en)
ES (1) ES436647A1 (en)
FI (1) FI751127A (en)
FR (1) FR2267766B1 (en)
GB (1) GB1457245A (en)
IE (1) IE40999B1 (en)
IL (1) IL47097A (en)
LU (1) LU72305A1 (en)
NL (1) NL7504568A (en)
NO (1) NO751350L (en)
PH (1) PH11869A (en)
SE (1) SE398116B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2424162A1 (en) * 1978-04-24 1979-11-23 British Hovercraft Corp Ltd Aircushon vehicle skirt rip stopper - has flexible core chemically bonded in fabric reinforced elastomer sheath with tensile load path discontinuities
EP0004959A1 (en) * 1978-04-24 1979-10-31 Ciba-Geigy Ag Process for preparing 3-oxo-cyclopentenyl ureas, compounds thus obtained, pharmaceutical compositions containing them and 3-oxo-cyclopentenylisothio ureas
EP0278907B1 (en) * 1987-02-09 1991-05-29 Ciba-Geigy Ag Cyclohexane diones

Also Published As

Publication number Publication date
GB1457245A (en) 1976-12-01
DK134318C (en) 1977-04-18
ES436647A1 (en) 1977-08-01
IE40999L (en) 1975-10-17
DD119223A5 (en) 1976-04-12
NL7504568A (en) 1975-10-21
SE7503522L (en) 1975-10-20
PH11869A (en) 1978-08-04
DE2516556A1 (en) 1975-10-30
IE40999B1 (en) 1979-09-26
JPS50148337A (en) 1975-11-27
FR2267766A1 (en) 1975-11-14
DK134318B (en) 1976-10-18
NO751350L (en) 1975-10-20
CA1051029A (en) 1979-03-20
FR2267766B1 (en) 1978-10-06
IL47097A (en) 1978-03-10
FI751127A (en) 1975-10-18
AU8013475A (en) 1976-10-21
CH611273A5 (en) 1979-05-31
AR206020A1 (en) 1976-06-23
DK163975A (en) 1975-10-18
LU72305A1 (en) 1976-03-17
IL47097A0 (en) 1975-06-25

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