PT82558A - Process for the preparation of morphinan derivatives - Google Patents

Process for the preparation of morphinan derivatives

Info

Publication number
PT82558A
PT82558A PT8255886A PT8255886A PT82558A PT 82558 A PT82558 A PT 82558A PT 8255886 A PT8255886 A PT 8255886A PT 8255886 A PT8255886 A PT 8255886A PT 82558 A PT82558 A PT 82558A
Authority
PT
Portugal
Prior art keywords
alkyl
phenyl
cyclopropylmethyl
preparation
morphinan derivatives
Prior art date
Application number
PT8255886A
Other languages
Portuguese (pt)
Other versions
PT82558B (en
Inventor
Laszlo Revesz
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Priority to PT8255886A priority Critical patent/PT82558B/en
Publication of PT82558A publication Critical patent/PT82558A/en
Publication of PT82558B publication Critical patent/PT82558B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Morphinan derivs. of formula (I) and their esters and acid-addn. salts are new. X and Y are H or X+Y is O; R1 is allyl (opt. substd. by 1-3 alkyl gps. with a total of 1-3C), cyclopropylmethyl or 3-furylmethyl; R2 is H, 1-10C alkyl, 5-6C cycloalkyl or opt. substd. phenyl or 7-12C phenylalkyl; R3 is H, 1-10C alkyl or phenyl; R4 is H, OH, NR6R7, NHCOR, NHSO2R' or NHCOOR'' or R3+R4 is O or CH2; R6 and R7 are H or 1-3C alkyl; R is 1-6C alkyl, phenyl or ACOOR''; A is 2-4C alkylene or alkenylene; R' is 1-6C alkyl or phenyl; R'' is Me or Et; R5 is H or Me; provided that (i) R1 is not cyclopropylmethyl or allyl when X+Y is O, R2 is H, R4 is alpha-OH and R3 is R5 is H and (ii) R1 is not cyclopropylmethyl when R2-R5 are H.
PT8255886A 1986-05-09 1986-05-09 Process for the preparation of morphinan derivatives PT82558B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PT8255886A PT82558B (en) 1986-05-09 1986-05-09 Process for the preparation of morphinan derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT8255886A PT82558B (en) 1986-05-09 1986-05-09 Process for the preparation of morphinan derivatives

Publications (2)

Publication Number Publication Date
PT82558A true PT82558A (en) 1986-06-01
PT82558B PT82558B (en) 1988-04-12

Family

ID=20083834

Family Applications (1)

Application Number Title Priority Date Filing Date
PT8255886A PT82558B (en) 1986-05-09 1986-05-09 Process for the preparation of morphinan derivatives

Country Status (1)

Country Link
PT (1) PT82558B (en)

Also Published As

Publication number Publication date
PT82558B (en) 1988-04-12

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