SE8008334L - Analogiforfarande for framstellning av 16-fenoxi- och 16-(o, m eller p)-substituerade fenoxiprosta-4,5,13-triensyraderivat - Google Patents

Analogiforfarande for framstellning av 16-fenoxi- och 16-(o, m eller p)-substituerade fenoxiprosta-4,5,13-triensyraderivat

Info

Publication number
SE8008334L
SE8008334L SE8008334A SE8008334A SE8008334L SE 8008334 L SE8008334 L SE 8008334L SE 8008334 A SE8008334 A SE 8008334A SE 8008334 A SE8008334 A SE 8008334A SE 8008334 L SE8008334 L SE 8008334L
Authority
SE
Sweden
Prior art keywords
alpha
methyl
phenoxy
compound
substituted
Prior art date
Application number
SE8008334A
Other languages
English (en)
Other versions
SE424636B (sv
Inventor
Joseph M Muchowsky
John H Fried
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of SE8008334L publication Critical patent/SE8008334L/sv
Publication of SE424636B publication Critical patent/SE424636B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (1)

Patentkrav Analogiforfarande for framStAllning av en racemisk eller 8R-antimer forening med den allmAnna formeln OH COOP C ° i vilken R betecknar vate eller lAgre alkyl med 1-4 kolatomer, eller farmaceutiskt godtagbara, icke-toxiska salter av foreningar, I vilka R betecknar vale, 1 betecknar vAte, metyl eller etyl, R2 betecknar vAte-,o-, m- eller p-halo (fluor, klor eller brom), o-, m- eller ptrifluormetyl, o-, m- eller p-lAgre alkyl eller o-, m- eller p-lagre alkoxi orb vAglinjerna (1) anger a- eller 8-konfiguration eller bland- ningar dArav, forutsatt ati■,d& Ri stAr is& stir hydroxi- vilka R1', R2 och vAglinjerna. (?) betecknar detsamma som oven, b) omvandling av den fria syraforeningen enligt oven till en alkylester eller till ett farmaceutiskt godtagbart salt dArav p& och for sig kAnt satt. gruppen, som Ar bunden till samma kolatom som Ri,1 0-stAllning och di R1 stAr i 8-stallning, s& stAr hydroxigruppen, corn Ar bunden till samma kolatom sop 1ia-stAllning, kAnnetecknat av ett eller flora av 101jande steg: a) fortv&lning av en forening med formlerna OAcOAc COOMeCOOMe CH C OH OHOAc2 R2 vilka 122 och vAglinjernabetecknar detsamma som oven,
1. be- . tecknar metyl eller etyl och Ac betecknar acetyl, for att framstAlla en forening med foma
SE8008334A 1975-06-23 1980-11-27 Analogiforfarande for framstellning av 16-fenoxi- och 16-(o, m eller p)-substituerade fenoxiprosta-4,5,13-triensyraderivat SE424636B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58921875A 1975-06-23 1975-06-23
US05/643,219 US3985791A (en) 1975-06-23 1975-12-22 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

Publications (2)

Publication Number Publication Date
SE8008334L true SE8008334L (sv) 1980-11-27
SE424636B SE424636B (sv) 1982-08-02

Family

ID=27080476

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7607075A SE417710B (sv) 1975-06-23 1976-06-21 16-fenoxi- och 16-substituerade fenoxiprosta-4,5,13-triensyraderivat till anvendning for reglering av reproduktionscyklen hos hondeggdjur
SE8008334A SE424636B (sv) 1975-06-23 1980-11-27 Analogiforfarande for framstellning av 16-fenoxi- och 16-(o, m eller p)-substituerade fenoxiprosta-4,5,13-triensyraderivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7607075A SE417710B (sv) 1975-06-23 1976-06-21 16-fenoxi- och 16-substituerade fenoxiprosta-4,5,13-triensyraderivat till anvendning for reglering av reproduktionscyklen hos hondeggdjur

Country Status (13)

