SE8400688L - NEW PHARMACOLOGICALLY ACTIVE SOCIETIES - Google Patents

NEW PHARMACOLOGICALLY ACTIVE SOCIETIES

Info

Publication number
SE8400688L
SE8400688L SE8400688A SE8400688A SE8400688L SE 8400688 L SE8400688 L SE 8400688L SE 8400688 A SE8400688 A SE 8400688A SE 8400688 A SE8400688 A SE 8400688A SE 8400688 L SE8400688 L SE 8400688L
Authority
SE
Sweden
Prior art keywords
alkoxy
aryl
alkyl
alkylamino
opt
Prior art date
Application number
SE8400688A
Other languages
Swedish (sv)
Other versions
SE8400688D0 (en
Inventor
A E Brendstrom
S A I Carlsson
B I M Kellsson
P L Lindberg
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE8300736A external-priority patent/SE8300736D0/en
Application filed by Haessle Ab filed Critical Haessle Ab
Priority to SE8400688A priority Critical patent/SE8400688L/en
Publication of SE8400688D0 publication Critical patent/SE8400688D0/en
Publication of SE8400688L publication Critical patent/SE8400688L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Cpds. of formula (I) and their salts when X is S are new:- X=S or -S(O)-; R15=H, CH3 or C2H5; R1, R2, R3, R4=same or different H, halo, CN, -CHO, CF3, -COR'', -CH(OR13)2, -(Z)n-A-D, aryl, aryloxy, 1-6C alkylthio, NO2, 1-6C alkylsulphinyl or adjacent gps. R1, R2, R3, R4 together form a 5,6 or 7 membered monocyclic ring or 9, 10 or 11 membered bicyclic Mg both opt. unsatd. and opt. contg. 0 to 3 of N and/or O fused to the benzimidazole ring. R11 and R12=same or different aryl, 1-4C alkoxy, 1-3C alkoxy (1-3C) alkoxy, aryl (1-2C) alkoxy, aryloxy, di(1-3C)alkylamino, pyrrolidino or piperidino both opt. substd. by 1-3C alkyl; R13=1-4C alkyl or 2-3C alkylene; Z=-O- or -C(=O)-; L=0 or 1; A=1-6C alkylene, 3-6C cycloalkylene, 2-6C alkylene, 3-6C cycloalkylene or 2-6C alkynylene; D=CN, -C(=O)R9, -(Y)m-(C=O)r-R16; R9=1-5C alkoxy or di(1-3C)alkylamino; m=O or 1; r=O or 1; y=-O-, -NH-, -NR10-; R10=H, 1-3C alkyl, aryl(1-2C) alkyl or aryl; R5=H or -CO-R14; R14=1-6C alkyl, aryl(1-2C) alkyl, aryl, 1-4C alkoxy, aryl(1-2C) alkyl, aryloxy, amino, mono- or di-(1-4C) alkylamino, aryl(1-2C) alkylamino or arylamino; R6 and R8=same or different H, or 1-5C alkyl; R7=1-8C alkyl, 1-8C alkoxy, 2-5C alkenyloxy, 2-5C alkynyloxy, 1-2C alkoxy (1-2C) alkoxy, di(1-2C) alkylamino (1-4C) alkoxy, 3-7C oxacycloalkyl, 4-7C oxacycloalkoxy, 4-7C oxacycloalkylalkyl, 4-6C oxacycloalkylalkoxy R6 and R7 or R7 and R8 together with the adjacent carbon atoms in the pyridine form a ring where R6 and R7 or R7 and R8 is -CH=CH-CH=CH-, -O-(CH2)p-, -CH2(CH2)p-, -O-CH=CH-, -NH-CH=CH- or -N(CH3)CH=CH- p=2,3 or 4.(0/0)
SE8400688A 1983-02-11 1984-02-09 NEW PHARMACOLOGICALLY ACTIVE SOCIETIES SE8400688L (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE8400688A SE8400688L (en) 1983-02-11 1984-02-09 NEW PHARMACOLOGICALLY ACTIVE SOCIETIES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8300736A SE8300736D0 (en) 1983-02-11 1983-02-11 NOVEL PHARMACOLOGICALLY ACTIVE COMPOUNDS
SE8400688A SE8400688L (en) 1983-02-11 1984-02-09 NEW PHARMACOLOGICALLY ACTIVE SOCIETIES

Publications (2)

Publication Number Publication Date
SE8400688D0 SE8400688D0 (en) 1984-02-09
SE8400688L true SE8400688L (en) 1984-08-12

Family

ID=26658388

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8400688A SE8400688L (en) 1983-02-11 1984-02-09 NEW PHARMACOLOGICALLY ACTIVE SOCIETIES

Country Status (1)

Country Link
SE (1) SE8400688L (en)

Also Published As

Publication number Publication date
SE8400688D0 (en) 1984-02-09

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