SE8304549L - INTERMEDIATES FOR USE IN THE PROCEDURE FOR PURINES DERIVATIVES - Google Patents

INTERMEDIATES FOR USE IN THE PROCEDURE FOR PURINES DERIVATIVES

Info

Publication number
SE8304549L
SE8304549L SE8304549A SE8304549A SE8304549L SE 8304549 L SE8304549 L SE 8304549L SE 8304549 A SE8304549 A SE 8304549A SE 8304549 A SE8304549 A SE 8304549A SE 8304549 L SE8304549 L SE 8304549L
Authority
SE
Sweden
Prior art keywords
formula
derivatives
guanine
intermediates
compounds
Prior art date
Application number
SE8304549A
Other languages
Swedish (sv)
Other versions
SE447113B (en
SE8304549D0 (en
Inventor
H J Schaeffer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27109837&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE8304549(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/773,135 external-priority patent/US4146715A/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of SE8304549L publication Critical patent/SE8304549L/en
Publication of SE8304549D0 publication Critical patent/SE8304549D0/en
Publication of SE447113B publication Critical patent/SE447113B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

9-(2-Hydroxyethoxymethyl) derivatives of 2-amino-adenine and guanine of formula I are prepared by hydrolysis from compounds of formula II. The reaction is carried out in the presence of a base. The symbols in formula I and II have the meanings given in Patent Claim 1. The novel compounds of formula II are prepared by reacting the guanine or 2-aminoadenine, wherein the 2- and 9-positions, or the 2-, 6- and 9-positions, are acylated, with a diester of 2-oxa-1,4-butanediol. This reaction is carried out in the presence of a catalytic amount of an acid. The 9-(2-hydroxyethoxymethyl) derivatives of 2-aminoadenine and guanine are novel and exhibit an antiviral action, especially against the classes of the DNA- and RNA-viruses.

Claims (2)

PATENTXRAVPATENTXRAV 1. Mellanprodukter for anvandning vii forfarande f5r framstallning av foreningar med formeln (1) 1 (I) CH2.0.CH2'CH2.ON van i R betecknar amino eller hydrox av att de utotires av foreningar tied 1 1 11 0 X -C-NR 111Intermediates for use in a process for the preparation of compounds of the formula (1) 1 (I) CH 2 .0.CH 2 .CH 2 .O 1 in R represents amino or hydroxide in that they are excreted by compounds of X -C -NR 111 2 . 1 van i R betecknar hydroxi eller ^NR2 -C -X1, oCh Xi och X2 dr like a eller olika och betecknar vardera en lagre alkylgrupp, och R2 betecknar vate eller -CX1, varvld R2 betecknar vate, dh Ri tecknar hydroxi. ,kannetecknade formeln (II) (II)2. 1 van in R represents hydroxy or 1 NR 2 -C -X 1, and C 1 X 1 and X 2 are the same or different and each represents a lower alkyl group, and R 2 represents hydrogen or -CX 1, wherein R 2 represents hydrogen, i.e. R 1 represents hydroxy. , jug drawn formula (II) (II)
SE8304549A 1976-08-27 1983-08-23 INTERMEDIATE PRODUCTS FOR THE PREPARATION OF 2-AMINO-9- (2-HYDROXYETHOXIMETHYL) ADENINE AND 9- (2-HYDROXYETHOXIMETHYL) -GUANIN SE447113B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71810576A 1976-08-27 1976-08-27
US05/773,135 US4146715A (en) 1975-08-27 1977-02-28 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines

Publications (3)

Publication Number Publication Date
SE8304549L true SE8304549L (en) 1983-08-23
SE8304549D0 SE8304549D0 (en) 1983-08-23
SE447113B SE447113B (en) 1986-10-27

Family

ID=27109837

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7709606A SE432764B (en) 1976-08-27 1977-08-26 PROCEDURE FOR PREPARING 2-AMINO-9- (2-HYDROXYETOXIMETHYL) ADENIN AND 9- (2-HYDROXYTOXYMETHYL) GUANINE
SE8304549A SE447113B (en) 1976-08-27 1983-08-23 INTERMEDIATE PRODUCTS FOR THE PREPARATION OF 2-AMINO-9- (2-HYDROXYETHOXIMETHYL) ADENINE AND 9- (2-HYDROXYETHOXIMETHYL) -GUANIN

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7709606A SE432764B (en) 1976-08-27 1977-08-26 PROCEDURE FOR PREPARING 2-AMINO-9- (2-HYDROXYETOXIMETHYL) ADENIN AND 9- (2-HYDROXYTOXYMETHYL) GUANINE

Country Status (12)

Country Link
AT (1) AT357566B (en)
CA (2) CA1096863A (en)
CH (1) CH634843A5 (en)
CS (1) CS196384B2 (en)
DD (1) DD131856A6 (en)
DK (1) DK147857C (en)
FI (1) FI64160C (en)
GB (1) GB1567671A (en)
NL (1) NL7709458A (en)
NO (2) NO147186C (en)
SE (2) SE432764B (en)
YU (1) YU41079B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
US4918219A (en) * 1983-10-31 1990-04-17 Warner-Lambert Company Glycerine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
YU45690B (en) * 1984-12-22 1992-07-20 Krka Tovarna Zdraviln.Sol.O. PROCEDURE FOR PREPARING 9- (2-HYDROXYETHOXYMETHYL) -GUANINE
DE3889248T2 (en) * 1987-05-04 1994-11-17 Kemijski Inst Process for the preparation of purine compounds.
EP0717744B1 (en) * 1993-09-10 1997-05-07 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY A process for the preparation of 9-(2-hydroxy)-ethoxymethyl-guanine
DE19536164A1 (en) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Improved Process for the Production of 9 - [(2-Hydroxyethoxy) methyl] guanine (Acyclovir)
IT1276126B1 (en) * 1995-11-14 1997-10-27 Archimica Spa PROCEDURE FOR THE PREPARATION OF 9 - ((2-HYDROXYETHOXY) METHYL) GUANINE
WO1997024357A1 (en) * 1995-12-28 1997-07-10 Mallinckrodt Chemical, Inc. Process for synthesis and purification of a compound useful in the preparation of acyclovir

Also Published As

Publication number Publication date
CA1096864A (en) 1981-03-03
SE447113B (en) 1986-10-27
SE7709606L (en) 1978-02-28
DK380377A (en) 1978-02-28
FI772548A (en) 1978-02-28
NO147186C (en) 1983-02-16
NO150119C (en) 1984-08-22
FI64160B (en) 1983-06-30
CS196384B2 (en) 1980-03-31
ATA620177A (en) 1979-12-15
YU202277A (en) 1983-02-28
CA1096863A (en) 1981-03-03
NL7709458A (en) 1978-03-01
YU41079B (en) 1986-12-31
NO150119B (en) 1984-05-14
CH634843A5 (en) 1983-02-28
SE432764B (en) 1984-04-16
FI64160C (en) 1983-10-10
DK147857C (en) 1985-06-10
NO772959L (en) 1978-02-28
DD131856A6 (en) 1978-07-26
SE8304549D0 (en) 1983-08-23
NO822502L (en) 1978-02-28
NO147186B (en) 1982-11-08
GB1567671A (en) 1980-05-21
AT357566B (en) 1980-07-25
DK147857B (en) 1984-12-24

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