SE414771B - Forfarande for framstellning av nya 11,11-alkyliden-steroider - Google Patents

Forfarande for framstellning av nya 11,11-alkyliden-steroider

Info

Publication number
SE414771B
SE414771B SE7316562A SE7316562A SE414771B SE 414771 B SE414771 B SE 414771B SE 7316562 A SE7316562 A SE 7316562A SE 7316562 A SE7316562 A SE 7316562A SE 414771 B SE414771 B SE 414771B
Authority
SE
Sweden
Prior art keywords
alkylideen
steroids
procedure
preparation
new
Prior art date
Application number
SE7316562A
Other languages
English (en)
Swedish (sv)
Inventor
Den Broek A J Van
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL7216767A external-priority patent/NL175063C/xx
Priority claimed from NL7315704A external-priority patent/NL7315704A/xx
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of SE414771B publication Critical patent/SE414771B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0092—Alkenyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
SE7316562A 1972-12-09 1973-12-07 Forfarande for framstellning av nya 11,11-alkyliden-steroider SE414771B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL7216767A NL175063C (nl) 1972-12-09 1972-12-09 Werkwijze ter bereiding van 11,11-alkylideensteroiden, werkwijze ter bereiding van farmaceutische preparaten en gevormde farmaceutische preparaten.
NL7315704A NL7315704A (en) 1973-11-15 1973-11-15 11,11-Alkylidene steroids - of the oestrane, pregnane and 19-norpregnane series

Publications (1)

Publication Number Publication Date
SE414771B true SE414771B (sv) 1980-08-18

Family

ID=26644839

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7316562A SE414771B (sv) 1972-12-09 1973-12-07 Forfarande for framstellning av nya 11,11-alkyliden-steroider

Country Status (14)

Country Link
US (1) US3927046A (xx)
JP (1) JPS5933600B2 (xx)
CA (1) CA1021318A (xx)
CH (1) CH614453A5 (xx)
DE (1) DE2361120C2 (xx)
DK (2) DK135047B (xx)
ES (1) ES421253A1 (xx)
FI (1) FI54128C (xx)
FR (1) FR2209577B1 (xx)
GB (1) GB1455270A (xx)
IE (1) IE38617B1 (xx)
IL (1) IL43762A (xx)
PH (1) PH11191A (xx)
SE (1) SE414771B (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL188581C (nl) * 1974-07-15 1992-08-03 Akzo Nv Werkwijze voor het bereiden van 11beta-hydroxy-18-alkylestraanverbindingen.
FR2377419A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 11b-substitues 1,3,5 (10) trieniques, leur procede de preparation et leur application comme medicament
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
NL7701384A (nl) * 1977-02-10 1978-08-14 Akzo Nv Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks.
DE2913381A1 (de) * 1979-03-30 1980-10-16 Schering Ag 11-methylensteroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3042529A1 (de) * 1980-11-07 1982-06-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen 11-methylen- (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)5(pfeil hoch) -steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
AU572589B2 (en) * 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
US4567000A (en) * 1984-08-31 1986-01-28 The Upjohn Company 11-Difluoromethylene steroids
JPS6161578U (xx) * 1984-09-27 1986-04-25
US5236913A (en) * 1985-07-24 1993-08-17 Akzo N.V. 11-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions
IE58562B1 (en) * 1985-07-24 1993-10-06 Akzo Nv Novel 11-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions
US4662065A (en) * 1986-05-22 1987-05-05 Battery Engineering, Inc. Method for dehydrating manganese dioxide
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
ZA94715B (en) * 1993-02-08 1994-10-24 Akzo Nv Steroids for treating menopausal complaints
DE4330727C2 (de) * 1993-09-10 1998-02-19 Jenapharm Gmbh Steroidzwischenprodukte und Verfahren zu ihrer Herstellung
DE4344462C2 (de) 1993-12-22 1996-02-01 Schering Ag Zusammensetzung für die Empfängnisverhütung
DE4413184A1 (de) * 1994-04-12 1995-10-19 Schering Ag 10,11-C¶3¶-überbrückte Steroide
DE19723390C1 (de) * 1997-06-04 1998-06-10 Jenapharm Gmbh 9alpha-Hydroxy-8alpha-estra-1,3,5(10)-triene und Verfahren zu deren Herstellung
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
US6054446A (en) * 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US20050143360A1 (en) * 2001-02-02 2005-06-30 Joel Krasnow Method of using a cyclooxygenase-2 inhibitor and sex steroids as a combination therapy for the treatment and prevention of dismenorrhea
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
ITMI20021755A1 (it) * 2002-08-02 2002-11-01 Poli Ind Chimica Spa Processo e nuovi intermedi per la preparazione di steroidi ad attivita' progestinica.
HUP0301332A3 (en) * 2003-05-14 2006-04-28 Richter Gedeon Vegyeszet New mono-and bismethylene steroid derivatives and process for their synthesis and pharmaceutical compositions containing them
CN101445542B (zh) * 2008-12-25 2010-12-29 北京市科益丰生物技术发展有限公司 一种去氧孕烯的制备方法
CN102964418B (zh) * 2010-06-25 2015-04-15 华润紫竹药业有限公司 去氧孕烯的制备工艺及其中间体化合物
CN101857624B (zh) * 2010-06-25 2012-12-12 北京紫竹药业有限公司 去氧孕烯的制备工艺及其中间体化合物
CN102532232A (zh) * 2010-12-27 2012-07-04 上海信谊药厂有限公司 去氧孕烯的制备方法
US20130123523A1 (en) * 2011-11-10 2013-05-16 Klaus Nickisch Methods for the preparation of etonogestrel and desogestrel
WO2013092668A1 (en) 2011-12-23 2013-06-27 Crystal Pharma, S.A.U. Process for alkynylating 16-substituted-17-keto steroids
US9464108B2 (en) 2012-03-15 2016-10-11 Merck Sharp & Dohme B.V. Combined synthesis route for desogestrel and etonogestrel
ITMI20121472A1 (it) 2012-09-04 2014-03-05 Ind Chimica Srl Processo per la preparazione di 11-metilen-18-metilestr-4-en-3,17-dione, utile come intermedio per la sintesi di molecole ad attivita' farmacologica
EP3865501A1 (en) 2016-03-03 2021-08-18 Crystal Pharma, S.A.U. New intermediates for the preparation of 11-methylene steroids
CN107082793B (zh) * 2017-06-16 2019-07-05 上海共拓医药化工有限公司 去氧孕烯重要中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB912036A (en) * 1960-06-23 1962-12-05 British Drug Houses Ltd 11-methylene-5ª--steroids
US3299108A (en) * 1965-10-18 1967-01-17 Searle & Co 17alpha-alkynyl/alkenyl-13beta-alkyl-11-alkylgona-1, 3, 5 (10)-triene-3, 17beta-diols, ethers and esters thereof and intermediates thereto
US3325520A (en) * 1965-12-08 1967-06-13 Searle & Co (optionally 17-hydrocarbon-substituted) 11, 13beta-dialkylgon-4-en-3-ones and esters corresponding
US3346602A (en) * 1966-10-12 1967-10-10 Searle & Co 13beta-alkyl-11-alkylgona-1, 3, 5 (10)-trien-17-ones, ethers and esters thereof
US3527778A (en) * 1969-02-27 1970-09-08 Searle & Co 3,17 - bisoxygenated 11betamethyl - 19 - norpregn - 4 - en - 20 - ones and derivatives thereof

