SE444933B - Lekemedel for behandling av sjukdomar i centrala nervsystemet, vilka innehaller vissa cyklohexylkarboxylsyraderivat som aktiv bestandsdel - Google Patents

Lekemedel for behandling av sjukdomar i centrala nervsystemet, vilka innehaller vissa cyklohexylkarboxylsyraderivat som aktiv bestandsdel

Info

Publication number
SE444933B
SE444933B SE7903687A SE7903687A SE444933B SE 444933 B SE444933 B SE 444933B SE 7903687 A SE7903687 A SE 7903687A SE 7903687 A SE7903687 A SE 7903687A SE 444933 B SE444933 B SE 444933B
Authority
SE
Sweden
Prior art keywords
acid
cyclohexyl
group
mixture
yield
Prior art date
Application number
SE7903687A
Other languages
English (en)
Swedish (sv)
Other versions
SE7903687L (sv
Inventor
C Pigerol
J-C Vernieres
P Eymard
J Simiand
M Broll
J-Y Lacolle
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SE7903687L publication Critical patent/SE7903687L/xx
Publication of SE444933B publication Critical patent/SE444933B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/27—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with oxides of nitrogen or nitrogen-containing mineral acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/15—Saturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/02—Saturated compounds containing hydroxy or O-metal groups
    • C07C62/04—Saturated compounds containing hydroxy or O-metal groups with a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
    • C07C62/10—Saturated compounds containing ether groups, groups, groups, or groups with a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/18—Saturated compounds containing keto groups
    • C07C62/20—Saturated compounds containing keto groups with a saturated six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE7903687A 1978-04-27 1979-04-26 Lekemedel for behandling av sjukdomar i centrala nervsystemet, vilka innehaller vissa cyklohexylkarboxylsyraderivat som aktiv bestandsdel SE444933B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1676278 1978-04-27

Publications (2)

Publication Number Publication Date
SE7903687L SE7903687L (sv) 1979-10-28
SE444933B true SE444933B (sv) 1986-05-20

Family

ID=10083194

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7903687A SE444933B (sv) 1978-04-27 1979-04-26 Lekemedel for behandling av sjukdomar i centrala nervsystemet, vilka innehaller vissa cyklohexylkarboxylsyraderivat som aktiv bestandsdel
SE8304410A SE8304410L (sv) 1978-04-27 1983-08-15 Cyklohexylkarboxylsyraderivat och sett for deras framstellning

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8304410A SE8304410L (sv) 1978-04-27 1983-08-15 Cyklohexylkarboxylsyraderivat och sett for deras framstellning

Country Status (15)

Country Link
US (1) US4283420A (it)
JP (1) JPS6054285B2 (it)
BE (1) BE875882A (it)
CA (1) CA1150150A (it)
CH (1) CH641756A5 (it)
DE (1) DE2916588A1 (it)
DK (1) DK168079A (it)
ES (1) ES480041A1 (it)
FR (1) FR2432015A1 (it)
GB (2) GB2023002B (it)
IT (1) IT1202916B (it)
NL (1) NL7903352A (it)
OA (1) OA06248A (it)
SE (2) SE444933B (it)
YU (1) YU102579A (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675342A (en) * 1979-02-02 1987-06-23 The United States Of America As Represented By The Secretary Of Agriculture Cockroach repellents
US4530935A (en) * 1979-02-02 1985-07-23 The United States Of America As Represented By The Secretary Of Agriculture Insect repellents
US5068414A (en) * 1990-01-26 1991-11-26 Celgene Corporation Hydroxyterephthalic acid
US5086054A (en) * 1990-07-31 1992-02-04 Sri International Novel arylcycloalkanepolyalkylamines
EP1935867A1 (en) * 2006-12-20 2008-06-25 F. Hoffmann-La Roche Ag Process for preparing 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid
BRPI0911170B1 (pt) * 2008-04-04 2018-05-29 F. Hoffmann-La Roche Ag Processo para a preparação de derivados do ácido ciclo-hexanocarboxílico via o correpondente derivado de ciclo-hexanocarboxamida
ES2592727T3 (es) * 2008-04-04 2016-12-01 F. Hoffmann-La Roche Ag Nuevo proceso para la preparación de derivados del ácido ciclohexanocarboxílico
CN102015629A (zh) * 2008-05-08 2011-04-13 弗·哈夫曼-拉罗切有限公司 1-(2-乙基丁基)环己腈的合成方法
GB201416017D0 (en) * 2014-09-10 2014-10-22 New Royal Holloway & Bedford An Anticonvulsant Compound

