FR2265369A1 - Opt substd benzo isoindolines - as antiaggressive and analgesic agents of low toxicity - Google Patents
Opt substd benzo isoindolines - as antiaggressive and analgesic agents of low toxicityInfo
- Publication number
- FR2265369A1 FR2265369A1 FR7509429A FR7509429A FR2265369A1 FR 2265369 A1 FR2265369 A1 FR 2265369A1 FR 7509429 A FR7509429 A FR 7509429A FR 7509429 A FR7509429 A FR 7509429A FR 2265369 A1 FR2265369 A1 FR 2265369A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- substd
- antiaggressive
- opt
- isoindolines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Benzoisoindolines (I), their salts and medicaments contg (I) are new: (where R1 H, 1-5C alkyl, 3-7C-cycloalkyl, 3-5C alkenyl or alkynyl, where the double or treble bond is not in the alpha-position to the N atom to which it is linked, 1-4C-alkyl substd. by 3-6C cycloalkyl, 2-hydroxyethyl, 7-11C phenylalkyl opt. substd. in the ring by halogen, or 1-4C-alkyl or alkoxy, or a residue ACOR3 or (CH2)zOCOR6, A is 1-4C alkylene, R3 is 1-5C-alkyl or alkoxy, OH, phenyl opt. substd. by one or two halogen, or NR4R5, R4 and R5 are H or 1-4C alkyl, R6 is 1-4C alkyl, R2 is H, halogen, 1-4C-alkyl or alkoxy, NO2, OH, or NR7R8, R7 is 1-4C alkyl and R8 is H, 1-4C alkyl or 2-4C alkanoyl, but R2 must not be a amino or 1-4C alkylamino when R1 is (CH2)2OCOR6). (I) are antiaggressive agents used for the treatment of psychopaths and the mentally deficient and also as analgesics. Taken orally the toxicity of (I) is low.LD50 >300 mg/kg (mice).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH420074 | 1974-03-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2265369A1 true FR2265369A1 (en) | 1975-10-24 |
| FR2265369B1 FR2265369B1 (en) | 1978-08-04 |
Family
ID=4271654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7509429A Granted FR2265369A1 (en) | 1974-03-26 | 1975-03-26 | Opt substd benzo isoindolines - as antiaggressive and analgesic agents of low toxicity |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS50130755A (en) |
| AU (1) | AU7952675A (en) |
| BE (1) | BE827087A (en) |
| DD (1) | DD118628A5 (en) |
| DE (1) | DE2511621A1 (en) |
| DK (1) | DK107175A (en) |
| FI (1) | FI750763A (en) |
| FR (1) | FR2265369A1 (en) |
| HU (1) | HU169925B (en) |
| IL (1) | IL46909A0 (en) |
| NL (1) | NL7503392A (en) |
| NO (1) | NO750919L (en) |
| SE (1) | SE7503007L (en) |
| ZA (1) | ZA751926B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1599907A (en) * | 1977-04-26 | 1981-10-07 | Glaxo Lab Ltd | Isoindolines |
-
1975
- 1975-03-17 DK DK107175A patent/DK107175A/da unknown
- 1975-03-17 SE SE7503007A patent/SE7503007L/xx unknown
- 1975-03-17 FI FI750763A patent/FI750763A/fi not_active Application Discontinuation
- 1975-03-17 DE DE19752511621 patent/DE2511621A1/en active Pending
- 1975-03-18 NO NO750919A patent/NO750919L/no unknown
- 1975-03-21 NL NL7503392A patent/NL7503392A/en unknown
- 1975-03-24 IL IL46909A patent/IL46909A0/en unknown
- 1975-03-24 HU HUSA2765A patent/HU169925B/hu unknown
- 1975-03-24 BE BE154675A patent/BE827087A/en unknown
- 1975-03-25 DD DD185010A patent/DD118628A5/xx unknown
- 1975-03-25 JP JP50035030A patent/JPS50130755A/ja active Pending
- 1975-03-26 ZA ZA00751926A patent/ZA751926B/en unknown
- 1975-03-26 AU AU79526/75A patent/AU7952675A/en not_active Expired
- 1975-03-26 FR FR7509429A patent/FR2265369A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS50130755A (en) | 1975-10-16 |
| SE7503007L (en) | 1975-09-29 |
| NL7503392A (en) | 1975-09-30 |
| DE2511621A1 (en) | 1976-02-26 |
| AU7952675A (en) | 1976-09-30 |
| ZA751926B (en) | 1976-10-27 |
| FI750763A (en) | 1975-09-27 |
| DK107175A (en) | 1975-09-27 |
| NO750919L (en) | 1975-09-29 |
| HU169925B (en) | 1977-02-28 |
| IL46909A0 (en) | 1975-05-22 |
| BE827087A (en) | 1975-09-24 |
| FR2265369B1 (en) | 1978-08-04 |
| DD118628A5 (en) | 1976-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |