SE464135B - Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov - Google Patents

Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov

Info

Publication number
SE464135B
SE464135B SE8902532A SE8902532A SE464135B SE 464135 B SE464135 B SE 464135B SE 8902532 A SE8902532 A SE 8902532A SE 8902532 A SE8902532 A SE 8902532A SE 464135 B SE464135 B SE 464135B
Authority
SE
Sweden
Prior art keywords
protein
thrombin
coagulation
plasma
fixa
Prior art date
Application number
SE8902532A
Other languages
English (en)
Swedish (sv)
Other versions
SE8902532L (sv
SE8902532D0 (sv
Inventor
S Rosen
Original Assignee
Kabivitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab
Priority to SE8902532A priority Critical patent/SE464135B/sv
Publication of SE8902532D0 publication Critical patent/SE8902532D0/xx
Priority to CA002063564A priority patent/CA2063564A1/en
Priority to AT90910954T priority patent/ATE127853T1/de
Priority to AU60533/90A priority patent/AU6053390A/en
Priority to IE243190A priority patent/IE902431A1/en
Priority to EP90910954A priority patent/EP0486515B1/en
Priority to ES90910954T priority patent/ES2079481T3/es
Priority to DE69022425T priority patent/DE69022425T2/de
Priority to JP2510438A priority patent/JP2892828B2/ja
Priority to US07/793,342 priority patent/US5439802A/en
Priority to DK90910954.8T priority patent/DK0486515T3/da
Priority to PCT/SE1990/000478 priority patent/WO1991001382A1/en
Publication of SE8902532L publication Critical patent/SE8902532L/
Publication of SE464135B publication Critical patent/SE464135B/sv
Priority to NO920125A priority patent/NO920125D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
    • G01N2333/4613—Snake venom
    • G01N2333/462—Snake venom from Agkistrodon sp., e.g. acutase, ACTE
    • G01N2333/4626—Snake venom from Agkistrodon sp., e.g. acutase, ACTE from Agkistrodon contortrix contortrix (copperhead snake); Protac (R)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/9645—Factor IX (3.4.21.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96461—Protein C (3.4.21.69)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE8902532A 1989-07-14 1989-07-14 Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov SE464135B (sv)

Priority Applications (13)

Application Number Priority Date Filing Date Title
SE8902532A SE464135B (sv) 1989-07-14 1989-07-14 Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov
PCT/SE1990/000478 WO1991001382A1 (en) 1989-07-14 1990-07-04 A method for determining the functional activity of free protein s or protein c in a plasma sample
ES90910954T ES2079481T3 (es) 1989-07-14 1990-07-04 Un procedimiento para la determinacion de la actividad funcional de la proteina s o de la proteina c libre en una muestra de plasma.
JP2510438A JP2892828B2 (ja) 1989-07-14 1990-07-04 血漿プロテインの検定方法
AU60533/90A AU6053390A (en) 1989-07-14 1990-07-04 A method for determining the functional activity of free protein s or protein c in a plasma sample
IE243190A IE902431A1 (en) 1989-07-14 1990-07-04 Assaying of plasma proteins
EP90910954A EP0486515B1 (en) 1989-07-14 1990-07-04 A method for determining the functional activity of free protein S or protein C in a plasma sample
CA002063564A CA2063564A1 (en) 1989-07-14 1990-07-04 Method for determining the functional activity of free protein s or protein c in a plasma sample
DE69022425T DE69022425T2 (de) 1989-07-14 1990-07-04 Verfahren zur Bestimmung der funktionellen Wirkung von freiem Protein S oder Protein C in einer Plasmaprobe.
AT90910954T ATE127853T1 (de) 1989-07-14 1990-07-04 Verfahren zur bestimmung der funktionellen wirkung von freiem protein s oder protein c in einer plasmaprobe.
US07/793,342 US5439802A (en) 1989-07-14 1990-07-04 Method for determining the functional activity of free protein S or protein C in a plasma sample
DK90910954.8T DK0486515T3 (da) 1989-07-14 1990-07-04 Fremgangsmåde til bestemmelse af den funktionelle aktivitet af frit protein S eller protein C i en plasmaprøve
NO920125A NO920125D0 (no) 1989-07-14 1992-01-09 Fremgangsmaate for aa bestemme den funksjonelle aktivitetentil fri protein s eller protein c i en plasma-proeve

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8902532A SE464135B (sv) 1989-07-14 1989-07-14 Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov

Publications (3)

Publication Number Publication Date
SE8902532D0 SE8902532D0 (sv) 1989-07-14
SE8902532L SE8902532L (sv) 1991-01-15
SE464135B true SE464135B (sv) 1991-03-11

Family

ID=20376547

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8902532A SE464135B (sv) 1989-07-14 1989-07-14 Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov

Country Status (13)

Country Link
US (1) US5439802A (es)
EP (1) EP0486515B1 (es)
JP (1) JP2892828B2 (es)
AT (1) ATE127853T1 (es)
AU (1) AU6053390A (es)
CA (1) CA2063564A1 (es)
DE (1) DE69022425T2 (es)
DK (1) DK0486515T3 (es)
ES (1) ES2079481T3 (es)
IE (1) IE902431A1 (es)
NO (1) NO920125D0 (es)
SE (1) SE464135B (es)
WO (1) WO1991001382A1 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010261A1 (en) * 1991-11-13 1993-05-27 Dahlbaeck Bjoern Method for the diagnosis of blood coagulation disorders
US5443960A (en) * 1991-11-13 1995-08-22 Dahlbaeck; Bjoern Method for the diagnosis of blood coagulation disorders
WO1996014581A1 (en) * 1994-11-08 1996-05-17 Global Hemostasis Institute Mgr Ab Method, reagent and kit for analysis of haemostatic activity
WO1998044000A1 (en) * 1997-04-03 1998-10-08 T.A.C. Thrombosis And Coagulation Aktiebolag Recombinant protein c and protein s variants