Country Link
US (1) US3985791A (sv)
AU (1) AU505899B2 (sv)
CA (1) CA1064027A (sv)
DE (1) DE2627910C2 (sv)
ES (1) ES449162A1 (sv)
FR (1) FR2315263B1 (sv)
GB (1) GB1546823A (sv)
HK (1) HK8780A (sv)
IE (1) IE43916B1 (sv)
MX (1) MX3949E (sv)
MY (1) MY8000274A (sv)
NL (1) NL181628C (sv)
SE (2) SE417710B (sv)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178457A (en) * 1978-07-10 1979-12-11 Syntex (U.S.A.) Inc. (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof
US4389414A (en) * 1981-05-11 1983-06-21 Syntex (U.S.A.) Inc. Prostaglandin compositions
US4912235A (en) * 1983-12-22 1990-03-27 Syntex (U.S.A.) Inc. Processes and intermediates for making 16-phenoxy- and 16-substituted phenoxy-prostatrienoic acid derivatives and their stereoisomers
US4804787A (en) * 1983-12-22 1989-02-14 Syntex (U.S.A.) Inc. Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
DE3414509A1 (de) * 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 9-halogen-prostaglandine
CA1246560A (en) * 1984-10-09 1988-12-13 Gary F. Cooper Intermediates for making 16-phenoxy and 16- substituted phenoxy-prostatrienoic acid derivatives
US4778904A (en) * 1985-09-13 1988-10-18 Syntex (U.S.A.) Inc. Intermediates for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4929740A (en) * 1984-10-09 1990-05-29 Syntex (U.S.A.) Inc. Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4997823A (en) * 1986-02-18 1991-03-05 Syntex (U.S.A.) Inc. Anti-infective injectable formulations
PH23349A (en) * 1986-02-18 1989-07-14 Syntex Inc Anti-infective injectable formulations
US4755531A (en) * 1986-08-11 1988-07-05 Syntex (U.S.A.) Inc. Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents
US4689419A (en) * 1986-11-14 1987-08-25 G. D. Searle & Co. Novel intermediate compounds in a process for producing 16-phenoxy- and 16-substituted phenoxy-9-keto-prostatrienoic acid derivatives
US5248788A (en) * 1988-12-13 1993-09-28 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US4916238A (en) * 1988-12-13 1990-04-10 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US5571936A (en) * 1994-09-30 1996-11-05 Korea Institute Of Science And Technology Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20060128810A1 (en) * 2002-10-10 2006-06-15 Kyoto University Remedies for allergic diseases
JP4666257B2 (ja) 2003-07-25 2011-04-06 小野薬品工業株式会社 軟骨関連疾患治療剤
EP2143712A1 (en) * 2008-07-10 2010-01-13 Sandoz AG Improved Process for the Production of Prostaglandins and Prostaglandin Analogs
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
AU2009340420A1 (en) * 2008-10-29 2010-08-26 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
CN101948484B (zh) * 2010-09-19 2012-07-11 武汉武药科技有限公司 一种曲伏前列素中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879438A (en) * 1973-03-05 1975-04-22 Syntex Inc 4,5,13-Prostatrienoic acid derivatives
DD118856A5 (sv) * 1972-11-08 1976-03-20
US3864387A (en) 1973-05-21 1975-02-04 Upjohn Co 5-Oxa phenyl-and phenoxy-substituted prostaglandin F{HD 1{301 {0 {B analogs
US3873598A (en) * 1973-07-06 1975-03-25 Syntex Inc 4,5,10,13 prostatetraenoic acid derivatives
GB1445794A (en) * 1974-02-18 1976-08-11 Ici Ltd Epimerisation process for lactone intermediates for prostaglandins

Also Published As

Publication number Publication date
SE417710B (sv) 1981-04-06
SE7607075L (sv) 1976-12-24
SE424636B (sv) 1982-08-02
IE43916L (en) 1976-12-23
AU1507976A (en) 1978-01-05
DE2627910A1 (de) 1977-01-13
NL181628C (nl) 1987-10-01
CA1064027A (en) 1979-10-09
HK8780A (en) 1980-03-14
ES449162A1 (es) 1977-12-16
GB1546823A (en) 1979-05-31
MX3949E (es) 1981-10-09
IE43916B1 (en) 1981-07-01
DE2627910C2 (de) 1985-01-17
FR2315263B1 (fr) 1978-11-10
MY8000274A (en) 1980-12-31
FR2315263A1 (fr) 1977-01-21
AU505899B2 (en) 1979-12-06
NL7606723A (nl) 1976-12-27
US3985791A (en) 1976-10-12

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