SE8105597L - DEVICE AND PROCEDURE FOR IMPLEMENTING CHEMICAL PROCESSES IN SEQUENCE - Google Patents

DEVICE AND PROCEDURE FOR IMPLEMENTING CHEMICAL PROCESSES IN SEQUENCE

Info

Publication number
SE8105597L
SE8105597L SE8105597A SE8105597A SE8105597L SE 8105597 L SE8105597 L SE 8105597L SE 8105597 A SE8105597 A SE 8105597A SE 8105597 A SE8105597 A SE 8105597A SE 8105597 L SE8105597 L SE 8105597L
Authority
SE
Sweden
Prior art keywords
chamber
sample
chemical processes
procedure
sequence
Prior art date
Application number
SE8105597A
Other languages
Swedish (sv)
Other versions
SE466223B (en
Inventor
L E Hood
M W Hunkapiller
W J Dreyer
R M Hewick
A W Stark
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of SE8105597L publication Critical patent/SE8105597L/en
Publication of SE466223B publication Critical patent/SE466223B/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F16K7/14—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat
    • F16K7/17—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat the diaphragm being actuated by fluid pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00396—Membrane valves
    • B01J2219/00398—Membrane valves in multiple arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

An improved apparatus and method for the sequential performance of chemical processes on a sample of chemical material wherein the sample is embedded in a solid matrix (194) of fluid permeable material, eg polymer material, located within a reaction chamber and is sequentially subjected to a plurality of fluids passed through the chamber in a pressurized stream, causing chemical interaction between the sample and the fluids. The matrix may be supported on a porous layer (190) across the chamber or may be applied to the chamber walls. Also described are a system for automatically performing sequential degradation analysis of protein or peptide chains and valve means (comprising a valve block (182) having a plurality of membrane- operated valve sites (78-82)) and a conversion flask for use in such a system. <IMAGE>
SE8105597A 1980-09-23 1981-09-22 DEVICE AND PROCEDURES FOR DETERMINING THE LINEAR SEQUENCE OF AMINO ACID UNITS IN PROTEINS AND PEPTIDES SE466223B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19010080A 1980-09-23 1980-09-23

Publications (2)

Publication Number Publication Date
SE8105597L true SE8105597L (en) 1982-05-06
SE466223B SE466223B (en) 1992-01-13

Family

ID=22700018

Family Applications (3)

Application Number Title Priority Date Filing Date
SE8105597A SE466223B (en) 1980-09-23 1981-09-22 DEVICE AND PROCEDURES FOR DETERMINING THE LINEAR SEQUENCE OF AMINO ACID UNITS IN PROTEINS AND PEPTIDES
SE8802124A SE501968C2 (en) 1980-09-23 1988-06-07 conversion Piston
SE8802125A SE8802125D0 (en) 1980-09-23 1988-06-07 Valve device

Family Applications After (2)

Application Number Title Priority Date Filing Date
SE8802124A SE501968C2 (en) 1980-09-23 1988-06-07 conversion Piston
SE8802125A SE8802125D0 (en) 1980-09-23 1988-06-07 Valve device

Country Status (6)

Country Link
JP (1) JPS57110962A (en)
CA (1) CA1163425A (en)
DE (1) DE3137875C2 (en)
FR (1) FR2490505B1 (en)
GB (3) GB2084899B (en)
SE (3) SE466223B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2544720B1 (en) * 1983-04-19 1987-11-27 California Inst Of Techn IMPROVED INSTALLATION AND METHOD FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS, IN PARTICULAR OLIGONUCLEOTIDES
GB2143240B (en) * 1983-07-13 1988-01-13 Nippon Zeon Co Apparatus for synthesizing polynucleotide
JPS60105691A (en) * 1983-11-14 1985-06-11 Nippon Zeon Co Ltd Apparatus for synthesizing polynucleotide
CA1218930A (en) * 1984-02-22 1987-03-10 Allelix Biopharmaceuticals Inc. Device for performing quantitative chemical and immunochemical assays
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
DE3508162C1 (en) * 1985-03-07 1986-06-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Pipe system for laboratory purposes
EP0256676B1 (en) * 1986-08-15 1994-10-05 Beckman Research Institute of the City of Hope A continuous flow reactor for peptide sequenators
US4773446A (en) * 1986-08-27 1988-09-27 Porton Instruments, Inc. Valve block assembly
DE3637869A1 (en) * 1986-11-06 1988-05-19 Draegerwerk Ag MULTIPLE HOLDER FOR TEST TUBES
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
EP0388224A3 (en) * 1989-03-17 1991-05-22 Seiko Instruments Inc. Method and apparatus for effecting chemical treatment
JPH02307059A (en) * 1989-05-23 1990-12-20 Seiko Instr Inc Reaction vessel
US5605839A (en) * 1990-04-11 1997-02-25 Ludwig Institute For Cancer Research Methods and apparatus for use in sequential chemical reactions
DE9109797U1 (en) * 1991-08-07 1991-09-26 Herbert Knauer Wiss Geraetebau
IT1255014B (en) * 1992-03-27 1995-10-13 Instrumentation Lab Spa FLUIDS HANDLING AND INTERCEPTION DEVICES
US5203368A (en) * 1992-07-29 1993-04-20 Protein Technologies Inc. Matrix of valves
US5641459A (en) * 1995-08-17 1997-06-24 Pharmacia Biotech Ab Machine for synthesizing oligonucleotides
DE19652823A1 (en) * 1996-12-18 1998-03-26 Guenter Prof Dr Fuhr Three dimension micro-system spacers
GB2409411A (en) * 2003-12-22 2005-06-29 William Thomas Dennis Bates Blood collection system
CN103974762A (en) * 2011-09-30 2014-08-06 通用电气健康护理有限公司 Reactor for multi-step radiochemistry

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3077766A (en) 1960-07-08 1963-02-19 Phillips Petroleum Co Shut off valve for chromatographic system
DE1227855B (en) * 1960-07-12 1966-11-03 Ichthyol Ges Process for the production of enzyme bodies for the implementation of enzymatic reactions
US3717436A (en) 1971-01-25 1973-02-20 Beckman Ind Inc Process for the sequential degradation of peptide chains
BE786213A (en) * 1971-07-13 1973-01-15 Technicon Instr METHOD AND APPARATUS FOR THE ANALYSIS OF SAMPLES, IN PARTICULAR DESANG
US3725010A (en) 1971-08-23 1973-04-03 Beckman Instruments Inc Apparatus for automatically performing chemical processes
BE795316A (en) * 1972-02-11 1973-05-29 Nat Patent Dev Corp CATALYTIC SYSTEM PRESENTING SUSTAINABLE ENZYMATIC ACTIVITY AND INCREASED STABILITY
JPS5117438B2 (en) * 1972-05-26 1976-06-02
GB1427192A (en) * 1972-05-26 1976-03-10 Kannegiesser M Apparatus for manufacturing mouldings from expandable synthetic plastics more particularly polyurethane
DE2308088C2 (en) * 1973-02-19 1983-03-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Process for the automated determination of the amino acid sequence and device for its implementation
US3892531A (en) * 1973-07-05 1975-07-01 Beckman Instruments Inc Apparatus for sequencing peptides and proteins
US3959307A (en) 1974-02-15 1976-05-25 Wittmann Brigitte Method to determine automatically the sequence of amino acids
US3951167A (en) 1974-12-05 1976-04-20 E. I. Du Pont De Nemours And Company Fluid handling assembly
US4065412A (en) * 1976-05-07 1977-12-27 Durrum Instrument Corporation Peptide or protein sequencing method and apparatus
US4119120A (en) 1976-11-29 1978-10-10 Beckman Instruments, Inc. Fluid switch
US4252769A (en) * 1979-12-26 1981-02-24 California Institute Of Technology Apparatus for the performance of chemical processes

Also Published As

Publication number Publication date
FR2490505A1 (en) 1982-03-26
JPS57110962A (en) 1982-07-10
SE501968C2 (en) 1995-07-03
SE8802125A0 (en) 1988-06-07
GB2146741B (en) 1985-11-20
JPH0256635B2 (en) 1990-11-30
GB8333306D0 (en) 1984-01-18
GB8333305D0 (en) 1984-01-18
GB2146550B (en) 1985-11-13
FR2490505B1 (en) 1986-01-03
GB2146550A (en) 1985-04-24
DE3137875C2 (en) 1995-11-02
SE8802125D0 (en) 1988-06-07
GB2084899B (en) 1985-05-30
SE8802124D0 (en) 1988-06-07
GB2084899A (en) 1982-04-21
GB2146741A (en) 1985-04-24
CA1163425A (en) 1984-03-13
SE466223B (en) 1992-01-13
DE3137875A1 (en) 1982-05-06
SE8802124L (en) 1988-06-07

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