Also Published As

Publication number Publication date
DK293776A (da) 1976-06-30
DK135047C (xx) 1977-07-25
ES421253A1 (es) 1976-07-16
FR2209577A1 (xx) 1974-07-05
GB1455270A (en) 1976-11-10
DE2361120A1 (de) 1974-06-12
DK135047B (da) 1977-02-28
IL43762A0 (en) 1974-03-14
FI54128C (fi) 1978-10-10
CA1021318A (en) 1977-11-22
PH11191A (en) 1977-10-28
JPS5029548A (xx) 1975-03-25
AU6326373A (en) 1975-06-05
FR2209577B1 (xx) 1977-06-03
US3927046A (en) 1975-12-16
DK147405B (da) 1984-07-23
DK147405C (da) 1985-02-04
FI54128B (fi) 1978-06-30
DE2361120C2 (de) 1984-01-19
JPS5933600B2 (ja) 1984-08-16
IL43762A (en) 1978-04-30
CH614453A5 (xx) 1979-11-30
IE38617B1 (en) 1978-04-26
IE38617L (en) 1974-06-09

Similar Documents

Publication Publication Date Title
SE414771B (sv) Forfarande for framstellning av nya 11,11-alkyliden-steroider
SE407579B (sv) Forfarande for framstellning av n-fosfonometylglycin
SE386445B (sv) Forfaranden for framstellning av nya bensotiadiazoler
NO140731C (no) Fremgangsmaate for fremstilling av dimetyleter
SE395149B (sv) Forfarande for framstellning av dibenso-tiepinylpiperazinderivat
SE424994B (sv) Forfarande for framstellning av nya pseudotrisackarider
SE416731B (sv) Forfarande for framstellning av nya penicilliner
SE401676B (sv) Forfarande for framstellning av dibensofuranderivat
SE382053B (sv) Forfarande for framstellning av bifenylylalkanoylaminopyridiner
SE383151B (sv) Forfarande for framstellning av 1-hydroxi-2-pyridoner
SE395460B (sv) Forfarande for framstellning av 2beta,16beta-dipiperidino-5alfa-androstaner
SE7602850L (sv) Forfarande for framstellning av nya steroider av pregnanserien
SE420716B (sv) Forfarande for framstellning av nya 2-aminometyl-4,6-diahalogenofenolderivat
SE400768B (sv) Forfarande for framstellning av 2-fenyl-6-sulfamoyl-7-klor-1,2,3,4-tetrahydro-4-kinazolinon
SE380272B (sv) Forfarande for framstellning av n-fosfonmetylglycin
SE393111B (sv) Forfarande for framstellning av d-2-halogen-6-metyl-8-substituerad - ergolin
FI56830B (fi) Foerfarande foer framstaellning av asparaginylgrupper innehaollande biologiskt aktiva polypeptider
SE415355B (sv) Forfarande for framstellning av fosfonotioureider
SE393808B (sv) Forfarande for framstellning av isomaltit
SE391717B (sv) Forfarande for framstellning av 4-aryl-5-aminoalkyl-4-oxazolin-2-oner
NO136750C (no) Fremgangsm}te for fremstilling av indanderivater
SE400086B (sv) Forfarande for framstellning av acylerade n(6)- aralkyl-adenosin-derivat
SE384027B (sv) Forfarande for framstellning av nya alfa-alkylsulfobensylpenicilliner
SE389862B (sv) Forfarande for framstellning av alfa-6-deoxitetracykliner
SE384210B (sv) Forfarande for framstellning av nya nitrosokarbamidderivat

Legal Events

Date Code Title Description
SPCF Application for supplementary protection certificate filed

Free format text: 7316562

SPCG Supplementary protection certificate granted

Free format text: 7316562, EXPIRES: 19990529