SE7509107L - ARYLOXY OR ARYLTIO CONTAINING SECOPROSTAGLANDINS - Google Patents

ARYLOXY OR ARYLTIO CONTAINING SECOPROSTAGLANDINS

Info

Publication number
SE7509107L
SE7509107L SE7509107A SE7509107A SE7509107L SE 7509107 L SE7509107 L SE 7509107L SE 7509107 A SE7509107 A SE 7509107A SE 7509107 A SE7509107 A SE 7509107A SE 7509107 L SE7509107 L SE 7509107L
Authority
SE
Sweden
Prior art keywords
secoprostaglandins
formula
aryltio
aryloxy
ester
Prior art date
Application number
SE7509107A
Other languages
Swedish (sv)
Inventor
Jr E J Cragoe
J B Bicking
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7509107L publication Critical patent/SE7509107L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C07D303/42—Acyclic compounds having a chain of seven or more carbon atoms, e.g. epoxidised fats
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C07C59/135—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Novel compounds of the formula (II) <IMAGE> are prepared by reacting the ester of a corresponding 12,13-epoxy compound with a compound of the formula R<6>OH or R<6>SH where -O-R<6> or -S-R<6> is equal to R<3>, and hydrolysing the resulting ester to give an acid of the formula (II). The meaning of the symbols is evident from claim 1. The secoprostaglandins are suitable in veterinary medicine as fertility regulators for oestrus synchronisation and for treating infertility, and in human medicine as postcoital contraceptives.
SE7509107A 1974-08-30 1975-08-14 ARYLOXY OR ARYLTIO CONTAINING SECOPROSTAGLANDINS SE7509107L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50212674A 1974-08-30 1974-08-30

Publications (1)

Publication Number Publication Date
SE7509107L true SE7509107L (en) 1976-03-01

Family

ID=23996457

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7509107A SE7509107L (en) 1974-08-30 1975-08-14 ARYLOXY OR ARYLTIO CONTAINING SECOPROSTAGLANDINS

Country Status (8)

Country Link
JP (1) JPS51125021A (en)
CH (1) CH613683A5 (en)
DE (1) DE2538582A1 (en)
DK (1) DK366475A (en)
FR (1) FR2282868A1 (en)
GB (1) GB1478281A (en)
NL (1) NL7509770A (en)
SE (1) SE7509107L (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018804A (en) * 1976-04-14 1977-04-19 The Upjohn Company Intermediate for synthesis of Thromboxane B2
US4150235A (en) * 1976-12-17 1979-04-17 Merck & Co., Inc. Interphenylene 11,12-secoprostaglandins
UA59384C2 (en) 1996-12-20 2003-09-15 Пфайзер, Інк. Preventing bone mass loss and recovery thereof by means of prostaglandin agonists
UA67754C2 (en) 1997-10-10 2004-07-15 Пфайзер, Інк. Prostaglandin agonists and use thereof for the treatment of bone disorders
OA12117A (en) 1999-12-22 2006-05-04 Pfizer Prod Inc EP4 receptor selective agonists in the treatment of osteoporosis.
IL141120A0 (en) 2000-01-31 2002-02-10 Pfizer Prod Inc Use of prostaglandin (pge2) receptor 4 (epa) selective agonists for the treatment of acute and chronic renal failure
RU2526203C1 (en) * 2013-02-12 2014-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Казанская государственная академия ветеринарной медицины им. Н.Э. Баумана" Method of production of anti-luteolytic blood - alb, method of treatment and prevention of postpartum obstetric and gynecological diseases in cows

Also Published As

Publication number Publication date
NL7509770A (en) 1976-03-02
DK366475A (en) 1976-03-01
DE2538582A1 (en) 1976-03-11
FR2282868A1 (en) 1976-03-26
FR2282868B1 (en) 1980-03-28
JPS51125021A (en) 1976-11-01
CH613683A5 (en) 1979-10-15
GB1478281A (en) 1977-06-29

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