SE8203887D0 - Nya trombininhiberande foreningar - Google Patents
Nya trombininhiberande foreningarInfo
- Publication number
- SE8203887D0 SE8203887D0 SE8203887A SE8203887A SE8203887D0 SE 8203887 D0 SE8203887 D0 SE 8203887D0 SE 8203887 A SE8203887 A SE 8203887A SE 8203887 A SE8203887 A SE 8203887A SE 8203887 D0 SE8203887 D0 SE 8203887D0
- Authority
- SE
- Sweden
- Prior art keywords
- methods
- new
- trombin
- inhibitive
- associations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8203887A SE8203887D0 (sv) | 1982-06-23 | 1982-06-23 | Nya trombininhiberande foreningar |
AT83850149T ATE22882T1 (de) | 1982-06-23 | 1983-06-02 | Derivate von n-alpha-arylsulfonyl-p-guanidinophenylalanin und arzneimittel mit thrombininhibitor-wirkung. |
EP83850149A EP0097630B1 (fr) | 1982-06-23 | 1983-06-02 | Dérivés de N-alpha-arylsulfonyl-p-guanidino-phénylalanine utiles comme inhibiteur de la thrombine |
DE8383850149T DE3366917D1 (en) | 1982-06-23 | 1983-06-02 | New thrombin inhibiting compounds |
US06/504,338 US4537896A (en) | 1982-06-23 | 1983-06-14 | Thrombin inhibiting arylsulfonyl guanidinophenylalanine amides |
JP58111131A JPS5931757A (ja) | 1982-06-23 | 1983-06-22 | 新規なトロンビン阻害性化合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8203887A SE8203887D0 (sv) | 1982-06-23 | 1982-06-23 | Nya trombininhiberande foreningar |
Publications (1)
Publication Number | Publication Date |
---|---|
SE8203887D0 true SE8203887D0 (sv) | 1982-06-23 |
Family
ID=20347156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8203887A SE8203887D0 (sv) | 1982-06-23 | 1982-06-23 | Nya trombininhiberande foreningar |
Country Status (6)
Country | Link |
---|---|
US (1) | US4537896A (fr) |
EP (1) | EP0097630B1 (fr) |
JP (1) | JPS5931757A (fr) |
AT (1) | ATE22882T1 (fr) |
DE (1) | DE3366917D1 (fr) |
SE (1) | SE8203887D0 (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62245932A (ja) * | 1986-04-18 | 1987-10-27 | Haamo Sogo Kenkyusho:Kk | 光検出装置 |
US5200322A (en) * | 1986-09-19 | 1993-04-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Method for assaying protein C and measuring kit for the same |
CA2005741C (fr) * | 1988-12-26 | 1998-06-02 | Hiroyoshi Hidaka | Sulfonoaminoquinolines ayant une activite de relaxation des muscles lisses des vaisseaux |
US5245034A (en) * | 1988-12-26 | 1993-09-14 | Kiroyoshi Hidaka | Compound having vessel smooth muscle relaxation activity |
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
US5256812A (en) * | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
ZA92970B (en) * | 1991-02-12 | 1992-10-28 | Hoechst Ag | Arylsulfonylureas,processes for their preparation,and their use as herbicides and growth regulators |
DE4115468A1 (de) * | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
ES2084176T3 (es) * | 1991-09-05 | 1996-05-01 | Pharno Wedropharm Gmbh | Derivados de sulfonamidas aromaticas, su uso como inhibidores de enzimas y composiciones farmaceuticas que los contienen. |
PH31294A (en) * | 1992-02-13 | 1998-07-06 | Thomae Gmbh Dr K | Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them. |
US5227490A (en) * | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
TW223629B (fr) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
FR2689130B1 (fr) * | 1992-03-30 | 1994-05-27 | Synthelabo | Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique. |
DE4225853A1 (de) * | 1992-08-05 | 1994-02-10 | Behringwerke Ag | Granulozytenbindende Antikörperfragmente, ihre Herstellung und Verwendung |
DE4242655A1 (de) * | 1992-12-17 | 1994-06-23 | Behringwerke Ag | Verwendung von Thrombin-Inhibitoren zur Inhibition okularer Fibrinbildung |
US5248673A (en) * | 1992-12-23 | 1993-09-28 | Bristol-Myers Squibb Co. | Bisamidine derivatives as thrombin inhibitors |
US5607937A (en) * | 1993-02-10 | 1997-03-04 | Pentapharm Ag | Piperazides of substituted phenylalanine derivatives as thrombin inhibitors |
TW394760B (en) * | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
FR2710067B1 (fr) * | 1993-09-14 | 1995-10-20 | Synthelabo | Procédé de préparation de 2-amino-5-(1H-imidazol-4-yl)-1-oxopentylpipéridine. |
AU3107795A (en) * | 1994-08-09 | 1996-03-07 | Pentapharm Ag | Inhibitors of the benzamidine type |
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
AU2629795A (en) * | 1994-12-12 | 1996-07-03 | Chugai Seiyaku Kabushiki Kaisha | Aniline derivative having the effect of inhibiting nitrogen monoxide synthase |
KR0173034B1 (ko) * | 1995-04-28 | 1999-03-30 | 성재갑 | 선택적 트롬빈 억제제 |
US5612378A (en) * | 1995-06-06 | 1997-03-18 | 3-Dimensional Pharmaceuticals, Inc. | Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors |
AU1608397A (en) | 1996-02-02 | 1997-08-22 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
GB9602294D0 (en) * | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
