BE900336A - 4'-HALO-ANTHRACYCLINE GLYCOSIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICAMENT - Google Patents

4'-HALO-ANTHRACYCLINE GLYCOSIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICAMENT

Info

Publication number
BE900336A
BE900336A BE0/213475A BE213475A BE900336A BE 900336 A BE900336 A BE 900336A BE 0/213475 A BE0/213475 A BE 0/213475A BE 213475 A BE213475 A BE 213475A BE 900336 A BE900336 A BE 900336A
Authority
BE
Belgium
Prior art keywords
halo
medicament
preparation
anthracycline glycosides
prepared
Prior art date
Application number
BE0/213475A
Other languages
French (fr)
Inventor
A Suarato
S Penco
F Giuliani
F Arcamone
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE900336A publication Critical patent/BE900336A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Les composés ayant la formule (I) (X=H ou OH; R1=H, OH ou OCH3; R2=Br, C2 ou F) et leurs sels d'addition acide sont utiles comme agents anti-tumoraux; ceux dans lesquels X=H se préparent par une réaction d'échange entre la 4'-épi-4'-O-trifluorométhanesulfonyl-N-protégédaunorubicine (ou un dérivé 4-déméthyle ou 4-déméthoxy corresponant) et (C4H9) 4NC2 ou (C4H9) 4NBr ou C5F; ceux dans lesquels X=OH sont préparées à partir des précédents par bromation et réaction avec du formiate de sodium aqueux.The compounds having the formula (I) (X = H or OH; R1 = H, OH or OCH3; R2 = Br, C2 or F) and their acid addition salts are useful as anti-tumor agents; those in which X = H is prepared by an exchange reaction between the 4'-epi-4'-O-trifluoromethanesulfonyl-N-protected byunorubicin (or a corresponding 4-demethyl or 4-demethoxy derivative) and (C4H9) 4NC2 or (C4H9) 4NBr or C5F; those in which X = OH are prepared from the preceding ones by bromination and reaction with aqueous sodium formate.

BE0/213475A 1983-08-11 1984-08-10 4'-HALO-ANTHRACYCLINE GLYCOSIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICAMENT BE900336A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838321676A GB8321676D0 (en) 1983-08-11 1983-08-11 4'-haloanthrocycline glycosides

Publications (1)

Publication Number Publication Date
BE900336A true BE900336A (en) 1985-02-11

Family

ID=10547171

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213475A BE900336A (en) 1983-08-11 1984-08-10 4'-HALO-ANTHRACYCLINE GLYCOSIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICAMENT

Country Status (19)

Country Link
JP (1) JPS6058997A (en)
AT (1) AT384226B (en)
AU (1) AU563396B2 (en)
BE (1) BE900336A (en)
CA (1) CA1250833A (en)
CH (1) CH660740A5 (en)
CS (1) CS270411B2 (en)
DE (1) DE3428945A1 (en)
DK (1) DK381884A (en)
FI (1) FI78109C (en)
FR (1) FR2554450B1 (en)
GB (2) GB8321676D0 (en)
GR (1) GR80046B (en)
HU (1) HU194266B (en)
IT (1) IT1209576B (en)
NL (1) NL8402477A (en)
SE (1) SE8404005L (en)
SU (1) SU1579465A3 (en)
ZA (1) ZA846147B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159518A (en) * 1984-06-08 1985-12-04 Erba Farmitalia New anthracyclines and process for manufacture
GB8414619D0 (en) * 1984-06-08 1984-07-11 Erba Farmitalia Anthracyclines
DE3500017A1 (en) * 1985-01-02 1986-07-10 Farmitalia Carlo Erba S.p.A., Mailand/Milano 4'-Haloanthracycline esters
GB2218087B (en) * 1988-04-22 1991-01-30 Erba Carlo Spa 4-demethoxy-4'-deoxy-4'iodo anthracycline glycosides
AU601857B2 (en) * 1988-06-30 1990-09-20 Pharmacia & Upjohn S.P.A. A new antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin
MA21995A1 (en) * 1989-11-13 1991-07-01 Menarini Farma Ind NOVEL FLUORONAPHTHACENEDIONES, THEIR GLYCOZYL DERIVATIVES AND THEIR MANUFACTURING METHODS.
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR892943A (en) * 1942-03-06 1944-05-24 Ig Farbenindustrie Ag Process for purifying gamma-keto-pimelic dilactone
US4345070A (en) * 1980-09-29 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides

Also Published As

Publication number Publication date
IT8422232A0 (en) 1984-08-06
GR80046B (en) 1984-12-10
CH660740A5 (en) 1987-06-15
IT1209576B (en) 1989-08-30
DK381884D0 (en) 1984-08-08
GB2144744A (en) 1985-03-13
AU3168584A (en) 1985-02-14
HUT35691A (en) 1985-07-29
DK381884A (en) 1985-02-12
ATA253884A (en) 1987-03-15
JPS6058997A (en) 1985-04-05
NL8402477A (en) 1985-03-01
SE8404005D0 (en) 1984-08-07
FR2554450A1 (en) 1985-05-10
FI843110A0 (en) 1984-08-08
GB2144744B (en) 1986-12-03
AU563396B2 (en) 1987-07-09
DE3428945A1 (en) 1985-02-28
AT384226B (en) 1987-10-12
FI78109C (en) 1989-06-12
GB8321676D0 (en) 1983-09-14
ZA846147B (en) 1985-03-27
FI843110A (en) 1985-02-12
FR2554450B1 (en) 1987-01-30
CA1250833A (en) 1989-03-07
FI78109B (en) 1989-02-28
CS270411B2 (en) 1990-06-13
SE8404005L (en) 1985-02-12
SU1579465A3 (en) 1990-07-15
HU194266B (en) 1988-01-28
CS605284A2 (en) 1989-11-14
GB8420237D0 (en) 1984-09-12

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19900831