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4006634A1 (de) * 1990-03-03 1991-09-05 Behringwerke Ag Funktioneller test zur bestimmung der protein s-aktivitaet
AU2870992A (en) * 1991-10-04 1993-05-03 Board Of Regents Of The University Of Nebraska, The A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins
US5716795A (en) * 1991-10-04 1998-02-10 Matschiner; John T. Thrombomodulin-based coagulometric assay of the protein C system
AU663343B2 (en) * 1991-10-04 1995-10-05 Dade Behring Inc. Preparation of prothrombin time reagents from recombinant human tissue factor and purified natural and synthetic phospholipids
US5308756A (en) * 1991-11-20 1994-05-03 Baxter Diagnostics Inc. Protein S chromogenic assay
DE4229933A1 (de) * 1992-09-08 1994-03-10 Max Planck Gesellschaft Verfahren zur Bestimmung von Thrombose verursachenden Lupus-anticoagulant-Antikörpern
HUT72191A (en) * 1993-01-29 1996-03-28 Dahlbaeck Novel anticoagulant cofactor activity
ATE213023T1 (de) * 1993-12-03 2002-02-15 Baxter Ag Test zur bestimmung der empfindlichkeit gegenüber aktiviertem protein c
AUPM731394A0 (en) * 1994-08-05 1994-09-01 Life Therapeutics Limited Improved activated protein c resistance test
DE4427785A1 (de) * 1994-08-08 1996-02-15 Behringwerke Ag Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems
US5780255A (en) * 1995-06-09 1998-07-14 Instrumentation Laboratory, S.P.A. Protein C pathway screening test
US5766869A (en) * 1995-11-30 1998-06-16 Ahs Hospital Corp. Factor V ratio blood test for susceptibility to thromboembolism
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
AUPP159698A0 (en) * 1998-02-02 1998-02-26 Life Therapeutics Limited Improved blood coagulation test
PT947585E (pt) 1998-03-19 2001-11-30 Instrumentation Lab Spa Metodo in vitro melhorado, kits e reagentes para a peaquisa de defeitos de coagulacao sanguinea
US6855509B2 (en) 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
JP5839256B2 (ja) 2011-03-14 2016-01-06 学校法人九州文化学園 総プロテインｓ異常症の検出方法において用いる試薬
CN106153612A (zh) * 2015-12-04 2016-11-23 上海贞元诊断用品科技有限公司 抗凝血酶活性检测试剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
DE3516579A1 (de) * 1984-11-19 1986-05-22 Boehringer Mannheim Gmbh, 6800 Mannheim Gerinnungstest auf teststreifen
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
DE3607559A1 (de) * 1986-03-07 1987-09-10 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet
US4908314A (en) * 1987-07-02 1990-03-13 American National Red Cross Protein C activator
DE3724443A1 (de) * 1987-07-23 1989-02-02 Max Planck Gesellschaft Funktioneller test zur bestimmung der protein s-aktivitaet
JP2739050B2 (ja) * 1988-01-28 1998-04-08 ヘキスト薬品工業株式会社 抗血液凝固剤
US5051357A (en) * 1989-07-14 1991-09-24 Board Of Trustees Operating Michigan State University Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010261A1 (en) * 1991-11-13 1993-05-27 Dahlbaeck Bjoern Method for the diagnosis of blood coagulation disorders
US5443960A (en) * 1991-11-13 1995-08-22 Dahlbaeck; Bjoern Method for the diagnosis of blood coagulation disorders
WO1996014581A1 (en) * 1994-11-08 1996-05-17 Global Hemostasis Institute Mgr Ab Method, reagent and kit for analysis of haemostatic activity
US6156530A (en) * 1994-11-08 2000-12-05 Global Hemostasis Institute Mgr Ab Method for analysis of haemostatic activity
WO1998044000A1 (en) * 1997-04-03 1998-10-08 T.A.C. Thrombosis And Coagulation Aktiebolag Recombinant protein c and protein s variants

Also Published As

Publication number Publication date
DE69022425T2 (de) 1996-05-02
EP0486515A1 (en) 1992-05-27
NO920125L (no) 1992-01-09
JP2892828B2 (ja) 1999-05-17
ATE127853T1 (de) 1995-09-15
US5439802A (en) 1995-08-08
NO920125D0 (no) 1992-01-09
SE8902532L (sv) 1991-01-15
ES2079481T3 (es) 1996-01-16
JPH04506603A (ja) 1992-11-19
IE902431A1 (en) 1991-06-19
SE8902532D0 (sv) 1989-07-14
DE69022425D1 (de) 1995-10-19
AU6053390A (en) 1991-02-22
WO1991001382A1 (en) 1991-02-07
DK0486515T3 (da) 1996-01-29
CA2063564A1 (en) 1991-01-15
EP0486515B1 (en) 1995-09-13

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