SE8401491D0 - INTERMEDIATES FOR MANUFACTURING H? 712 RECEPTOR ANTAGONISTS - Google Patents

INTERMEDIATES FOR MANUFACTURING H? 712 RECEPTOR ANTAGONISTS

Info

Publication number
SE8401491D0
SE8401491D0 SE8401491A SE8401491A SE8401491D0 SE 8401491 D0 SE8401491 D0 SE 8401491D0 SE 8401491 A SE8401491 A SE 8401491A SE 8401491 A SE8401491 A SE 8401491A SE 8401491 D0 SE8401491 D0 SE 8401491D0
Authority
SE
Sweden
Prior art keywords
intermediates
manufacturing
receptor antagonists
antagonists
chain
Prior art date
Application number
SE8401491A
Other languages
Swedish (sv)
Other versions
SE8401491L (en
Inventor
R R Crenshaw
G M Luke
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/848,959 external-priority patent/US4112234A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8401491L publication Critical patent/SE8401491L/en
Publication of SE8401491D0 publication Critical patent/SE8401491D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Antagonists of histamine H2 receptors, which antagonists inhibit gastric secretion in animals and are suitable for treating ulcerous disorders, have the following formula <IMAGE> in which R<2> represents a straight-chain or branched-chain alkynyl group having 3-9 C atoms, including non-toxic, pharmaceutically useful, acid addition salts thereof. Starting materials for preparing the said compounds and processes for their preparation.
SE8401491A 1977-06-03 1984-03-16 INTERMEDIATES FOR MANUFACTURING H? 712 RECEPTOR ANTAGONISTS SE8401491D0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80300977A 1977-06-03 1977-06-03
US82679677A 1977-08-22 1977-08-22
US05/848,959 US4112234A (en) 1977-08-22 1977-11-07 Imidazolylmethylthioethyl alkynyl guanidines

Publications (2)

Publication Number Publication Date
SE8401491L SE8401491L (en) 1984-03-16
SE8401491D0 true SE8401491D0 (en) 1984-03-16

Family

ID=27419995

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7806525A SE443784B (en) 1977-06-03 1978-06-02 NEW ASSOCIATIONS WITH PHARMACOLOGICAL EFFECT
SE8401492A SE8401492D0 (en) 1977-06-03 1984-03-16 INTERMEDIATES FOR MANUFACTURING H? 712 RECEPTOR ANTAGONISTS
SE8401491A SE8401491D0 (en) 1977-06-03 1984-03-16 INTERMEDIATES FOR MANUFACTURING H? 712 RECEPTOR ANTAGONISTS

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SE7806525A SE443784B (en) 1977-06-03 1978-06-02 NEW ASSOCIATIONS WITH PHARMACOLOGICAL EFFECT
SE8401492A SE8401492D0 (en) 1977-06-03 1984-03-16 INTERMEDIATES FOR MANUFACTURING H? 712 RECEPTOR ANTAGONISTS

Country Status (26)

Country Link
JP (1) JPS543067A (en)
AR (2) AR222797A1 (en)
CA (1) CA1110251A (en)
CH (2) CH641167A5 (en)
CY (3) CY1231A (en)
DD (1) DD140038A5 (en)
DE (1) DE2824066A1 (en)
DK (1) DK243178A (en)
ES (3) ES470474A1 (en)
FI (1) FI69069C (en)
FR (2) FR2401143A1 (en)
GB (3) GB1598629A (en)
GR (1) GR73860B (en)
HK (3) HK38184A (en)
HU (1) HU186766B (en)
IE (1) IE47543B1 (en)
IL (1) IL54819A (en)
KE (1) KE3373A (en)
LU (1) LU79725A1 (en)
MY (3) MY8500451A (en)
NL (1) NL7805935A (en)
NO (3) NO152214C (en)
NZ (1) NZ187376A (en)
SE (3) SE443784B (en)
SG (1) SG8584G (en)
YU (4) YU129778A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4339439A (en) * 1981-01-19 1982-07-13 Bristol-Myers Company Pharmaceutical methods and compositions
JPS57134318A (en) * 1981-02-12 1982-08-19 Nissan Motor Co Ltd Air mixing construction of air conditioner
JPS5848516U (en) * 1981-09-30 1983-04-01 日産車体株式会社 Vehicle air conditioner
JPS6018010U (en) * 1983-07-18 1985-02-07 日産自動車株式会社 Temperature adjustment mechanism of vehicle air conditioner
JPS60113211U (en) * 1984-01-06 1985-07-31 松下電器産業株式会社 Automotive air conditioner
ES2007948A6 (en) * 1988-07-06 1989-07-01 Vinas Lab Propargylguanidine derivatives and process for the preparation thereof.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024271A (en) * 1971-03-09 1977-05-17 Smith Kline & French Laboratories Limited Pharmacologically active guanidine compounds
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1531221A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives

Also Published As

Publication number Publication date
KE3373A (en) 1984-03-23
HK38284A (en) 1984-05-11
ES478203A1 (en) 1979-06-01
NO151824C (en) 1985-06-12
ES470474A1 (en) 1979-09-01
MY8500451A (en) 1985-12-31
SE8401492L (en) 1984-03-16
FR2436138A1 (en) 1980-04-11
NO152214C (en) 1985-08-28
FR2401143B1 (en) 1981-12-11
HU186766B (en) 1985-09-30
JPS5639313B2 (en) 1981-09-11
GB1598630A (en) 1981-09-23
MY8500452A (en) 1985-12-31
CY1229A (en) 1984-06-29
SE8401491L (en) 1984-03-16
IL54819A0 (en) 1978-07-31
NO781928L (en) 1978-12-05
AR222797A1 (en) 1981-06-30
SG8584G (en) 1985-02-08
FR2401143A1 (en) 1979-03-23
NO791637L (en) 1978-12-05
LU79725A1 (en) 1979-02-02
NO833255L (en) 1978-12-05
YU215482A (en) 1983-02-28
NL7805935A (en) 1978-12-05
CY1230A (en) 1984-06-29
SE7806525L (en) 1978-12-04
IL54819A (en) 1983-03-31
CA1110251A (en) 1981-10-06
MY8500453A (en) 1985-12-31
IE781112L (en) 1978-12-03
DD140038A5 (en) 1980-02-06
SE443784B (en) 1986-03-10
YU40625B (en) 1986-02-28
DK243178A (en) 1978-12-04
NZ187376A (en) 1981-05-29
YU40624B (en) 1986-02-28
JPS543067A (en) 1979-01-11
SE8401492D0 (en) 1984-03-16
CY1231A (en) 1984-06-29
HK38084A (en) 1984-05-11
HK38184A (en) 1984-05-11
GB1598628A (en) 1981-09-23
IE47543B1 (en) 1984-04-18
FI69069B (en) 1985-08-30
YU41620B (en) 1987-12-31
YU53079A (en) 1983-09-30
FR2436138B1 (en) 1982-12-03
GB1598629A (en) 1981-09-23
FI69069C (en) 1985-12-10
YU215582A (en) 1983-02-28
FI781737A (en) 1978-12-04
CH641167A5 (en) 1984-02-15
GR73860B (en) 1984-05-08
ES478202A1 (en) 1979-06-01
YU129778A (en) 1983-02-28
DE2824066A1 (en) 1978-12-14
CH644591A5 (en) 1984-08-15
AR222503A1 (en) 1981-05-29
NO152214B (en) 1985-05-13
NO151824B (en) 1985-03-04

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