SE8107520L - 7-acylaminocefalosporansyraderivat och forfarande for framstellning derav - Google Patents
7-acylaminocefalosporansyraderivat och forfarande for framstellning deravInfo
- Publication number
- SE8107520L SE8107520L SE8107520A SE8107520A SE8107520L SE 8107520 L SE8107520 L SE 8107520L SE 8107520 A SE8107520 A SE 8107520A SE 8107520 A SE8107520 A SE 8107520A SE 8107520 L SE8107520 L SE 8107520L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- acid derivatives
- derivatives
- protected
- procedures
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- FZEVMBJWXHDLDB-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical compound S1CC=CN2C(=O)C[C@H]21 FZEVMBJWXHDLDB-ZCFIWIBFSA-N 0.000 abstract 1
- SXBDXXFTJVHSAF-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-3-en-8-one Chemical compound S1C=CCN2C(=O)C[C@H]21 SXBDXXFTJVHSAF-ZCFIWIBFSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 125000005333 aroyloxy group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000005201 cycloalkylcarbonyloxy group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000005633 phthalidyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8040108 | 1980-12-15 | ||
| JP18329980A JPS57106684A (en) | 1980-12-23 | 1980-12-23 | Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation |
| GB8041516 | 1980-12-30 | ||
| GB8108135 | 1981-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8107520L true SE8107520L (sv) | 1982-06-16 |
Family
ID=27449218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8107520A SE8107520L (sv) | 1980-12-15 | 1981-12-15 | 7-acylaminocefalosporansyraderivat och forfarande for framstellning derav |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4477447A ( ) |
| AT (1) | AT376983B ( ) |
| DE (1) | DE3149578A1 ( ) |
| DK (1) | DK554481A ( ) |
| ES (1) | ES8303422A1 ( ) |
| FR (1) | FR2496106B1 ( ) |
| GB (1) | GB2092575B ( ) |
| GR (1) | GR76690B ( ) |
| IT (1) | IT1142096B ( ) |
| NL (1) | NL8105658A ( ) |
| SE (1) | SE8107520L ( ) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4703046A (en) * | 1978-09-08 | 1987-10-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds and processes for preparation thereof |
| EP0136266A3 (de) * | 1983-09-22 | 1986-03-26 | Ciba-Geigy Ag | 7beta-Acylamido-3-cephem-4-carbonsäureester, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren |
| US4914091A (en) * | 1984-04-02 | 1990-04-03 | American Cyanamid Company | Esters of cephalosporin derivitives |
| US5389625A (en) * | 1989-10-28 | 1995-02-14 | Kyoto Pharmaceutical Industries, Ltd. | Cephalosporin compounds |
| JP6151257B2 (ja) | 2011-09-09 | 2017-06-21 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 肺内感染症の治療方法 |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| US20140274993A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane-tazobactam pharmaceutical compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| EP3100732A1 (en) | 2013-03-15 | 2016-12-07 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US10376496B2 (en) | 2013-09-09 | 2019-08-13 | Merck, Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
| US4370326A (en) * | 1977-09-13 | 1983-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds and composition |
| MA18686A1 (fr) * | 1978-07-07 | 1980-10-01 | Ciba Geigy Ag | Composes aminothiazoliques |
| EP0009671B1 (en) * | 1978-09-12 | 1984-06-13 | Fujisawa Pharmaceutical Co., Ltd. | Starting compounds for preparing cephem compounds and processes for their preparation |
| JPS5543011A (en) * | 1978-09-20 | 1980-03-26 | Shionogi & Co Ltd | 7-halothiazolylalkoxyiminoacetamido-3-cephem compound |
| EP0054512A3 (de) * | 1980-12-12 | 1983-08-03 | Ciba-Geigy Ag | Cephalosporinester, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate |
| AU8166182A (en) * | 1981-03-23 | 1982-09-30 | Kyoto Yakuhin Kogyo K.K. | Cephalosporin derivatives |
| JPS57193489A (en) * | 1981-05-21 | 1982-11-27 | Fujisawa Pharmaceut Co Ltd | Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation |
-
1981
- 1981-12-14 ES ES507942A patent/ES8303422A1/es not_active Expired
- 1981-12-14 DK DK554481A patent/DK554481A/da not_active Application Discontinuation
- 1981-12-14 IT IT8125581A patent/IT1142096B/it active
- 1981-12-15 GR GR66790A patent/GR76690B/el unknown
- 1981-12-15 AT AT0536881A patent/AT376983B/de not_active IP Right Cessation
- 1981-12-15 FR FR8123457A patent/FR2496106B1/fr not_active Expired
- 1981-12-15 GB GB8137724A patent/GB2092575B/en not_active Expired
- 1981-12-15 SE SE8107520A patent/SE8107520L/ not_active Application Discontinuation
- 1981-12-15 DE DE19813149578 patent/DE3149578A1/de not_active Withdrawn
- 1981-12-15 NL NL8105658A patent/NL8105658A/nl not_active Application Discontinuation
-
1982
- 1982-02-24 US US06/351,858 patent/US4477447A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IT1142096B (it) | 1986-10-08 |
| GB2092575A (en) | 1982-08-18 |
| FR2496106A1 (fr) | 1982-06-18 |
| IT8125581A0 (it) | 1981-12-14 |
| DE3149578A1 (de) | 1982-09-09 |
| DK554481A (da) | 1982-06-16 |
| AT376983B (de) | 1985-01-25 |
| ES507942A0 (es) | 1983-02-01 |
| GB2092575B (en) | 1985-07-03 |
| FR2496106B1 (fr) | 1985-07-19 |
| GR76690B ( ) | 1984-08-24 |
| US4477447A (en) | 1984-10-16 |
| NL8105658A (nl) | 1982-07-01 |
| ATA536881A (de) | 1984-06-15 |
| ES8303422A1 (es) | 1983-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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