FR2315263B1 - Derives de l'acide 16-phenoxy et 16-phenoxy substitues prostatrienoique et leur procede de preparation - Google Patents

Derives de l'acide 16-phenoxy et 16-phenoxy substitues prostatrienoique et leur procede de preparation

Info

Publication number
FR2315263B1
FR2315263B1 FR7618857A FR7618857A FR2315263B1 FR 2315263 B1 FR2315263 B1 FR 2315263B1 FR 7618857 A FR7618857 A FR 7618857A FR 7618857 A FR7618857 A FR 7618857A FR 2315263 B1 FR2315263 B1 FR 2315263B1
Authority
FR
France
Prior art keywords
phenoxy
prostatrienoic
preparation process
substitutes
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7618857A
Other languages
English (en)
Other versions
FR2315263A1 (fr
Inventor
Joseph M Muchowsky
John H Fried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of FR2315263A1 publication Critical patent/FR2315263A1/fr
Application granted granted Critical
Publication of FR2315263B1 publication Critical patent/FR2315263B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
FR7618857A 1975-06-23 1976-06-21 Derives de l'acide 16-phenoxy et 16-phenoxy substitues prostatrienoique et leur procede de preparation Expired FR2315263B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58921875A 1975-06-23 1975-06-23
US05/643,219 US3985791A (en) 1975-06-23 1975-12-22 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

Publications (2)

Publication Number Publication Date
FR2315263A1 FR2315263A1 (fr) 1977-01-21
FR2315263B1 true FR2315263B1 (fr) 1978-11-10

Family

ID=27080476

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7618857A Expired FR2315263B1 (fr) 1975-06-23 1976-06-21 Derives de l'acide 16-phenoxy et 16-phenoxy substitues prostatrienoique et leur procede de preparation

Country Status (13)

Country Link
US (1) US3985791A (fr)
AU (1) AU505899B2 (fr)
CA (1) CA1064027A (fr)
DE (1) DE2627910C2 (fr)
ES (1) ES449162A1 (fr)
FR (1) FR2315263B1 (fr)
GB (1) GB1546823A (fr)
HK (1) HK8780A (fr)
IE (1) IE43916B1 (fr)
MX (1) MX3949E (fr)
MY (1) MY8000274A (fr)
NL (1) NL181628C (fr)
SE (2) SE417710B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178457A (en) * 1978-07-10 1979-12-11 Syntex (U.S.A.) Inc. (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof
US4389414A (en) * 1981-05-11 1983-06-21 Syntex (U.S.A.) Inc. Prostaglandin compositions
US4912235A (en) * 1983-12-22 1990-03-27 Syntex (U.S.A.) Inc. Processes and intermediates for making 16-phenoxy- and 16-substituted phenoxy-prostatrienoic acid derivatives and their stereoisomers
US4804787A (en) * 1983-12-22 1989-02-14 Syntex (U.S.A.) Inc. Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
DE3414509A1 (de) * 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 9-halogen-prostaglandine
CA1246560A (fr) * 1984-10-09 1988-12-13 Gary F. Cooper Intermediaires pour la production de derives de l'acide 16-phenoxy-prostatrienoique et de l'acide 16-phenoxy-prostatrienoique substitue
US4778904A (en) * 1985-09-13 1988-10-18 Syntex (U.S.A.) Inc. Intermediates for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4929740A (en) * 1984-10-09 1990-05-29 Syntex (U.S.A.) Inc. Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4997823A (en) * 1986-02-18 1991-03-05 Syntex (U.S.A.) Inc. Anti-infective injectable formulations
PH23349A (en) * 1986-02-18 1989-07-14 Syntex Inc Anti-infective injectable formulations
US4755531A (en) * 1986-08-11 1988-07-05 Syntex (U.S.A.) Inc. Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents
US4689419A (en) * 1986-11-14 1987-08-25 G. D. Searle & Co. Novel intermediate compounds in a process for producing 16-phenoxy- and 16-substituted phenoxy-9-keto-prostatrienoic acid derivatives
US5248788A (en) * 1988-12-13 1993-09-28 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US4916238A (en) * 1988-12-13 1990-04-10 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US5571936A (en) * 1994-09-30 1996-11-05 Korea Institute Of Science And Technology Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20060128810A1 (en) * 2002-10-10 2006-06-15 Kyoto University Remedies for allergic diseases
JP4666257B2 (ja) 2003-07-25 2011-04-06 小野薬品工業株式会社 軟骨関連疾患治療剤
EP2143712A1 (fr) * 2008-07-10 2010-01-13 Sandoz AG Procédé amélioré pour la production de prostaglandines et d'analogues de la prostaglandine
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
AU2009340420A1 (en) * 2008-10-29 2010-08-26 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
CN101948484B (zh) * 2010-09-19 2012-07-11 武汉武药科技有限公司 一种曲伏前列素中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879438A (en) * 1973-03-05 1975-04-22 Syntex Inc 4,5,13-Prostatrienoic acid derivatives
DD118856A5 (fr) * 1972-11-08 1976-03-20
US3864387A (en) 1973-05-21 1975-02-04 Upjohn Co 5-Oxa phenyl-and phenoxy-substituted prostaglandin F{HD 1{301 {0 {B analogs
US3873598A (en) * 1973-07-06 1975-03-25 Syntex Inc 4,5,10,13 prostatetraenoic acid derivatives
GB1445794A (en) * 1974-02-18 1976-08-11 Ici Ltd Epimerisation process for lactone intermediates for prostaglandins

