GB1530667A - N2-substituted argininamides - Google Patents

N2-substituted argininamides

Info

Publication number
GB1530667A
GB1530667A GB32910/76A GB3291076A GB1530667A GB 1530667 A GB1530667 A GB 1530667A GB 32910/76 A GB32910/76 A GB 32910/76A GB 3291076 A GB3291076 A GB 3291076A GB 1530667 A GB1530667 A GB 1530667A
Authority
GB
United Kingdom
Prior art keywords
formula
substituted
argininamides
reacting
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32910/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9641775A external-priority patent/JPS5941991B2/en
Priority claimed from JP50106139A external-priority patent/JPS5913500B2/en
Priority claimed from JP50110242A external-priority patent/JPS5913501B2/en
Priority claimed from JP11852575A external-priority patent/JPS5913503B2/en
Priority claimed from JP12117375A external-priority patent/JPS5822030B2/en
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Publication of GB1530667A publication Critical patent/GB1530667A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/24—[b,e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

N<2>-Substituted L-arginine esters of the formula I in which the symbols have the meaning stated in the claim are highly specific thrombin inhibitors. They are suitable for the treatment or prophylaxis of thrombophilic diatheses. The compounds of the formula I are prepared by a) reacting compounds of the formula II with alcohols R-H in the presence of an acid catalyst, or b) reacting a compound of the formula II with an alcohol R-H and with a thionyl halide and, where appropriate, converting the resulting compound into a salt with an acid. <IMAGE>
GB32910/76A 1975-08-08 1976-08-06 N2-substituted argininamides Expired GB1530667A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP9641775A JPS5941991B2 (en) 1975-08-08 1975-08-08 Method for producing N↑2-substituted arginine amides or acid addition salts thereof
JP50106139A JPS5913500B2 (en) 1975-09-02 1975-09-02 Method for producing N↑2-naphthalenesulfonylargininamides or acid addition salts thereof
JP50110242A JPS5913501B2 (en) 1975-09-11 1975-09-11 Method for producing N↑2-naphthalenesulfonylargininamides or acid addition salts thereof
JP11852575A JPS5913503B2 (en) 1975-10-01 1975-10-01 Method for producing N↑2-naphthalenesulfonylarginine esters or amides or acid addition salts thereof
JP12117375A JPS5822030B2 (en) 1975-10-07 1975-10-07 N2- Naphthalene sulfonyl arginine ester

Publications (1)

Publication Number Publication Date
GB1530667A true GB1530667A (en) 1978-11-01

Family

ID=27525790

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32910/76A Expired GB1530667A (en) 1975-08-08 1976-08-06 N2-substituted argininamides

Country Status (9)

Country Link
CA (1) CA1106851A (en)
CH (3) CH632243A5 (en)
DE (1) DE2635548C2 (en)
DK (1) DK357876A (en)
FR (1) FR2320088A1 (en)
GB (1) GB1530667A (en)
NL (1) NL7608784A (en)
NO (1) NO762744L (en)
SE (1) SE428014B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9504350D0 (en) * 1995-03-04 1995-04-26 Sod Conseils Rech Applic Arginine derivatives

Also Published As

Publication number Publication date
NO762744L (en) 1977-02-09
NL7608784A (en) 1977-02-10
CH629764A5 (en) 1982-05-14
FR2320088B1 (en) 1978-12-22
SE428014B (en) 1983-05-30
DE2635548C2 (en) 1985-05-23
DE2635548A1 (en) 1977-03-03
DK357876A (en) 1977-02-09
SE7608791L (en) 1977-02-09
FR2320088A1 (en) 1977-03-04
CH632243A5 (en) 1982-09-30
CA1106851A (en) 1981-08-11
CH628880A5 (en) 1982-03-31

Similar Documents

Publication Publication Date Title
GEP19960242B (en) Method for Production of Derivatives of Benzohydrilsulfinyl or its Salts
JPS57108073A (en) N-substituted omega-(2-oxo-4-imidazoline- 1-yl)alkanoic acid compound
FR2222097A1 (en)
GB1530667A (en) N2-substituted argininamides
SE7509107L (en) ARYLOXY OR ARYLTIO CONTAINING SECOPROSTAGLANDINS
GR37361B (en) METHOD FOR THE MANUFACTURE OF DIARYLOCYCLOPROPANE PRODUCERS.
ES396221A1 (en) Phosphorus-containing unsaturated carboxylic acid derivatives
JPS523046A (en) Prepration of 4-homotwistane-3-carboxylic acid esters
CH608785A5 (en) Process for producing new N-acylglutamines
GB1513631A (en) Piperidine derivatives
SE7701834L (en) 4-HYDROXY-2-QUINOLINONE-3-CARBOXYLIC ACID ESTERS
ES446187A1 (en) Oxime ethers having anti-depressive activity
ES385183A1 (en) Beta-(2,4,6-triiodo-3-acetamidinophenyl)-propionic acids
ES413579A1 (en) Process for making 2-quinoxalinecarboxamide-1,4-dioxides
SE7601714L (en) SUBSTITUTED INDANYLPROPION ACIDS
ES427869A1 (en) 5-phenyl-sulphinyl-2-benzimidazolyl-carbamic acid esters and process for their manufacture
ES390952A1 (en) Procedure for the preparation of 2-piperidilcarbinols. (Machine-translation by Google Translate, not legally binding)
GB1063364A (en) Oxazine compounds and the preparation thereof
GB1457086A (en) Alkanolamine derivatives
ES446239A1 (en) 8-azaprostaglandins and process for the preparation thereof
ES8101601A1 (en) A procedure for the preparation of a penicilline (Machine-translation by Google Translate, not legally binding)
CH613203A5 (en) Process for the preparation of 4,4-diphenylcyclohexylpiperidine
ES437880A1 (en) Procedure for obtaining a benzamidic derivative. (Machine-translation by Google Translate, not legally binding)
ES438996A1 (en) Procedure for the obtaining of a substitute derivative of dean. (Machine-translation by Google Translate, not legally binding)
ES269484A1 (en) Procedure for the obtaining of thioesters with alkyl long chain compounds (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee