SE7813279L - TIOALKANOYL ALKANIC ACID ASSOCIATIONS - Google Patents

TIOALKANOYL ALKANIC ACID ASSOCIATIONS

Info

Publication number
SE7813279L
SE7813279L SE7813279A SE7813279A SE7813279L SE 7813279 L SE7813279 L SE 7813279L SE 7813279 A SE7813279 A SE 7813279A SE 7813279 A SE7813279 A SE 7813279A SE 7813279 L SE7813279 L SE 7813279L
Authority
SE
Sweden
Prior art keywords
tioalkanoyl
hydrogen
image
alkanic acid
acid associations
Prior art date
Application number
SE7813279A
Other languages
Swedish (sv)
Inventor
M A Ondetti
M E Condon
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of SE7813279L publication Critical patent/SE7813279L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/53—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

Thioalkanoylalkanoic acid compounds and salts thereof having the formula <IMAGE> wherein R1, R2, R3 and R4 each is hydrogen or lower alkyl; R5 is hydrogen, lower alkanoyl, benzoyl or <IMAGE> A and B each is hydrogen or join together as a polymethylene chain -(CH2)n- to complete a 4-, 5- or 6- membered cycloalkyl group, and m is 0 or 1, are angiotensin converting enzyme inhibitors and are useful as hypotensive agents.
SE7813279A 1978-03-27 1978-12-22 TIOALKANOYL ALKANIC ACID ASSOCIATIONS SE7813279L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89044678A 1978-03-27 1978-03-27

Publications (1)

Publication Number Publication Date
SE7813279L true SE7813279L (en) 1979-09-28

Family

ID=25396691

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7813279A SE7813279L (en) 1978-03-27 1978-12-22 TIOALKANOYL ALKANIC ACID ASSOCIATIONS

Country Status (16)

Country Link
JP (1) JPS54128516A (en)
AU (1) AU522896B2 (en)
BE (1) BE873219A (en)
CA (1) CA1125783A (en)
CH (1) CH646421A5 (en)
DE (1) DE2855835A1 (en)
DK (1) DK586778A (en)
FR (2) FR2435467A1 (en)
GB (1) GB2017081B (en)
IE (1) IE48041B1 (en)
IT (1) IT1110882B (en)
LU (1) LU80731A1 (en)
NL (1) NL7812598A (en)
NO (1) NO784398L (en)
SE (1) SE7813279L (en)
ZA (1) ZA786929B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235885A (en) * 1979-06-25 1980-11-25 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
FR2605630B1 (en) * 1986-10-22 1989-06-30 Roussel Uclaf PROCESS FOR THE PREPARATION OF OCTAHYDROINDOLE DERIVATIVES AND PREPARATION INTERMEDIATES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762575A (en) * 1952-04-24 1956-11-28 American Cyanamid Co Omega [3-(1,2-dithiolanyl)] aliphatic acids, salts and esters and the preparation thereof
US2828321A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Keto aliphatic acid esters and method of preparing the same

Also Published As

Publication number Publication date
NO784398L (en) 1979-09-28
IT1110882B (en) 1986-01-06
AU522896B2 (en) 1982-07-01
GB2017081A (en) 1979-10-03
IE48041B1 (en) 1984-09-05
NL7812598A (en) 1979-10-01
BE873219A (en) 1979-06-29
FR2435467A1 (en) 1980-04-04
FR2421165B1 (en) 1982-02-19
GB2017081B (en) 1982-07-28
DK586778A (en) 1979-09-28
CH646421A5 (en) 1984-11-30
FR2421165A1 (en) 1979-10-26
LU80731A1 (en) 1979-04-13
DE2855835A1 (en) 1979-10-04
FR2435467B1 (en) 1983-08-19
JPS54128516A (en) 1979-10-05
AU4260478A (en) 1979-10-04
IE782481L (en) 1979-09-27
CA1125783A (en) 1982-06-15
IT7852478A0 (en) 1978-12-28
ZA786929B (en) 1979-12-27

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