SE7506327L - PROCEDURE FOR THE PREPARATION OF 8-THIOMETHYLERGOLINS - Google Patents

PROCEDURE FOR THE PREPARATION OF 8-THIOMETHYLERGOLINS

Info

Publication number
SE7506327L
SE7506327L SE7506327A SE7506327A SE7506327L SE 7506327 L SE7506327 L SE 7506327L SE 7506327 A SE7506327 A SE 7506327A SE 7506327 A SE7506327 A SE 7506327A SE 7506327 L SE7506327 L SE 7506327L
Authority
SE
Sweden
Prior art keywords
compound
coalk
alk
june
reacting
Prior art date
Application number
SE7506327A
Other languages
Swedish (sv)
Other versions
SE420095B (en
Inventor
E C Kornfeld
N J Bach
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SE7506327L publication Critical patent/SE7506327L/en
Publication of SE420095B publication Critical patent/SE420095B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

1505296 8-Thiomethylergoline derivatives ELI LILLY & CO 3 June 1975 [6 June 1974] 23869/75 Heading C2C Novel compounds of the Formula II wherein R is H, CN, COalk, phenyl or alk; R<SP>1</SP> is H, Cl or Br; alk is C 1-3 alkyl and the dotted line is an optical bond and pharmaceuticallyacceptable acid addition salts thereof, may be prepared by reacting a compound of the Formula III wherein R 2 is methanesulphonyl or p-toluene sulphonyl with an alkali metal salt of a compound R<SP>3</SP>5H, wherein R<SP>3</SP> is CN, COalk, phenyl or alk, optionally followed where R<SP>3</SP> is -COalk by hydrolysis to produce a compound II in which R is H. D - 6 - Methyl - 8 - mesyloxymethylergoline and its 9,10-didehydro derivative are prepared by reacting the corresponding 8-hydroxymethyl compound with methane sulphonyl chloride. Pharmaceutical compositions of the compounds II with the usual excipients are prolactin inhibitors when administered parenterally.
SE7506327A 1974-06-06 1975-06-03 ANALOGY PROCEDURE FOR PREPARATION OF 8-THIOMETHYL ERGOLINES SE420095B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US477136A US3901894A (en) 1974-06-06 1974-06-06 8-thiomethylergolines

Publications (2)

Publication Number Publication Date
SE7506327L true SE7506327L (en) 1975-12-08
SE420095B SE420095B (en) 1981-09-14

Family

ID=23894677

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7506327A SE420095B (en) 1974-06-06 1975-06-03 ANALOGY PROCEDURE FOR PREPARATION OF 8-THIOMETHYL ERGOLINES

Country Status (27)

Country Link
US (1) US3901894A (en)
JP (1) JPS582946B2 (en)
AR (1) AR210736A1 (en)
AT (1) AT344333B (en)
AU (1) AU507574B2 (en)
BE (1) BE829887A (en)
BG (1) BG24812A3 (en)
CA (1) CA1071623A (en)
CH (1) CH617196A5 (en)
CS (1) CS199591B2 (en)
DD (1) DD120438A5 (en)
DE (1) DE2524575A1 (en)
DK (1) DK144160C (en)
ES (1) ES438313A1 (en)
FR (1) FR2273542A1 (en)
GB (1) GB1505296A (en)
HU (1) HU173590B (en)
IE (1) IE41474B1 (en)
IL (1) IL47424A (en)
NL (1) NL180911C (en)
PH (1) PH10992A (en)
PL (1) PL95738B1 (en)
RO (1) RO77543A (en)
SE (1) SE420095B (en)
SU (1) SU613724A3 (en)
YU (1) YU145575A (en)
ZA (1) ZA753638B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147789A (en) * 1974-03-14 1979-04-03 Sandoz Ltd. 6-Methyl-8-thiomethyl-ergolene derivatives
US3959288A (en) * 1974-12-13 1976-05-25 Eli Lilly And Company 8-Oxymethylergolines and process therefor
JPS5283894A (en) * 1976-01-01 1977-07-13 Lilly Co Eli 88thiomethyl ergoline
GB1549829A (en) * 1976-05-26 1979-08-08 Farmaceutici Italia 10'-methoxy-1',6'-dimethylergoline-8'-beta-methyl-amino(or thio)-pyrazines
IT1192260B (en) * 1977-07-05 1988-03-31 Simes ERGOLINE-2-THIOETHERS AND THEIR SULPHOXIDES DERIVATIVES
US4180582A (en) * 1978-02-08 1979-12-25 Eli Lilly And Company 6-n-Propyl-8-methoxy-methyl or methylmercaptomethylergolines and related compounds as prolactin inhibitors and to treat Parkinson's syndrome
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4202979A (en) * 1979-01-11 1980-05-13 Eli Lilly And Company 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3216870A1 (en) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen PHARMACEUTICAL PREPARATIONS WITH A CYTOSTATIC EFFECT
FR2526797A1 (en) * 1982-05-12 1983-11-18 Roussel Uclaf NOVEL 9-OXALYSERGIC ACID DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
CH649998A5 (en) * 1982-08-09 1985-06-28 Sandoz Ag ERGOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND HEALING AGENTS, CONTAINING THESE ERGOL DERIVATIVES AS AN ACTIVE SUBSTANCE.
GB8427536D0 (en) * 1984-10-31 1984-12-05 Lilly Industries Ltd Ergoline derivatives
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
FR2589734B1 (en) * 1985-11-13 1988-09-02 Roussel Uclaf USE OF ERGOLIN DERIVATIVES FOR OBTAINING A GERIATRIC MEDICINE
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
KR100754917B1 (en) 2001-06-08 2007-09-04 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. Somatostatin-dopamine chimeric analogs
EP1485382B1 (en) * 2002-03-15 2008-11-19 Antibioticos S.p.A. Process for the synthesis of pergolide
TWI523863B (en) 2012-11-01 2016-03-01 艾普森藥品公司 Somatostatin-dopamine chimeric analogs
RU2015120570A (en) 2012-11-01 2016-12-20 Ипсен Фарма С.А.С. SOMATOSTATIN ANALOGUES AND THEIR DIMERS
US20190374534A1 (en) 2018-06-08 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507248A (en) * 1967-03-16 1971-05-15 Spofa Vereinigte Pharma Werke Process for the preparation of D-6-methylergolin (I) ylacetic acid
DE1935556A1 (en) * 1969-07-12 1971-01-21 Hoechst Ag Process for the production of lysergol
JPS5012398A (en) * 1973-06-08 1975-02-07

Also Published As

Publication number Publication date
SU613724A3 (en) 1978-06-30
ES438313A1 (en) 1977-05-16
YU145575A (en) 1982-02-28
SE420095B (en) 1981-09-14
JPS50160300A (en) 1975-12-25
DE2524575A1 (en) 1975-12-18
IL47424A0 (en) 1975-08-31
BE829887A (en) 1975-12-05
ZA753638B (en) 1977-01-26
IE41474B1 (en) 1980-01-16
PH10992A (en) 1977-10-20
DD120438A5 (en) 1976-06-12
CA1071623A (en) 1980-02-12
CH617196A5 (en) 1980-05-14
AR210736A1 (en) 1977-09-15
AU507574B2 (en) 1980-02-21
AT344333B (en) 1978-07-10
IE41474L (en) 1975-12-06
NL180911C (en) 1987-05-18
FR2273542A1 (en) 1976-01-02
RO77543A (en) 1982-02-26
PL95738B1 (en) 1977-11-30
NL180911B (en) 1986-12-16
DK144160C (en) 1982-06-07
FR2273542B1 (en) 1978-10-06
ATA427975A (en) 1977-11-15
BG24812A3 (en) 1978-05-12
DK249975A (en) 1975-12-07
JPS582946B2 (en) 1983-01-19
US3901894A (en) 1975-08-26
IL47424A (en) 1979-11-30
HU173590B (en) 1979-06-28
NL7506584A (en) 1975-12-09
CS199591B2 (en) 1980-07-31
AU8182775A (en) 1976-12-09
DK144160B (en) 1981-12-28
GB1505296A (en) 1978-03-30

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