SE8306475D0 - cephalosporin antibiotics - Google Patents

cephalosporin antibiotics

Info

Publication number
SE8306475D0
SE8306475D0 SE8306475A SE8306475A SE8306475D0 SE 8306475 D0 SE8306475 D0 SE 8306475D0 SE 8306475 A SE8306475 A SE 8306475A SE 8306475 A SE8306475 A SE 8306475A SE 8306475 D0 SE8306475 D0 SE 8306475D0
Authority
SE
Sweden
Prior art keywords
gram
cephalosporin antibiotics
toxic
dioxotriazine
tetrazole
Prior art date
Application number
SE8306475A
Other languages
Swedish (sv)
Other versions
SE8306475L (en
Inventor
B E Looker
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SE8306475D0 publication Critical patent/SE8306475D0/en
Publication of SE8306475L publication Critical patent/SE8306475L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Cephalosporin antibiotics of general formula <IMAGE> (wherein Y represents a carbon- linked 5- or 6-membered unsaturated heterocyclic ring containing at least one nitrogen atom, such as pyridine or tetrazole, which ring may also contain one or more sulphur atoms and/or may be substituted by one or more C1-4 alkyl, oxo, hydroxy or carbamoyl-methyl groups such as dioxotriazine), and non-toxic salts and non-toxic metabolically labile esters thereof and pharmaceutical compositions containing them are described. The compounds exhibit broad spectrum antibiotic activity both in vitro and in vivo, having good activity against both Gram-positive and Gram-negative organisms.
SE8306475A 1982-11-24 1983-11-23 cephalosporin antibiotics SE8306475L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8233521 1982-11-24

Publications (2)

Publication Number Publication Date
SE8306475D0 true SE8306475D0 (en) 1983-11-23
SE8306475L SE8306475L (en) 1984-05-25

Family

ID=10534479

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8306475A SE8306475L (en) 1982-11-24 1983-11-23 cephalosporin antibiotics

Country Status (18)

Country Link
JP (1) JPS59106492A (en)
KR (1) KR840006811A (en)
AU (1) AU2161783A (en)
BE (1) BE898293A (en)
DE (1) DE3342317A1 (en)
DK (1) DK535083A (en)
FI (1) FI834297A (en)
FR (1) FR2536402A1 (en)
GB (1) GB2132193B (en)
GR (1) GR79078B (en)
IL (1) IL70310A0 (en)
IT (1) IT1175800B (en)
LU (1) LU85101A1 (en)
NL (1) NL8304024A (en)
NO (1) NO834304L (en)
PT (1) PT77711B (en)
SE (1) SE8306475L (en)
ZA (1) ZA838733B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0148004A3 (en) * 1983-12-30 1986-04-23 Glaxo Group Limited Cephalosporin antibiotics
US5202315A (en) * 1989-05-11 1993-04-13 Lucky, Ltd. Cephalosporin compounds
ES2074224T3 (en) * 1990-03-24 1995-09-01 Lucky Ltd NEW CEPHALOSPORIN INTERMEDIATES AND PROCESS TO PREPARE INTERMEDIATES AND THEIR FINAL PRODUCTS.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
GB2027691B (en) * 1978-05-26 1983-03-02 Glaxo Group Ltd Cephalosporin antibiotics

Also Published As

Publication number Publication date
SE8306475L (en) 1984-05-25
PT77711B (en) 1986-03-27
ZA838733B (en) 1985-01-30
AU2161783A (en) 1984-05-31
KR840006811A (en) 1984-12-03
DE3342317A1 (en) 1984-05-24
GB2132193A (en) 1984-07-04
NO834304L (en) 1984-05-25
LU85101A1 (en) 1984-06-13
IT8349380A0 (en) 1983-11-23
NL8304024A (en) 1984-06-18
GB8331292D0 (en) 1983-12-29
JPS59106492A (en) 1984-06-20
FI834297A0 (en) 1983-11-23
DK535083D0 (en) 1983-11-23
IL70310A0 (en) 1984-02-29
IT1175800B (en) 1987-07-15
FR2536402A1 (en) 1984-05-25
PT77711A (en) 1983-12-01
GR79078B (en) 1984-10-02
DK535083A (en) 1984-05-25
GB2132193B (en) 1985-12-18
BE898293A (en) 1984-05-23
FI834297A (en) 1984-05-25

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Legal Events

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NAV Patent application has lapsed

Ref document number: 8306475-8

Effective date: 19851018