GB2017081A - Thioalkanoylalkanoic acid compounds - Google Patents

Thioalkanoylalkanoic acid compounds

Info

Publication number
GB2017081A
GB2017081A GB7849941A GB7849941A GB2017081A GB 2017081 A GB2017081 A GB 2017081A GB 7849941 A GB7849941 A GB 7849941A GB 7849941 A GB7849941 A GB 7849941A GB 2017081 A GB2017081 A GB 2017081A
Authority
GB
United Kingdom
Prior art keywords
thioalkanoylalkanoic
acid compounds
hydrogen
image
benzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7849941A
Other versions
GB2017081B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB2017081A publication Critical patent/GB2017081A/en
Application granted granted Critical
Publication of GB2017081B publication Critical patent/GB2017081B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/53—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Thioalkanoylalkanoic acid compounds and salts thereof having the formula <IMAGE> wherein R1, R2, R3 and R4 each is hydrogen or lower alkyl; R5 is hydrogen, lower alkanoyl, benzoyl or <IMAGE> A and B each is hydrogen or join together as a polymethylene chain -(CH2)n- to complete a 4-, 5- or 6- membered cycloalkyl group, and m is 0 or 1, are angiotensin converting enzyme inhibitors and are useful as hypotensive agents.
GB7849941A 1978-03-27 1978-12-22 Thioalkanoylalkonaoic acid compounds Expired GB2017081B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89044678A 1978-03-27 1978-03-27

Publications (2)

Publication Number Publication Date
GB2017081A true GB2017081A (en) 1979-10-03
GB2017081B GB2017081B (en) 1982-07-28

Family

ID=25396691

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7849941A Expired GB2017081B (en) 1978-03-27 1978-12-22 Thioalkanoylalkonaoic acid compounds

Country Status (16)

Country Link
JP (1) JPS54128516A (en)
AU (1) AU522896B2 (en)
BE (1) BE873219A (en)
CA (1) CA1125783A (en)
CH (1) CH646421A5 (en)
DE (1) DE2855835A1 (en)
DK (1) DK586778A (en)
FR (2) FR2435467A1 (en)
GB (1) GB2017081B (en)
IE (1) IE48041B1 (en)
IT (1) IT1110882B (en)
LU (1) LU80731A1 (en)
NL (1) NL7812598A (en)
NO (1) NO784398L (en)
SE (1) SE7813279L (en)
ZA (1) ZA786929B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235885A (en) * 1979-06-25 1980-11-25 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
FR2605630B1 (en) * 1986-10-22 1989-06-30 Roussel Uclaf PROCESS FOR THE PREPARATION OF OCTAHYDROINDOLE DERIVATIVES AND PREPARATION INTERMEDIATES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762575A (en) * 1952-04-24 1956-11-28 American Cyanamid Co Omega [3-(1,2-dithiolanyl)] aliphatic acids, salts and esters and the preparation thereof
US2828321A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Keto aliphatic acid esters and method of preparing the same

Also Published As

Publication number Publication date
NL7812598A (en) 1979-10-01
NO784398L (en) 1979-09-28
FR2421165B1 (en) 1982-02-19
FR2435467B1 (en) 1983-08-19
IT1110882B (en) 1986-01-06
AU522896B2 (en) 1982-07-01
CA1125783A (en) 1982-06-15
DE2855835A1 (en) 1979-10-04
GB2017081B (en) 1982-07-28
IE48041B1 (en) 1984-09-05
FR2435467A1 (en) 1980-04-04
DK586778A (en) 1979-09-28
CH646421A5 (en) 1984-11-30
SE7813279L (en) 1979-09-28
LU80731A1 (en) 1979-04-13
FR2421165A1 (en) 1979-10-26
BE873219A (en) 1979-06-29
IT7852478A0 (en) 1978-12-28
ZA786929B (en) 1979-12-27
AU4260478A (en) 1979-10-04
IE782481L (en) 1979-09-27
JPS54128516A (en) 1979-10-05

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee