SE8205870D0 - NOUVEAUX PRODUITS DERIVES DE LḖACIDE 3-AMINO 2-OXO AZETIDINE 1-SULFAMIDE, LEUR PREPARATION, LEUR APPLICATION COMME MEDICAMENTS, LES COMPOSITIONS LES RENFERMANT ET LES PRODUITS INTERMEDIAIRES NOUVEAUX OBTENUS - Google Patents
NOUVEAUX PRODUITS DERIVES DE LḖACIDE 3-AMINO 2-OXO AZETIDINE 1-SULFAMIDE, LEUR PREPARATION, LEUR APPLICATION COMME MEDICAMENTS, LES COMPOSITIONS LES RENFERMANT ET LES PRODUITS INTERMEDIAIRES NOUVEAUX OBTENUSInfo
- Publication number
- SE8205870D0 SE8205870D0 SE8205870A SE8205870A SE8205870D0 SE 8205870 D0 SE8205870 D0 SE 8205870D0 SE 8205870 A SE8205870 A SE 8205870A SE 8205870 A SE8205870 A SE 8205870A SE 8205870 D0 SE8205870 D0 SE 8205870D0
- Authority
- SE
- Sweden
- Prior art keywords
- radical
- les
- nouveaux
- produits
- leur
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- GCBWDZYSLVSRRI-UHFFFAOYSA-N 3-aminoazetidin-2-one Chemical compound NC1CNC1=O GCBWDZYSLVSRRI-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- NYAZXHASVIWIRJ-UHFFFAOYSA-N nitridosulfidocarbon(.) Chemical compound [S]C#N NYAZXHASVIWIRJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003544 oxime group Chemical group 0.000 abstract 1
- 125000000858 thiocyanato group Chemical group *SC#N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
An azetidine of formula (I): <IMAGE> or a salt thereof, in which R represents a hydrogen atom or a linear or branched, alkyl, alkenyl, or alkynyl radical having at most 12 carbon atoms, which radical is optionally substituted; R1 represents a radical -(CH2)n-X; in which n represents an integer from 1 to 4; and X represents a halogen atom; a cyano radical; a radical O-R'1 in which R'1 represents a hydrogen atom or an alkyl radical; or X represents a radical S-R''1 in which R''1 represents a hydrogen atom, an alkyl radical or a heterocyclic radical; or X represents a radical <IMAGE> in which R' and R'' are the same or different and each represents a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms, or R' and R'' together with the nitrogen atom to which they are attached form a heterocyclic radical; or X represents an azido, a thiocyanato or an isothiocyanato radical; and the wavy line indicates that the compound is in its cis or transform or in the form of a cis-trans mixture; the oxime group in the compound being in the syn form, and the compound being in the racemic or an optically active form, is a new compound. The azetidine and its pharmaceutically acceptable salts are medicaments particularly antibiotics.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8119946A FR2515182B1 (en) | 1981-10-23 | 1981-10-23 | NOVEL PRODUCTS DERIVED FROM 3-AMINO 2-OXO AZETIDINE 1-SULFAMIC ACID, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8205870D0 true SE8205870D0 (en) | 1982-10-15 |
| SE8205870L SE8205870L (en) | 1983-04-24 |
| SE461655B SE461655B (en) | 1990-03-12 |
Family
ID=9263337
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8205870A SE461655B (en) | 1981-10-23 | 1982-10-15 | 3-AMINO-2-OXO-AZETIDIN-1-SULPHONIC ACID DERIVATIVES, PREPARED FOR PREPARATION THEREOF, AND THESE DERIVATIVES FOR USE AS A MEDICINE |
| SE8702330A SE500849C2 (en) | 1981-10-23 | 1987-06-04 | New 3-amino-2-oxo-azetidine-1-sulfonic acids, intermediates to the corresponding 3-amino-substituted-2-oxo-azetidine-1-sulfonic acids |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8702330A SE500849C2 (en) | 1981-10-23 | 1987-06-04 | New 3-amino-2-oxo-azetidine-1-sulfonic acids, intermediates to the corresponding 3-amino-substituted-2-oxo-azetidine-1-sulfonic acids |
Country Status (12)
| Country | Link |
|---|---|
| JP (2) | JPS58135883A (en) |
| AT (1) | AT382150B (en) |
| BE (1) | BE894785A (en) |
| CA (1) | CA1201439A (en) |
| CH (1) | CH655317A5 (en) |