Also Published As

Publication number Publication date
SE417710B (sv) 1981-04-06
SE7607075L (sv) 1976-12-24
SE424636B (sv) 1982-08-02
IE43916L (en) 1976-12-23
AU1507976A (en) 1978-01-05
DE2627910A1 (de) 1977-01-13
NL181628C (nl) 1987-10-01
CA1064027A (fr) 1979-10-09
HK8780A (en) 1980-03-14
ES449162A1 (es) 1977-12-16
SE8008334L (sv) 1980-11-27
GB1546823A (en) 1979-05-31
MX3949E (es) 1981-10-09
IE43916B1 (en) 1981-07-01
DE2627910C2 (de) 1985-01-17
MY8000274A (en) 1980-12-31
FR2315263A1 (fr) 1977-01-21
AU505899B2 (en) 1979-12-06
NL7606723A (nl) 1976-12-27
US3985791A (en) 1976-10-12

Similar Documents

Publication Publication Date Title
FR2315263B1 (fr) Derives de l'acide 16-phenoxy et 16-phenoxy substitues prostatrienoique et leur procede de preparation
FR2318627A1 (fr) Derives de l'acide phenylacetique et leur procede de preparation
BE857541A (fr) Derives d'acide prostanoique et leur procede de preparation
FR2304330A1 (fr) Derives acetyleniques d'aminoacides et leur procede de preparation
BE823027A (fr) Derives d'isoquinoleine et leur procede de preparation
FR2318645A1 (fr) 3-oximes d'esters de d-17a-ethynyl-19-nortestosterone et leur procede de preparation
BE818209A (fr) Derives de l'acide 7-acylamino-3-cephene-4-carboxylique et leur procede de preparation
BE838079A (fr) Derives de tetrahydroisoquinoleine et leur procede de preparation
BE822496A (fr) Derives d'acide hydratropique et leur procede de preparation
BE827870A (fr) Derives d'emidazole et leur procede de preparation
BE839836A (fr) Procede de preparation du tricosene-(9) et de l'heneicosene-(9)
BE840871A (fr) Derives de ll-oxo-prostaglandine et leur procede de preparation
BE859081A (fr) Derives de l'anthraquinone et leur procede de preparation
BE841165A (fr) Derives d'acides 8-aza-prostanoiques et leur procede de preparation
BE831855A (fr) Nouveaux derives d'oxyphenylbutazone et leur procede de preparation
FR2321885A1 (fr) Derives du vincane substitues en position 14, et leur procede de preparation
BE842841A (fr) Nouveaux derives pyrazoliques substitues en position 4, leur procede de preparation et composition pharmaceutique
BE837860A (fr) Derives d'acide glycyrrhetinique et procede pour leur preparation
BE848627A (fr) Derives substitues d'aminobenzaldehydes et leur procede de preparation,
BE856326A (fr) Nouveaux derives d'acide prostanoique et leur procede de preparation
BE821893A (fr) Derives d'adenine et leur procede de preparation
FR2327257A1 (fr) Derives de l'aminocyclitol et leur procede de preparation
FR2326180A1 (fr) Derives d'acide oxanilique et leur preparation
BE838689A (fr) Acides indanylpropioniques substitues et leur procede de preparation
BE842276A (fr) Nouveaux derives de prostane et leur procede de preparation

Legal Events

Date Code Title Description
ST Notification of lapse