SE8205870L - NEW PRODUCTS 3-AMINO-2-OXO-AZETIDINE-1-SULPHONIC ACID DERIVATIVES, SET FOR MANUFACTURING THEREOF, USING IT AS A MEDICINAL PRODUCT, COMPOSITIONS CONTAINING THEM AND RECEIVING NEW INTERMEDIATE PRODUCTS - Google Patents

NEW PRODUCTS 3-AMINO-2-OXO-AZETIDINE-1-SULPHONIC ACID DERIVATIVES, SET FOR MANUFACTURING THEREOF, USING IT AS A MEDICINAL PRODUCT, COMPOSITIONS CONTAINING THEM AND RECEIVING NEW INTERMEDIATE PRODUCTS

Info

Publication number
SE8205870L
SE8205870L SE8205870A SE8205870A SE8205870L SE 8205870 L SE8205870 L SE 8205870L SE 8205870 A SE8205870 A SE 8205870A SE 8205870 A SE8205870 A SE 8205870A SE 8205870 L SE8205870 L SE 8205870L
Authority
SE
Sweden
Prior art keywords
radical
azetidine
hydrogen atom
products
compound
Prior art date
Application number
SE8205870A
Other languages
Swedish (sv)
Other versions
SE8205870D0 (en
SE461655B (en
Inventor
R Heymes
A Bonnet
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE8205870D0 publication Critical patent/SE8205870D0/en
Publication of SE8205870L publication Critical patent/SE8205870L/en
Publication of SE461655B publication Critical patent/SE461655B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

An azetidine of formula (I): <IMAGE> or a salt thereof, in which R represents a hydrogen atom or a linear or branched, alkyl, alkenyl, or alkynyl radical having at most 12 carbon atoms, which radical is optionally substituted; R1 represents a radical -(CH2)n-X; in which n represents an integer from 1 to 4; and X represents a halogen atom; a cyano radical; a radical O-R'1 in which R'1 represents a hydrogen atom or an alkyl radical; or X represents a radical S-R''1 in which R''1 represents a hydrogen atom, an alkyl radical or a heterocyclic radical; or X represents a radical <IMAGE> in which R' and R'' are the same or different and each represents a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms, or R' and R'' together with the nitrogen atom to which they are attached form a heterocyclic radical; or X represents an azido, a thiocyanato or an isothiocyanato radical; and the wavy line indicates that the compound is in its cis or transform or in the form of a cis-trans mixture; the oxime group in the compound being in the syn form, and the compound being in the racemic or an optically active form, is a new compound. The azetidine and its pharmaceutically acceptable salts are medicaments particularly antibiotics.
SE8205870A 1981-10-23 1982-10-15 3-AMINO-2-OXO-AZETIDIN-1-SULPHONIC ACID DERIVATIVES, PREPARED FOR PREPARATION THEREOF, AND THESE DERIVATIVES FOR USE AS A MEDICINE SE461655B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8119946A FR2515182B1 (en) 1981-10-23 1981-10-23 NOVEL PRODUCTS DERIVED FROM 3-AMINO 2-OXO AZETIDINE 1-SULFAMIC ACID, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION

Publications (3)

Publication Number Publication Date
SE8205870D0 SE8205870D0 (en) 1982-10-15
SE8205870L true SE8205870L (en) 1983-04-24
SE461655B SE461655B (en) 1990-03-12

Family

ID=9263337

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8205870A SE461655B (en) 1981-10-23 1982-10-15 3-AMINO-2-OXO-AZETIDIN-1-SULPHONIC ACID DERIVATIVES, PREPARED FOR PREPARATION THEREOF, AND THESE DERIVATIVES FOR USE AS A MEDICINE
SE8702330A SE500849C2 (en) 1981-10-23 1987-06-04 New 3-amino-2-oxo-azetidine-1-sulfonic acids, intermediates to the corresponding 3-amino-substituted-2-oxo-azetidine-1-sulfonic acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8702330A SE500849C2 (en) 1981-10-23 1987-06-04 New 3-amino-2-oxo-azetidine-1-sulfonic acids, intermediates to the corresponding 3-amino-substituted-2-oxo-azetidine-1-sulfonic acids

Country Status (12)

