SE8300324L - DAUNORUBICIN AND DOXORUBICIN ANALOGS, THEIR PREPARATION AND USE - Google Patents

DAUNORUBICIN AND DOXORUBICIN ANALOGS, THEIR PREPARATION AND USE

Info

Publication number
SE8300324L
SE8300324L SE8300324A SE8300324A SE8300324L SE 8300324 L SE8300324 L SE 8300324L SE 8300324 A SE8300324 A SE 8300324A SE 8300324 A SE8300324 A SE 8300324A SE 8300324 L SE8300324 L SE 8300324L
Authority
SE
Sweden
Prior art keywords
daunorubicin
preparation
daunomycinone
och3
group
Prior art date
Application number
SE8300324A
Other languages
Swedish (sv)
Other versions
SE8300324D0 (en
SE461591B (en
Inventor
S Penco
G Franchi
F Arcamone
A M Casazza
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of SE8300324D0 publication Critical patent/SE8300324D0/en
Publication of SE8300324L publication Critical patent/SE8300324L/en
Publication of SE461591B publication Critical patent/SE461591B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

<IMAGE> The anthracycline glycosides I (X = H or OH, R1 = H or CH3, R2 = H or OCH3, R3 = H or OCH3, R2 = R3) and their pharmaceutically acceptable acid addition salts have antitumour properties. They are prepared from 4-demothoxy-daunomycinone or 2,3-dimethyl-4-methoxy-daunomycinone by condensation with an appropriate N-protected hexopyranosyl chloride and removal of the protecting group and, in the case X = OH, conversion of the 9-acetyl group to a 9-hydroxyacetyl group.
SE8300324A 1982-01-26 1983-01-21 DAUNORUBICIN AND DOXORUBICIN ANALOGS, THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM SE461591B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8202080 1982-01-26

Publications (3)

Publication Number Publication Date
SE8300324D0 SE8300324D0 (en) 1983-01-21
SE8300324L true SE8300324L (en) 1983-07-27
SE461591B SE461591B (en) 1990-03-05

Family

ID=10527864

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8300324A SE461591B (en) 1982-01-26 1983-01-21 DAUNORUBICIN AND DOXORUBICIN ANALOGS, THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM

Country Status (28)

Country Link
JP (1) JPS58128396A (en)
KR (1) KR900006214B1 (en)
AT (1) AT378776B (en)
AU (1) AU551700B2 (en)
BE (1) BE895687A (en)
CA (1) CA1197237A (en)
CH (1) CH657622A5 (en)
CS (1) CS235979B2 (en)
DE (1) DE3301489A1 (en)
DK (1) DK157322C (en)
ES (1) ES519255A0 (en)
FI (1) FI74977C (en)
FR (1) FR2520365B1 (en)
GB (1) GB2116169B (en)
GR (1) GR77890B (en)
HU (1) HU192784B (en)
IE (1) IE53750B1 (en)
IL (1) IL67709A (en)
IT (1) IT1210482B (en)
NL (1) NL8300150A (en)
NO (1) NO153456C (en)
NZ (1) NZ203047A (en)
PH (1) PH19130A (en)
PT (1) PT76113A (en)
SE (1) SE461591B (en)
SU (1) SU1187724A3 (en)
YU (1) YU43536B (en)
ZA (1) ZA83450B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2182926B (en) * 1985-11-19 1989-10-04 Erba Farmitalia Nitro anthracyclines, process for their preparation and use thereof
GB8708927D0 (en) * 1987-04-14 1987-05-20 Erba Farmitalia Chiral synthesis of anthracyclines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
GB1573037A (en) * 1977-05-05 1980-08-13 Farmaceutici Italia Anthracyclines
EP0022515B1 (en) * 1979-07-04 1983-08-03 FARMITALIA CARLO ERBA S.p.A. Anthracycline glycosides, process for their preparation and therapeutical composition containing them
DE3100968A1 (en) * 1980-01-16 1982-01-14 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracycline derivatives, a process for their preparation and pharmaceuticals containing these compounds

Also Published As

Publication number Publication date
GB2116169A (en) 1983-09-21
BE895687A (en) 1983-05-16
AU551700B2 (en) 1986-05-08
SE8300324D0 (en) 1983-01-21
KR840003262A (en) 1984-08-20
DK157322C (en) 1990-05-07
CS235979B2 (en) 1985-05-15
JPS58128396A (en) 1983-07-30
JPS6328436B2 (en) 1988-06-08
GR77890B (en) 1984-09-25
DE3301489A1 (en) 1983-08-04
PH19130A (en) 1986-01-08
AT378776B (en) 1985-09-25
FI74977C (en) 1988-04-11
ATA15683A (en) 1985-02-15
IE830144L (en) 1983-07-26
NO153456B (en) 1985-12-16
PT76113A (en) 1983-02-01
NZ203047A (en) 1985-10-11
DK157322B (en) 1989-12-11
ZA83450B (en) 1983-10-26
SE461591B (en) 1990-03-05
YU43536B (en) 1989-08-31
NO830234L (en) 1983-07-27
DK27683D0 (en) 1983-01-25
NO153456C (en) 1986-03-26
AU1052583A (en) 1983-08-04
CH657622A5 (en) 1986-09-15
KR900006214B1 (en) 1990-08-25
FI74977B (en) 1987-12-31
NL8300150A (en) 1983-08-16
DK27683A (en) 1983-07-27
ES8403140A1 (en) 1984-03-01
FI830155L (en) 1983-07-27
FI830155A0 (en) 1983-01-17
IE53750B1 (en) 1989-02-01
IL67709A0 (en) 1983-05-15
GB2116169B (en) 1985-09-04
CA1197237A (en) 1985-11-26
IL67709A (en) 1986-03-31
DE3301489C2 (en) 1988-01-28
IT1210482B (en) 1989-09-14
SU1187724A3 (en) 1985-10-23
HU192784B (en) 1987-07-28
ES519255A0 (en) 1984-03-01
FR2520365B1 (en) 1985-07-12
FR2520365A1 (en) 1983-07-29
YU8983A (en) 1986-02-28
IT8319147A0 (en) 1983-01-18
GB8301178D0 (en) 1983-02-16

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