SE8207194L - ESTERS OF 4-HYDROXIMETHYL-1-PHTALAZON DERIVATIVES AND SALTS THEREOF - Google Patents

ESTERS OF 4-HYDROXIMETHYL-1-PHTALAZON DERIVATIVES AND SALTS THEREOF

Info

Publication number
SE8207194L
SE8207194L SE8207194A SE8207194A SE8207194L SE 8207194 L SE8207194 L SE 8207194L SE 8207194 A SE8207194 A SE 8207194A SE 8207194 A SE8207194 A SE 8207194A SE 8207194 L SE8207194 L SE 8207194L
Authority
SE
Sweden
Prior art keywords
image
amine
substituted
hydrogen
esters
Prior art date
Application number
SE8207194A
Other languages
Swedish (sv)
Other versions
SE8207194D0 (en
Inventor
M Ishikawa
S Itoh
J Yoshizawa
H Takezawa
M Ihara
R Nishizawa
H Sugimura
M Yoshida
Original Assignee
Nippon Kayaku Kk
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Kk, Banyu Pharma Co Ltd filed Critical Nippon Kayaku Kk
Publication of SE8207194D0 publication Critical patent/SE8207194D0/en
Publication of SE8207194L publication Critical patent/SE8207194L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esters of 4-hydroxymethyl-1- phthalazones useful for treating cerebral apoplexy, cerebral thrombosis and atherosclerosis are compounds having the general formula <IMAGE> wherein R1 is a C1-C6 alkyl group and R2 is -SO3H, <IMAGE> wherein R3 is hydrogen, alkyl, aryl or aralkyl, or <IMAGE> wherein W is a group formed by removal of a hydrogen atom from a ring of a cyclic imine of 4 or 5 carbon atoms which may be substituted by hydroxyl or a residual group represented by the formula <IMAGE> wherein X is a residual group which may be substituted formed by removal of 3 hydrogen atoms from an alkane, alkene, cycloalkane or aromatic hydrocarbon of 6 to 12 carbon atoms; one of Y and Z is hydrogen or carboxyl, amine or substituted amine and the other is carboxyl, amine or substituted amine; or are physiologically acceptable salts thereof.
SE8207194A 1981-12-29 1982-12-16 ESTERS OF 4-HYDROXIMETHYL-1-PHTALAZON DERIVATIVES AND SALTS THEREOF SE8207194L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56210448A JPS58116471A (en) 1981-12-29 1981-12-29 4-hydroxymethyl-1-phthalazone ester derivative and its ester

Publications (2)

Publication Number Publication Date
SE8207194D0 SE8207194D0 (en) 1982-12-16
SE8207194L true SE8207194L (en) 1983-06-30

Family

ID=16589493

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8207194A SE8207194L (en) 1981-12-29 1982-12-16 ESTERS OF 4-HYDROXIMETHYL-1-PHTALAZON DERIVATIVES AND SALTS THEREOF

Country Status (10)

Country Link
JP (1) JPS58116471A (en)
BE (1) BE895500A (en)
DE (1) DE3248431A1 (en)
DK (1) DK572782A (en)
ES (1) ES519091A0 (en)
FR (1) FR2518991A1 (en)
GB (1) GB2112389A (en)
IT (1) IT8225026A0 (en)
NL (1) NL8205038A (en)
SE (1) SE8207194L (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2127805A (en) * 1982-09-13 1984-04-18 Showa Denko Kk Phthalazones
EP1070056B1 (en) * 1998-03-14 2004-06-30 ALTANA Pharma AG Phthalazinone pde iii/iv inhibitors
DE19921567A1 (en) 1999-05-11 2000-11-16 Basf Ag Use of phthalazine derivatives
CA2376202C (en) 1999-06-07 2008-11-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel preparation and administration form comprising an acid-labile active compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205004A1 (en) * 1973-10-30 1976-03-31 Ishikawa M PROCEDURE TO PREPARE 6,8-DIALKYL-7-ALCOXY-CARBONYL-4-HYDROXIMETHYL-1-PHTHALAZONE AND 7,8-LACTONE DERIVATIVES

