SE455160B - Stabil perfluorkemisk emulsion for artificiellt blod samt forfarande for framstellning av en sadan - Google Patents

Stabil perfluorkemisk emulsion for artificiellt blod samt forfarande for framstellning av en sadan

Info

Publication number
SE455160B
SE455160B SE8304143A SE8304143A SE455160B SE 455160 B SE455160 B SE 455160B SE 8304143 A SE8304143 A SE 8304143A SE 8304143 A SE8304143 A SE 8304143A SE 455160 B SE455160 B SE 455160B
Authority
SE
Sweden
Prior art keywords
emulsion
lipid
perfluoro compound
particles
lecithin
Prior art date
Application number
SE8304143A
Other languages
English (en)
Swedish (sv)
Other versions
SE8304143D0 (sv
SE8304143L (sv
Inventor
H A Sloviter
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of SE8304143D0 publication Critical patent/SE8304143D0/xx
Publication of SE8304143L publication Critical patent/SE8304143L/xx
Publication of SE455160B publication Critical patent/SE455160B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE8304143A 1982-07-27 1983-07-26 Stabil perfluorkemisk emulsion for artificiellt blod samt forfarande for framstellning av en sadan SE455160B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/402,451 US4423077A (en) 1982-07-27 1982-07-27 Perfluorochemical emulsion artificial blood

Publications (3)

Publication Number Publication Date
SE8304143D0 SE8304143D0 (sv) 1983-07-26
SE8304143L SE8304143L (sv) 1984-01-28
SE455160B true SE455160B (sv) 1988-06-27

Family

ID=23591933

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8304143A SE455160B (sv) 1982-07-27 1983-07-26 Stabil perfluorkemisk emulsion for artificiellt blod samt forfarande for framstellning av en sadan

Country Status (7)

Country Link
US (1) US4423077A (de)
JP (1) JPS5946214A (de)
CA (1) CA1216519A (de)
DE (1) DE3326901A1 (de)
FR (1) FR2530953B1 (de)
GB (1) GB2124104B (de)
SE (1) SE455160B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795423A (en) * 1980-04-14 1989-01-03 Thomas Jefferson University Oxygenated perfluorinated perfusion of the ocular globe to treat ischemic retinopathy
US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4830849A (en) * 1980-04-14 1989-05-16 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4758431A (en) * 1980-04-14 1988-07-19 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4840617A (en) * 1980-04-14 1989-06-20 Thomas Jefferson University Cerebral and lumbar perfusion catheterization apparatus for use in treating hypoxic/ischemic neurologic tissue
US4530936A (en) * 1983-07-08 1985-07-23 Farmacon Research Corporation Composition and method for inhibiting the absorption of nutritional elements from the upper intestinal tract
SE8505048L (sv) * 1985-10-25 1987-04-26 Nutritional Int Res Inst Nutritionsemulsion med syretransporterande egenskaper
US5077036A (en) * 1986-01-14 1991-12-31 Alliance Pharmaceutical Corp. Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US5684050A (en) * 1986-01-24 1997-11-04 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
US5514720A (en) * 1986-07-09 1996-05-07 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
EP0257758B1 (de) * 1986-08-07 1993-03-10 Minnesota Mining And Manufacturing Company Stabile, biologisch-aktive, fluorchemische Emulsionen
US4895876A (en) * 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides
US4866096A (en) * 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
US4956390A (en) * 1987-08-25 1990-09-11 Air Products And Chemicals, Inc. Gas transport employing perfluorobutyldecalin
WO1989008459A1 (en) * 1988-03-11 1989-09-21 Alpha Therapeutic Corporation Perfluorochemical emulsion with stabilized vesicles
US5061484A (en) * 1988-03-11 1991-10-29 Alpha Therapeutic Corporation Perfluorochemical emulsion with stabilized vesicles
US5171755A (en) * 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US5073383A (en) * 1989-04-21 1991-12-17 Affinity Biotech, Inc. Inhibiting aggregation in fluorocarbon emulsions
WO1991000110A1 (en) * 1989-07-05 1991-01-10 Alliance Pharmaceutical Corp. Fluorocarbon emulsions having saturated phospholipid emulsifiers
US5146014A (en) * 1991-07-02 1992-09-08 Air Products And Chemicals, Inc. Perfluoroethyldimethyl cyclohexane
US5304325A (en) * 1991-11-13 1994-04-19 Hemagen/Pfc Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
US5403575A (en) * 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
US5595687A (en) * 1992-10-30 1997-01-21 Thomas Jefferson University Emulsion stability
DE4308312A1 (de) * 1993-03-16 1994-09-22 Fresenius Ag Kardioplegische Emulsion
FR2710840B1 (fr) * 1993-10-04 1995-12-01 Applic Transferts Technolo Compositions viscoélastiques hautement concentrées en composés fluorés, leur préparation et leurs utilisations dans le domaine médical et en cosmétique.
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US5658962A (en) 1994-05-20 1997-08-19 Minnesota Mining And Manufacturing Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US5614170A (en) * 1994-11-30 1997-03-25 Hemagen/Pfc Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
US5843024A (en) 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US6679859B1 (en) 1997-10-24 2004-01-20 Alliance Pharmaceutical Corp. Amelioration of ischemic damage using synthetic oxygen carriers
US20070026024A1 (en) * 2005-07-27 2007-02-01 Drees Thomas C Compositions and methods for emulsifying a pefluorocarbon with an oxygen-carrying surfactant
US9700523B2 (en) 2011-10-13 2017-07-11 Nuvox Pharma Llc Buffered oxygen therapeutic
US8822549B2 (en) * 2011-10-13 2014-09-02 Jennifer L. Johnson Buffered oxygen therapeutic
WO2024046999A1 (de) * 2022-08-31 2024-03-07 Johann Wolfgang Goethe-Universität Frankfurt am Main Lecithin-modifizierte nanoskalierte sauerstoffträger (lenox)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH604490A5 (de) * 1970-09-05 1978-09-15 Green Cross Corp
US3958014A (en) * 1970-09-05 1976-05-18 The Green Cross Corporation Process for preparing injection-purpose fluorocarbon emulsion capable of carrying oxygen
JPS5331209B2 (de) * 1973-10-05 1978-09-01
JPS5835485B2 (ja) * 1976-02-03 1983-08-03 株式会社ミドリ十字 酸素運搬輸液
GB1578776A (en) * 1976-06-10 1980-11-12 Univ Illinois Hemoglobin liposome and method of making the same
US4105798A (en) * 1976-07-19 1978-08-08 Sun Ventures, Inc. Perfluoro polycyclic compounds for use as synthetic blood and perfusion media
JPS55118415A (en) * 1979-02-28 1980-09-11 Pii Papahadojiyopo Dometoriosu Method of encapsulating biologically active substance in lipoid cell
US4252827A (en) * 1979-05-23 1981-02-24 The Green Cross Corporation Oxygen-transferable fluorocarbon emulsion
CA1181011A (en) * 1980-05-27 1985-01-15 Robert P. Geyer Perfluorinated n,n-dimethyl cyclohexylmethylamine and emulsions containing the same
JPS5782311A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation
US4569784A (en) * 1980-11-17 1986-02-11 Adamantech, Inc. Preparation of a gel having gas transporting capability

Also Published As

Publication number Publication date
DE3326901C2 (de) 1989-09-21
JPS5946214A (ja) 1984-03-15
SE8304143D0 (sv) 1983-07-26
FR2530953A1 (fr) 1984-02-03
GB2124104A (en) 1984-02-15
US4423077A (en) 1983-12-27
DE3326901A1 (de) 1984-02-16
GB8318539D0 (en) 1983-08-10
CA1216519A (en) 1987-01-13
SE8304143L (sv) 1984-01-28
GB2124104B (en) 1986-02-05
FR2530953B1 (fr) 1986-08-29

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