| DE (1) | DE3239157C2 (en) |
| FR (1) | FR2515182B1 (en) |
| GB (1) | GB2111482B (en) |
| IT (1) | IT1157233B (en) |
| LU (1) | LU84434A1 (en) |
| NL (1) | NL8204089A (en) |
| SE (2) | SE461655B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982001873A1 (en) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | 1-sulfo-2-oxoazetidine derivatives and process for their preparation |
| MX7096E (en) * | 1980-12-05 | 1987-06-19 | Takeda Chemical Industries Ltd | METHOD FOR PREPARATION OF 2-OXOAZETIDINE DERIVATIVES |
| US4675397A (en) * | 1980-12-05 | 1987-06-23 | Takeda Chemical Industries, Ltd. | 1-sulfo-2-oxoazetidine derivatives and their production |
| US4673739A (en) * | 1980-12-05 | 1987-06-16 | Takeda Chemical Industries, Ltd. | 4-carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production |
| US4572801A (en) * | 1981-04-30 | 1986-02-25 | Takeda Chemical Industries, Ltd. | 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production |
| FR2558467B2 (en) * | 1981-10-23 | 1987-03-20 | Roussel Uclaf | NEW PRODUCT DERIVED FROM 3-AMINO 2-OXO AZETIDINE 1-SULPHAMIC ACID, ITS PREPARATION PROCESS, ITS USE AS A MEDICAMENT AND AN INTERMEDIATE PRODUCT NECESSARY FOR ITS PREPARATION |
| US4443374A (en) * | 1982-02-01 | 1984-04-17 | E. R. Squibb & Sons, Inc. | Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives |
| JPS58208288A (en) * | 1982-05-31 | 1983-12-03 | Banyu Pharmaceut Co Ltd | 2-oxo-1-azetidinesulfonic acid derivative |
| JPS59175490A (en) * | 1983-03-24 | 1984-10-04 | Banyu Pharmaceut Co Ltd | 2-oxo-1-azetidinesulfonic acid derivative |
| EP0096296B1 (en) * | 1982-06-03 | 1987-07-29 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 1-sulfo-2-oxoazetidine derivatives |
| DE3377061D1 (en) * | 1982-06-03 | 1988-07-21 | Hoffmann La Roche | Process for the preparation of 1-sulfo-2-oxoazetidine derivatives |
| JPS5982359A (en) * | 1982-11-02 | 1984-05-12 | Kanegafuchi Chem Ind Co Ltd | Preparation of 4(r) coordinated optically active beta-lactam compound |
| EP0117053A1 (en) * | 1983-02-10 | 1984-08-29 | Ajinomoto Co., Inc. | Azetidinone derivatives |
| JPS59231086A (en) * | 1983-06-15 | 1984-12-25 | Teikoku Hormone Mfg Co Ltd | 4-methoxyethyl-2-azetidinone-1-sulfonic acid derivative |
| US4501697A (en) * | 1983-06-17 | 1985-02-26 | E. R. Squibb & Sons, Inc. | 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts |
| JPS6097978A (en) * | 1983-10-31 | 1985-05-31 | Otsuka Chem Co Ltd | 3-acylamino-4-methyl-2-azetidinone-1-sulfonic acid derivative, its production and drug containing said derivative |
| JPS60202882A (en) * | 1984-03-27 | 1985-10-14 | Teikoku Hormone Mfg Co Ltd | Novel 2-azetidinone-1-sulfonic acid derivative |
| US4837318A (en) * | 1985-05-09 | 1989-06-06 | The Upjohn Company | Carbonate substituted monobactams as antibiotics |
| JPS62502825A (en) * | 1985-05-09 | 1987-11-12 | ジ・アップジョン・カンパニ− | Carbonate-substituted monobactams as antibiotics |
| DE19642530A1 (en) * | 1996-10-15 | 1998-04-16 | Bayer Ag | Haloalkoximinoacetic acid amides |
| US6677028B1 (en) | 1999-09-10 | 2004-01-13 | 3M Innovative Properties Company | Retroreflective articles having multilayer films and methods of manufacturing same |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK194776A (en) * | 1975-05-05 | 1976-11-06 | Smithkline Corp | ANTIBACTERIAL MEDICINES AND INTERMEDIATE PRODUCTS THEREOF |
| US4166816A (en) * | 1975-05-05 | 1979-09-04 | Smithkline Corporation | Methods and intermediates for preparing cis-4-oxoazetidine intermediates |
| FR2361885A1 (en) * | 1975-09-03 | 1978-03-17 | Smithkline Corp | ANALOGUES OF PENICILLIN, THEIR INTERMEDIARIES AND METHODS FOR OBTAINING THEM |
| US4085100A (en) * | 1976-11-01 | 1978-04-18 | Smithkline Corporation | Intermediate for dephthaloylation of azetidinone compounds |
