SE8404005D0 - 4'-HALOGENANTRACYKLINGLYKOSIDER - Google Patents

4'-HALOGENANTRACYKLINGLYKOSIDER

Info

Publication number
SE8404005D0
SE8404005D0 SE8404005A SE8404005A SE8404005D0 SE 8404005 D0 SE8404005 D0 SE 8404005D0 SE 8404005 A SE8404005 A SE 8404005A SE 8404005 A SE8404005 A SE 8404005A SE 8404005 D0 SE8404005 D0 SE 8404005D0
Authority
SE
Sweden
Prior art keywords
those
prepared
reaction
halogenantracyklinglykosider
4ncl
Prior art date
Application number
SE8404005A
Other languages
Swedish (sv)
Other versions
SE8404005L (en
Inventor
A Suarato
S Penco
F Giuliani
F Arcamone
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of SE8404005D0 publication Critical patent/SE8404005D0/en
Publication of SE8404005L publication Critical patent/SE8404005L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

<IMAGE> Compounds of the above formula (X=H or OH, R1=H, OH or OCH3, R2=Br, Cl or F) and their acid addition salts are useful as antitumour agents. Those in which X=H may be prepared by an exchange reaction between a 4'-epi-4'-O-trifluoromethanesulphonyl-N-protected-daunorubicin (or a corresponding 4-demethyl or 4-demethoxy derivative) and (C4H9)4NCl, (C4H9)4NBr or CsF. Those in which X=OH are prepared from those in which X=H by bromination and reaction with aqueous sodium formate.
SE8404005A 1983-08-11 1984-08-07 4'-HALOGENANTRACYKLINGLYKOSIDER SE8404005L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838321676A GB8321676D0 (en) 1983-08-11 1983-08-11 4'-haloanthrocycline glycosides

Publications (2)

Publication Number Publication Date
SE8404005D0 true SE8404005D0 (en) 1984-08-07
SE8404005L SE8404005L (en) 1985-02-12

Family

ID=10547171

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8404005A SE8404005L (en) 1983-08-11 1984-08-07 4'-HALOGENANTRACYKLINGLYKOSIDER

Country Status (19)

Country Link
JP (1) JPS6058997A (en)
AT (1) AT384226B (en)
AU (1) AU563396B2 (en)
BE (1) BE900336A (en)
CA (1) CA1250833A (en)
CH (1) CH660740A5 (en)
CS (1) CS270411B2 (en)
DE (1) DE3428945A1 (en)
DK (1) DK381884A (en)
FI (1) FI78109C (en)
FR (1) FR2554450B1 (en)
GB (2) GB8321676D0 (en)
GR (1) GR80046B (en)
HU (1) HU194266B (en)
IT (1) IT1209576B (en)
NL (1) NL8402477A (en)
SE (1) SE8404005L (en)
SU (1) SU1579465A3 (en)
ZA (1) ZA846147B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159518A (en) * 1984-06-08 1985-12-04 Erba Farmitalia New anthracyclines and process for manufacture
GB8414619D0 (en) * 1984-06-08 1984-07-11 Erba Farmitalia Anthracyclines
DE3500017A1 (en) * 1985-01-02 1986-07-10 Farmitalia Carlo Erba S.p.A., Mailand/Milano 4'-Haloanthracycline esters
GB2218087B (en) * 1988-04-22 1991-01-30 Erba Carlo Spa 4-demethoxy-4'-deoxy-4'iodo anthracycline glycosides
AU601857B2 (en) * 1988-06-30 1990-09-20 Pharmacia & Upjohn S.P.A. A new antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin
MA21995A1 (en) * 1989-11-13 1991-07-01 Menarini Farma Ind NOVEL FLUORONAPHTHACENEDIONES, THEIR GLYCOZYL DERIVATIVES AND THEIR MANUFACTURING METHODS.
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR892943A (en) * 1942-03-06 1944-05-24 Ig Farbenindustrie Ag Process for purifying gamma-keto-pimelic dilactone
US4345070A (en) * 1980-09-29 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides

Also Published As

Publication number Publication date
FI843110A (en) 1985-02-12
NL8402477A (en) 1985-03-01
SE8404005L (en) 1985-02-12
BE900336A (en) 1985-02-11
IT1209576B (en) 1989-08-30
FI843110A0 (en) 1984-08-08
AT384226B (en) 1987-10-12
FI78109C (en) 1989-06-12
ATA253884A (en) 1987-03-15
HUT35691A (en) 1985-07-29
AU563396B2 (en) 1987-07-09
FI78109B (en) 1989-02-28
DE3428945A1 (en) 1985-02-28
GB2144744A (en) 1985-03-13
AU3168584A (en) 1985-02-14
GB2144744B (en) 1986-12-03
DK381884D0 (en) 1984-08-08
ZA846147B (en) 1985-03-27
CA1250833A (en) 1989-03-07
GB8321676D0 (en) 1983-09-14
HU194266B (en) 1988-01-28
GB8420237D0 (en) 1984-09-12
FR2554450B1 (en) 1987-01-30
SU1579465A3 (en) 1990-07-15
DK381884A (en) 1985-02-12
FR2554450A1 (en) 1985-05-10
IT8422232A0 (en) 1984-08-06
CH660740A5 (en) 1987-06-15
CS605284A2 (en) 1989-11-14
GR80046B (en) 1984-12-10
JPS6058997A (en) 1985-04-05
CS270411B2 (en) 1990-06-13

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