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL62140C (it) * 1942-12-16
US2474796A (en) * 1946-01-31 1949-06-28 Wm S Merrell Co Alkylaminoalkyl esters of alicyclyl-alicyclic carboxylic acids
US2688025A (en) * 1952-02-12 1954-08-31 Olin Mathieson Basic derivatives of substituted cycloalkanecarboxylic acids and methods of preparing same
US2757177A (en) * 1952-02-12 1956-07-31 Olin Mathieson Basic derivatives of substituted cycloalkanecarboxylic acids and methods of preparing same
DE1048575B (de) * 1957-04-27 1959-01-15 Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M Verfahren zur Herstellung von Cyclohexencarbonsäureamiden
FR1231163A (fr) * 1959-04-08 1960-09-27 Kodak Pathe Nouveaux polyesters de grande masse moléculaire, procédé et intermédiaires pour leur fabrication et leurs applications industrielles
DE1301811B (de) * 1964-05-22 1969-08-28 E.I. Du Pont De Nemours And Company, Wilmington, Del. (V.St.A.) Verfahren zur Herstellung von 4-Alkyl-1,4-dimethylcyclohexylaminen bzw. -cyclohexylmethylaminen bzw. von deren Salzen
DE1933985A1 (de) * 1968-07-04 1970-01-15 Takeda Chemical Industries Ltd Neue Cycloalkancarbonsaeurederivate und Verfahren zu ihrer Herstellung
FR2059975A1 (en) * 1969-08-13 1971-06-11 Synthelabo 1-substd cyclohexane carboxylic acid hydrazides
US3841024A (en) * 1972-03-24 1974-10-15 Chiap Hua Comalco Ltd Sliding window
GB1411786A (en) * 1972-04-18 1975-10-29 Wilkinson Sword Ltd Substituted cyclohexanamides their preparation and use as cold receptor stimulants
IT1006572B (it) * 1972-04-18 1976-10-20 Wilkinson Sword Ltd Composizioni ingeribili locali e altre aventi un effetto fisiologi co raffreddante sulla pelle e sul le membrane mucose del corpo

Also Published As

Publication number Publication date
GB2081714A (en) 1982-02-24
JPS6054285B2 (ja) 1985-11-29
DE2916588A1 (de) 1979-11-08
DK168079A (da) 1979-10-28
CH641756A5 (fr) 1984-03-15
YU102579A (en) 1983-12-31
FR2432015B1 (it) 1984-11-16
SE8304410D0 (sv) 1983-08-15
IT7922191A0 (it) 1979-04-27
GB2081714B (en) 1983-03-23
NL7903352A (nl) 1979-10-30
SE7903687L (sv) 1979-10-28
JPS554365A (en) 1980-01-12
US4283420A (en) 1981-08-11
IT1202916B (it) 1989-02-15
ES480041A1 (es) 1980-07-16
BE875882A (fr) 1979-08-16
FR2432015A1 (fr) 1980-02-22
CA1150150A (en) 1983-07-19
SE8304410L (sv) 1983-08-15
GB2023002A (en) 1979-12-28
GB2023002B (en) 1982-11-24
OA06248A (fr) 1981-06-30

Similar Documents

Publication Publication Date Title
US3600437A (en) Substituted phenylalkanoic acids and derivatives thereof
JP2655692B2 (ja) スルホンアミドチエニルカルボン酸化合物
EP0257882B1 (en) N-phenyl butenamides with pharmaceutical properties
US2338220A (en) Process of making oxazolidinediones
SE444933B (sv) Lekemedel for behandling av sjukdomar i centrala nervsystemet, vilka innehaller vissa cyklohexylkarboxylsyraderivat som aktiv bestandsdel
EP0222996A2 (de) 3-Amino-dihydro-[1]-benzopyrane und Benzothiopyrane
EP0094595B1 (de) Neue Aziridin- und Phenäthanolaminderivate
EP0220573B1 (de) Heterocyclische Verbindungen
US3223712A (en) Synthesis of thioctic acid and thioctic acid amide
DE1620733A1 (de) Azetidinothiazolidinmethancarbonsaeureestern
Erhardt Curtius conversion of acids to amines under neutral conditions via an anthrylmethyl carbamate
US3931286A (en) Novel benzoylphenylacetic acid derivatives
Baker et al. BIOTIN. IV. A SECOND SYNTHESIS OF 2-(δ-CARBOXYBUTYL)-THIOPHANE-3, 4-DICARBOXYLIC ACID
US5135941A (en) LTB4 synthesis inhibitors
JPH01242577A (ja) 抗関節炎性イソキサゾール―４―カルボキシアミド
DE2251556C3 (de) Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4520028A (en) α-Aminobutyric acid transaminase inhibitors
US4169953A (en) Tricyclo[4.3.1.12,5 ]undecane-1-carboxylic acid and derivatives thereof and a process for producing the same
CH619955A5 (it)
US5179123A (en) LTB4 synthesis inhibitors
NZ208607A (en) Bicyclo(3.2.1)octane-3-carboxylic acid derivatives and therapeutic compositions
DE3121189A1 (de) "n-substituierte mercaptoacylpropionamide"
Dvoretzky et al. The synthesis of esters of 2, 6-dimethyl-4-aminobenzoic acid
Hanson et al. An expedient synthesis of (±)‐2‐amino‐3‐(3‐hydroxy‐5‐methylisoxazol‐4‐yl) propionic acid hydrobromide via a 3‐bromoisoxazole intermediate
US2821540A (en) Preparation of hindered 4-acylamido-benzoates

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7903687-7

Effective date: 19890427

Format of ref document f/p: F