SE8304549D0 - INTERMEDIATES FOR USE IN THE PROCEDURE FOR PURINES DERIVATIVES - Google Patents
INTERMEDIATES FOR USE IN THE PROCEDURE FOR PURINES DERIVATIVESInfo
- Publication number
- SE8304549D0 SE8304549D0 SE8304549A SE8304549A SE8304549D0 SE 8304549 D0 SE8304549 D0 SE 8304549D0 SE 8304549 A SE8304549 A SE 8304549A SE 8304549 A SE8304549 A SE 8304549A SE 8304549 D0 SE8304549 D0 SE 8304549D0
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- derivatives
- guanine
- intermediates
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
9-(2-Hydroxyethoxymethyl) derivatives of 2-amino-adenine and guanine of formula I are prepared by hydrolysis from compounds of formula II. The reaction is carried out in the presence of a base. The symbols in formula I and II have the meanings given in Patent Claim 1. The novel compounds of formula II are prepared by reacting the guanine or 2-aminoadenine, wherein the 2- and 9-positions, or the 2-, 6- and 9-positions, are acylated, with a diester of 2-oxa-1,4-butanediol. This reaction is carried out in the presence of a catalytic amount of an acid. The 9-(2-hydroxyethoxymethyl) derivatives of 2-aminoadenine and guanine are novel and exhibit an antiviral action, especially against the classes of the DNA- and RNA-viruses. <IMAGE>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71810576A | 1976-08-27 | 1976-08-27 | |
US05/773,135 US4146715A (en) | 1975-08-27 | 1977-02-28 | 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8304549L SE8304549L (en) | 1983-08-23 |
SE8304549D0 true SE8304549D0 (en) | 1983-08-23 |
SE447113B SE447113B (en) | 1986-10-27 |
Family
ID=27109837
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7709606A SE432764B (en) | 1976-08-27 | 1977-08-26 | PROCEDURE FOR PREPARING 2-AMINO-9- (2-HYDROXYETOXIMETHYL) ADENIN AND 9- (2-HYDROXYTOXYMETHYL) GUANINE |
SE8304549A SE447113B (en) | 1976-08-27 | 1983-08-23 | INTERMEDIATE PRODUCTS FOR THE PREPARATION OF 2-AMINO-9- (2-HYDROXYETHOXIMETHYL) ADENINE AND 9- (2-HYDROXYETHOXIMETHYL) -GUANIN |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7709606A SE432764B (en) | 1976-08-27 | 1977-08-26 | PROCEDURE FOR PREPARING 2-AMINO-9- (2-HYDROXYETOXIMETHYL) ADENIN AND 9- (2-HYDROXYTOXYMETHYL) GUANINE |
Country Status (12)
Country | Link |
---|---|
AT (1) | AT357566B (en) |
CA (2) | CA1096863A (en) |
CH (1) | CH634843A5 (en) |
CS (1) | CS196384B2 (en) |
DD (1) | DD131856A6 (en) |
DK (1) | DK147857C (en) |
FI (1) | FI64160C (en) |
GB (1) | GB1567671A (en) |
NL (1) | NL7709458A (en) |
NO (2) | NO147186C (en) |
SE (2) | SE432764B (en) |
YU (1) | YU41079B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4880820A (en) * | 1983-06-24 | 1989-11-14 | Merck & Co., Inc. | Guanine derivatives |
IE842642L (en) * | 1983-10-31 | 1985-04-30 | Harvard College | Purine Derivatives |
US4918219A (en) * | 1983-10-31 | 1990-04-17 | Warner-Lambert Company | Glycerine derivatives |
YU45690B (en) * | 1984-12-22 | 1992-07-20 | Krka Tovarna Zdraviln.Sol.O. | PROCEDURE FOR PREPARING 9- (2-HYDROXYETHOXYMETHYL) -GUANINE |
EP0564006A3 (en) * | 1987-05-04 | 1993-12-15 | Krka Tovarna Zdravil | Process for preparing purine derivatives and novel purine derivatives |
RU2125570C1 (en) * | 1993-09-10 | 1999-01-27 | Рекордати С.А.Кемикал Энд Фармасьютикал Компани | Method of synthesis of 9-(2-hydroxy)-ethoxymethylguanine |
DE19536164A1 (en) * | 1995-09-28 | 1997-04-03 | Boehringer Ingelheim Kg | Improved Process for the Production of 9 - [(2-Hydroxyethoxy) methyl] guanine (Acyclovir) |
IT1276126B1 (en) * | 1995-11-14 | 1997-10-27 | Archimica Spa | PROCEDURE FOR THE PREPARATION OF 9 - ((2-HYDROXYETHOXY) METHYL) GUANINE |
WO1997024357A1 (en) * | 1995-12-28 | 1997-07-10 | Mallinckrodt Chemical, Inc. | Process for synthesis and purification of a compound useful in the preparation of acyclovir |
-
1977
- 1977-08-24 YU YU2022/77A patent/YU41079B/en unknown
- 1977-08-26 DD DD7700200760A patent/DD131856A6/en not_active IP Right Cessation
- 1977-08-26 NL NL7709458A patent/NL7709458A/en active Search and Examination
- 1977-08-26 CS CS775615A patent/CS196384B2/en unknown
- 1977-08-26 GB GB35914/77A patent/GB1567671A/en not_active Expired
- 1977-08-26 CH CH1046677A patent/CH634843A5/en not_active IP Right Cessation
- 1977-08-26 CA CA285,592A patent/CA1096863A/en not_active Expired
- 1977-08-26 NO NO772959A patent/NO147186C/en unknown
- 1977-08-26 AT AT620177A patent/AT357566B/en not_active IP Right Cessation
- 1977-08-26 DK DK380377A patent/DK147857C/en not_active IP Right Cessation
- 1977-08-26 FI FI772548A patent/FI64160C/en not_active IP Right Cessation
- 1977-08-26 SE SE7709606A patent/SE432764B/en not_active IP Right Cessation
-
1980
- 1980-06-20 CA CA354,538A patent/CA1096864A/en not_active Expired
-
1982
- 1982-07-20 NO NO822502A patent/NO150119C/en unknown
-
1983
- 1983-08-23 SE SE8304549A patent/SE447113B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CS196384B2 (en) | 1980-03-31 |
YU41079B (en) | 1986-12-31 |
NO147186C (en) | 1983-02-16 |
DK147857B (en) | 1984-12-24 |
NO150119C (en) | 1984-08-22 |
DK380377A (en) | 1978-02-28 |
NO150119B (en) | 1984-05-14 |
CA1096863A (en) | 1981-03-03 |
YU202277A (en) | 1983-02-28 |
SE8304549L (en) | 1983-08-23 |
FI772548A (en) | 1978-02-28 |
DD131856A6 (en) | 1978-07-26 |
SE7709606L (en) | 1978-02-28 |
CA1096864A (en) | 1981-03-03 |
ATA620177A (en) | 1979-12-15 |
AT357566B (en) | 1980-07-25 |
SE432764B (en) | 1984-04-16 |
NO772959L (en) | 1978-02-28 |
GB1567671A (en) | 1980-05-21 |
FI64160B (en) | 1983-06-30 |
NL7709458A (en) | 1978-03-01 |
NO147186B (en) | 1982-11-08 |
SE447113B (en) | 1986-10-27 |
NO822502L (en) | 1978-02-28 |
CH634843A5 (en) | 1983-02-28 |
FI64160C (en) | 1983-10-10 |
DK147857C (en) | 1985-06-10 |
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