Also Published As

Publication number Publication date
NL8205038A (en) 1983-07-18
DK572782A (en) 1983-06-30
BE895500A (en) 1983-04-15
ES8404786A1 (en) 1984-05-16
GB2112389A (en) 1983-07-20
DE3248431A1 (en) 1983-07-14
FR2518991A1 (en) 1983-07-01
ES519091A0 (en) 1984-05-16
JPS58116471A (en) 1983-07-11
IT8225026A0 (en) 1982-12-29
SE8207194D0 (en) 1982-12-16

Similar Documents

Publication Publication Date Title
LU91587I2 (en) Agomelatine and its pharmaceutically acceptable derivatives (VALDOXAN)
DE68923250D1 (en) Chalcone derivatives and process for their preparation.
BR9612099A (en) Process for preparing a compound derived from piperidine, regioisomer, process for preparing a regioisomer, derived from 4- (alpha, alpha, di-substituted) toluic acid and 4- (alpha, alpha-di-unsubstituted) toluic acid.
PT99135A (en) PROCESS FOR THE PREPARATION OF PIPERAZINE DERIVATIVES
PT99134A (en) PROCESS FOR THE PREPARATION OF PIPERAZINE DERIVATIVES
FI73992B (en) FOERFARANDE FOER FRAMSTAELLNING AV 4- (3-TRIFLUORMETHYLPHENYL-1,2,3,6-TETRAHYDROPYRIDINER, VILKA HAR ANOREKTISK AKTIVITET.
SE7605361L (en) WAY TO PREPARE NEW N-SUBSTITUTED PHENYL PIPERAZINE DERIVATIVES
SE8207194L (en) ESTERS OF 4-HYDROXIMETHYL-1-PHTALAZON DERIVATIVES AND SALTS THEREOF
ATE671T1 (en) PROCESS FOR DISSOLVING ORGANIC OR MINERAL SALTS IN ORGANIC SOLVENTS AND COMPLEX ORGANIC OR MINERAL SALTS.
FI913067A0 (en) BISFOSFONSYRADERIVAT, DERAS FRAMSTAELLNING OCH ANVAENDNING.
ATE214070T1 (en) GALANTHAMIN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
DK0600950T3 (en) Tetrazolamides as Inhibitors of ACAT
ES2148587T3 (en) PRODUCTION PROCEDURE OF 2- (2-HYDROXYMETHYLPHENYL) ACETAMIDE DERIVATIVE AND INTERMEDIARY USED FOR ITS PRODUCTION.
NO821693L (en) PROCEDURE FOR MANUFACTURE OF NEW CARBACYCLINES.
NO171362C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF NEW ARALKYLAMINE COMPOUNDS AND THEIR SALTS
UA43338C2 (en) Benzene derivatives
ATE3111T1 (en) PROCESS FOR THE PREPARATION OF PHENYL-PROPYLMORPHOLINE AND PIPERIDINE DERIVATIVES.
GB2017087A (en) Process for the preparation of xanthone derivatives
ATE6500T1 (en) 2-ALPHA-METHYL-DOPAMINIMINO-6,7-DIHYDROXY-1,2,3-4-TETRAHYDRONAPHTHALINE, ITS SALTS, AND PROCESS FOR THE PRODUCTION THEREOF.
GB2004885A (en) Indolopyrones
GB1445668A (en) Process for obtaining the optical isomers of penicillamine
HUT55786A (en) New 1-oxa-2-oxo-8-aza-spiro (4,5) decane derivatives and process for producing them
FI924944A0 (en) ETT FOERFARANDE FOER FRAMSTAELLNING AV AMINOALKANFOSFONSYROR, -SALTER OCH / ELLER -ESTRAR
ES451918A1 (en) Substituted 2-(2-hydroxyethyl)tetrahydro-1,4 oxazines and quaternary salts thereof useful for treating spasmodic syndromes
SE7901707L (en) 2-BETOXYBENZAMIDES

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8207194-5

Format of ref document f/p: F