| US4144333A (en) * | 1976-11-15 | 1979-03-13 | Smithkline Corporation | Monocyclic beta-lactams with antibacterial activity |
| EP0005507A1 (en) * | 1978-05-18 | 1979-11-28 | Ciba-Geigy Ag | Process for the fragmentation of 3-(2-hydroxyimino-acetylamino)-2-oxo azetidin compounds and compounds obtained thereby |
| EP0021678B1 (en) * | 1979-06-08 | 1984-11-07 | Takeda Chemical Industries, Ltd. | 1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof |
| NZ196202A (en) * | 1980-02-07 | 1984-07-31 | Squibb & Sons Inc | Beta-lactam antibiotics (of azetidine-sulphonic acid type) |
| WO1982001873A1 (en) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | 1-sulfo-2-oxoazetidine derivatives and process for their preparation |
| JPS57131758A (en) * | 1980-12-05 | 1982-08-14 | Takeda Chem Ind Ltd | 1-sulfo-2-oxoazetidine derivative, its preparation and use |
| JPS58210061A (en) | 1982-05-31 | 1983-12-07 | Takeda Chem Ind Ltd | 1-sulfo-2-oxoazetidine derivative, its preparation and use |
| JPS58189176A (en) | 1982-04-30 | 1983-11-04 | Takeda Chem Ind Ltd | 1-sulfo-2-azetidinone derivative and its preparation |
| EP0076758B1 (en) * | 1981-10-05 | 1987-01-07 | E.R. Squibb & Sons, Inc. | 4-ether derivatives of 2-azetidinone-1-sulfonic acids |
| AU564150B2 (en) * | 1982-04-30 | 1987-08-06 | Takeda Chemical Industries Ltd. | 1-sulfo-2-azetidinone derivatives |
| JPS59175490A (en) * | 1983-03-24 | 1984-10-04 | Banyu Pharmaceut Co Ltd | 2-oxo-1-azetidinesulfonic acid derivative |
| SU1195908A3 (en) * | 1982-05-31 | 1985-11-30 | Баниу Фармасьютикал Ко.,Лтд.(Фирма) | Method of producing 2-oxo-1-azetidinesulfoacid derivatives or their salts with alkali metals |
| JPS58208288A (en) * | 1982-05-31 | 1983-12-03 | Banyu Pharmaceut Co Ltd | 2-oxo-1-azetidinesulfonic acid derivative |
-
1981
- 1981-10-23 FR FR8119946A patent/FR2515182B1/en not_active Expired
-
1982
- 1982-10-15 SE SE8205870A patent/SE461655B/en not_active IP Right Cessation
- 1982-10-22 LU LU84434A patent/LU84434A1/en unknown
- 1982-10-22 CH CH6166/82A patent/CH655317A5/en not_active IP Right Cessation
- 1982-10-22 JP JP57184814A patent/JPS58135883A/en active Granted
- 1982-10-22 IT IT49341/82A patent/IT1157233B/en active
- 1982-10-22 CA CA000413983A patent/CA1201439A/en not_active Expired
- 1982-10-22 NL NL8204089A patent/NL8204089A/en not_active Application Discontinuation
- 1982-10-22 BE BE0/209311A patent/BE894785A/en not_active IP Right Cessation
- 1982-10-22 DE DE3239157A patent/DE3239157C2/en not_active Expired - Fee Related
- 1982-10-25 GB GB08230366A patent/GB2111482B/en not_active Expired
- 1982-10-25 AT AT0391182A patent/AT382150B/en not_active IP Right Cessation
-
1987
- 1987-06-04 SE SE8702330A patent/SE500849C2/en unknown
-
1991
- 1991-04-26 JP JP3122828A patent/JPH0730018B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IT1157233B (en) | 1987-02-11 |
| JPH04234844A (en) | 1992-08-24 |
| GB2111482A (en) | 1983-07-06 |
| SE8702330D0 (en) | 1987-06-04 |
| JPS58135883A (en) | 1983-08-12 |
| LU84434A1 (en) | 1983-06-13 |
| SE8205870L (en) | 1983-04-24 |
| CA1201439A (en) | 1986-03-04 |
| SE8702330L (en) | 1987-06-04 |
| IT8249341A0 (en) | 1982-10-22 |
| SE500849C2 (en) | 1994-09-19 |
| FR2515182A1 (en) | 1983-04-29 |
| CH655317A5 (en) | 1986-04-15 |
| DE3239157C2 (en) | 1994-04-28 |
| JPH0471073B2 (en) | 1992-11-12 |
| GB2111482B (en) | 1985-11-06 |
| FR2515182B1 (en) | 1986-05-09 |
| ATA391182A (en) | 1986-06-15 |
| BE894785A (en) | 1983-04-22 |
| NL8204089A (en) | 1983-05-16 |
| SE461655B (en) | 1990-03-12 |
| DE3239157A1 (en) | 1983-05-05 |
| AT382150B (en) | 1987-01-12 |
| JPH0730018B2 (en) | 1995-04-05 |
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