TR199900303T2 (xx) * | 1996-08-14 | 1999-06-21 | Zeneca Limited | �kame edilmi� pirimidin t�revleri ve bunlar�n farmas�tik kullan�m�. |
UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
ATE242774T1 (de) | 1997-02-13 | 2003-06-15 | Astrazeneca Ab | Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden |
US6440972B1 (en) | 1997-02-13 | 2002-08-27 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
KR19980076024A (ko) * | 1997-04-04 | 1998-11-16 | 성재갑 | 경구투여가 가능한 선택적 트롬빈 억제제 |
GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
WO2000039092A1 (fr) * | 1998-12-24 | 2000-07-06 | Eli Lilly And Company | AMIDES HETEROCYCLIQUES INHIBITEURS DU FACTEUR Xa |
GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
DE10005631A1 (de) | 2000-02-09 | 2001-08-23 | Max Planck Gesellschaft | Arginin-Mimetika als Faktor X¶a¶-Inhibitoren |
WO2005033068A1 (fr) * | 2003-10-06 | 2005-04-14 | Oy Juvantia Pharma Ltd | Recepteur 1 et/ou 4 de somatostatine, agonistes et antagonistes selectifs |
CN117143179B (zh) * | 2023-09-18 | 2024-07-12 | 安徽峆一药业股份有限公司 | 一种凝血酶发色底物s-2238的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE380257B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser |
US3978045A (en) * | 1973-08-13 | 1976-08-31 | Mitsubishi Chemical Industries Ltd. | N2 -dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof |
NL7512637A (nl) * | 1974-11-08 | 1976-05-11 | Mitsubishi Chem Ind | Werkwijze ter bereiding van een geneesmiddel, het aldus gevormde geneesmiddel en werkwijze voor de bereiding van actieve component. |
US4069323A (en) * | 1974-11-08 | 1978-01-17 | Mitsubishi Chemical Industries Ltd. | N2 -substituted-L-arginine derivatives and the pharmaceutically acceptable acid addition salts thereof |
NZ182812A (en) * | 1975-12-09 | 1984-08-24 | Mitsubishi Chem Ind | N2-aryl(or aralkyl)sulphonyl-l-argininamides and pharmaceutical compositions |
CA1102316A (fr) * | 1975-12-09 | 1981-06-02 | Shosuke Okamoto | Traduction non-disponible |
US4089957A (en) * | 1976-06-11 | 1978-05-16 | Ab Kabi | Therapeutic compositions against recurrent thrombosis |
-
1982
- 1982-06-23 SE SE8203887A patent/SE8203887D0/xx unknown
-
1983
- 1983-06-02 DE DE8383850149T patent/DE3366917D1/de not_active Expired
- 1983-06-02 EP EP83850149A patent/EP0097630B1/fr not_active Expired
- 1983-06-02 AT AT83850149T patent/ATE22882T1/de active
- 1983-06-14 US US06/504,338 patent/US4537896A/en not_active Expired - Fee Related
- 1983-06-22 JP JP58111131A patent/JPS5931757A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE22882T1 (de) | 1986-11-15 |
DE3366917D1 (en) | 1986-11-20 |
US4537896A (en) | 1985-08-27 |
EP0097630B1 (fr) | 1986-10-15 |
JPS5931757A (ja) | 1984-02-20 |
EP0097630A3 (en) | 1984-07-04 |
EP0097630A2 (fr) | 1984-01-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE8203887D0 (sv) | Nya trombininhiberande foreningar | |
HUP9802814A2 (hu) | Szelektív béta3 adrenergiás agonista hatású vegyületek, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk | |
ATE60761T1 (de) | Chinazolinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
ZA897660B (en) | Biologically active compounds | |
ES8206474A1 (es) | Un procedimiento para la obtencion de un derivado acilado sustituido de acido octahidro-1h-indol-2-carboxilico | |
ES8705372A1 (es) | Un procedimiento para la preparacion de derivados monoamidi-cos de etilendiamina | |
ATE79755T1 (de) | N-(2-carboxy)-ethyl-1,8-naphthalenimid und dessen salze zur behandlung von diabetischen retinopathien und neuropathien. | |
ES495106A0 (es) | Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos | |
ATE74138T1 (de) | Heptanoyl-glu-asp-ala-amino-saeureimmunstimulanten. | |
ATE179071T1 (de) | Verwendung eines thioesters zur herstellung von pharmazeutischen zusammensetzungen zur behandlung von ischämie und von reperfusion-syndromen | |
ES8604960A1 (es) | Procedimiento para preparar derivados de 1,6-naftiridina | |
HUP9900668A2 (hu) | Szulfamidsavszármazékok, N-acil-szulfonamidok és szulfonil-karbamát-származékok alkalmazása lipoproteinszintet csökkentő gyógyászati készítmények előállítására | |
GB1416018A (en) | Therapeutic compositions and method of treatment | |
FR2639944B1 (fr) | Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
NO834149L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive 1-aroyl-5-okso-2-pyrrolidinpropansyrederivater | |
SE7905051L (sv) | Nya sulfonamider | |
ES8407021A1 (es) | Un procedimiento para la preparacion de derivados de acido 5-oxo-2-pirrolidinpropanoico. | |
DK210387A (da) | Heterocykliske forbindelser og fremgangsmaade til deres fremstilling samt farmaceutiske midler indeholdende disse | |
GB1059182A (en) | Dibenzodiazepine derivatives and the manufacture thereof | |
TH2113EX (th) | สารประกอบแอโรมาติค |