Country Link
JP (2) JPS58135883A (en)
AT (1) AT382150B (en)
BE (1) BE894785A (en)
CA (1) CA1201439A (en)
CH (1) CH655317A5 (en)
DE (1) DE3239157C2 (en)
FR (1) FR2515182B1 (en)
GB (1) GB2111482B (en)
IT (1) IT1157233B (en)
LU (1) LU84434A1 (en)
NL (1) NL8204089A (en)
SE (2) SE461655B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
MX7096E (en) * 1980-12-05 1987-06-19 Takeda Chemical Industries Ltd METHOD FOR PREPARATION OF 2-OXOAZETIDINE DERIVATIVES
US4675397A (en) * 1980-12-05 1987-06-23 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
US4673739A (en) * 1980-12-05 1987-06-16 Takeda Chemical Industries, Ltd. 4-carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
US4572801A (en) * 1981-04-30 1986-02-25 Takeda Chemical Industries, Ltd. 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production
FR2558467B2 (en) * 1981-10-23 1987-03-20 Roussel Uclaf NEW PRODUCT DERIVED FROM 3-AMINO 2-OXO AZETIDINE 1-SULPHAMIC ACID, ITS PREPARATION PROCESS, ITS USE AS A MEDICAMENT AND AN INTERMEDIATE PRODUCT NECESSARY FOR ITS PREPARATION
US4443374A (en) * 1982-02-01 1984-04-17 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
JPS58208288A (en) * 1982-05-31 1983-12-03 Banyu Pharmaceut Co Ltd 2-oxo-1-azetidinesulfonic acid derivative
JPS59175490A (en) * 1983-03-24 1984-10-04 Banyu Pharmaceut Co Ltd 2-oxo-1-azetidinesulfonic acid derivative
EP0096296B1 (en) * 1982-06-03 1987-07-29 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 1-sulfo-2-oxoazetidine derivatives
DE3377061D1 (en) * 1982-06-03 1988-07-21 Hoffmann La Roche Process for the preparation of 1-sulfo-2-oxoazetidine derivatives
JPS5982359A (en) * 1982-11-02 1984-05-12 Kanegafuchi Chem Ind Co Ltd Preparation of 4(r) coordinated optically active beta-lactam compound
EP0117053A1 (en) * 1983-02-10 1984-08-29 Ajinomoto Co., Inc. Azetidinone derivatives
JPS59231086A (en) * 1983-06-15 1984-12-25 Teikoku Hormone Mfg Co Ltd 4-methoxyethyl-2-azetidinone-1-sulfonic acid derivative
US4501697A (en) * 1983-06-17 1985-02-26 E. R. Squibb & Sons, Inc. 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts
JPS6097978A (en) * 1983-10-31 1985-05-31 Otsuka Chem Co Ltd 3-acylamino-4-methyl-2-azetidinone-1-sulfonic acid derivative, its production and drug containing said derivative
JPS60202882A (en) * 1984-03-27 1985-10-14 Teikoku Hormone Mfg Co Ltd Novel 2-azetidinone-1-sulfonic acid derivative
WO1986006722A1 (en) * 1985-05-09 1986-11-20 The Upjohn Company Carbonate substituted monobactams as antibiotics
US4837318A (en) * 1985-05-09 1989-06-06 The Upjohn Company Carbonate substituted monobactams as antibiotics
DE19642530A1 (en) * 1996-10-15 1998-04-16 Bayer Ag Haloalkoximinoacetic acid amides
US6677028B1 (en) 1999-09-10 2004-01-13 3M Innovative Properties Company Retroreflective articles having multilayer films and methods of manufacturing same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166816A (en) * 1975-05-05 1979-09-04 Smithkline Corporation Methods and intermediates for preparing cis-4-oxoazetidine intermediates
DK194776A (en) * 1975-05-05 1976-11-06 Smithkline Corp ANTIBACTERIAL MEDICINES AND INTERMEDIATE PRODUCTS THEREOF
FR2361885A1 (en) * 1975-09-03 1978-03-17 Smithkline Corp ANALOGUES OF PENICILLIN, THEIR INTERMEDIARIES AND METHODS FOR OBTAINING THEM
US4085100A (en) * 1976-11-01 1978-04-18 Smithkline Corporation Intermediate for dephthaloylation of azetidinone compounds
US4144333A (en) * 1976-11-15 1979-03-13 Smithkline Corporation Monocyclic beta-lactams with antibacterial activity
EP0005507A1 (en) * 1978-05-18 1979-11-28 Ciba-Geigy Ag Process for the fragmentation of 3-(2-hydroxyimino-acetylamino)-2-oxo azetidin compounds and compounds obtained thereby
EP0021678B1 (en) * 1979-06-08 1984-11-07 Takeda Chemical Industries, Ltd. 1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof
NZ196202A (en) * 1980-02-07 1984-07-31 Squibb & Sons Inc Beta-lactam antibiotics (of azetidine-sulphonic acid type)
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
JPS57131758A (en) * 1980-12-05 1982-08-14 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use
JPS58189176A (en) 1982-04-30 1983-11-04 Takeda Chem Ind Ltd 1-sulfo-2-azetidinone derivative and its preparation
JPS58210061A (en) 1982-05-31 1983-12-07 Takeda Chem Ind Ltd 1-sulfo-2-oxoazetidine derivative, its preparation and use
ATE24726T1 (en) * 1981-10-05 1987-01-15 Squibb & Sons Inc 4-AETHER DERIVATIVES OF 2-AZETIDINONE-1-SULFONIC ACIDS.
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
JPS59175490A (en) * 1983-03-24 1984-10-04 Banyu Pharmaceut Co Ltd 2-oxo-1-azetidinesulfonic acid derivative
HU189290B (en) * 1982-05-31 1986-06-30 Banyu Pharmaceutical Co Ltd,Jp Process for preparing new 2-oxo-1-azetidine-sulphonic acid derivatives and pharmaceutically acceptable salts thereof, further pharmaceutical compositions containing such derivatives as active substances
JPS58208288A (en) * 1982-05-31 1983-12-03 Banyu Pharmaceut Co Ltd 2-oxo-1-azetidinesulfonic acid derivative

Also Published As

Publication number Publication date
JPH04234844A (en) 1992-08-24
FR2515182B1 (en) 1986-05-09
IT1157233B (en) 1987-02-11
GB2111482B (en) 1985-11-06
AT382150B (en) 1987-01-12
GB2111482A (en) 1983-07-06
SE8702330L (en) 1987-06-04
SE8702330D0 (en) 1987-06-04
SE500849C2 (en) 1994-09-19
BE894785A (en) 1983-04-22
DE3239157C2 (en) 1994-04-28
CH655317A5 (en) 1986-04-15
DE3239157A1 (en) 1983-05-05
JPS58135883A (en) 1983-08-12
CA1201439A (en) 1986-03-04
NL8204089A (en) 1983-05-16
FR2515182A1 (en) 1983-04-29
SE8205870D0 (en) 1982-10-15
IT8249341A0 (en) 1982-10-22
JPH0730018B2 (en) 1995-04-05
SE461655B (en) 1990-03-12
LU84434A1 (en) 1983-06-13
JPH0471073B2 (en) 1992-11-12
ATA391182A (en) 1986-06-15

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