SE402764B - Forfarande for framstellning av nya hjertaktiva foreningar - Google Patents

Forfarande for framstellning av nya hjertaktiva foreningar

Info

Publication number
SE402764B
SE402764B SE7506348A SE7506348A SE402764B SE 402764 B SE402764 B SE 402764B SE 7506348 A SE7506348 A SE 7506348A SE 7506348 A SE7506348 A SE 7506348A SE 402764 B SE402764 B SE 402764B
Authority
SE
Sweden
Prior art keywords
procedure
producing new
new heart
active associations
heart active
Prior art date
Application number
SE7506348A
Other languages
English (en)
Other versions
SE7506348L (sv
Inventor
E I Carlsson
B T Lundgren
G B R Samuelsson
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Priority to SE7506348A priority Critical patent/SE402764B/sv
Priority to DE19752530613 priority patent/DE2530613A1/de
Priority to AT593075A priority patent/AT340898B/de
Priority to AU83638/75A priority patent/AU496294B2/en
Priority to NO752766A priority patent/NO141753C/no
Priority to SU752163124A priority patent/SU591137A3/ru
Priority to DD187767A priority patent/DD122073A5/xx
Priority to NL7509549A priority patent/NL7509549A/xx
Priority to FI752312A priority patent/FI752312A/fi
Priority to GB37072/75A priority patent/GB1518689A/en
Priority to CH1196675A priority patent/CH618416A5/de
Priority to IE2155/75A priority patent/IE42131B1/en
Priority to DK444375A priority patent/DK444375A/da
Priority to FR7532205A priority patent/FR2289173A1/fr
Priority to CS757327A priority patent/CS189725B2/cs
Priority to HU75HE00000693A priority patent/HU172651B/hu
Priority to LU73704A priority patent/LU73704A1/xx
Priority to CA238,765A priority patent/CA1065894A/en
Priority to JP50131346A priority patent/JPS51131841A/ja
Priority to SU762415408A priority patent/SU617007A3/ru
Priority to SU762415407A priority patent/SU624570A3/ru
Priority to AT821676A priority patent/AT341499B/de
Publication of SE7506348L publication Critical patent/SE7506348L/sv
Priority to CS771857A priority patent/CS189741B2/cs
Priority to CS771858A priority patent/CS189742B2/cs
Priority to US05/864,514 priority patent/US4161542A/en
Publication of SE402764B publication Critical patent/SE402764B/sv
Priority to CH822779A priority patent/CH618418A5/de
Priority to CH822879A priority patent/CH618419A5/de
Priority to IT7950876A priority patent/IT7950876A0/it
Priority to HK359/81A priority patent/HK35981A/xx
Priority to MY84/82A priority patent/MY8200084A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE7506348A 1974-11-01 1975-06-04 Forfarande for framstellning av nya hjertaktiva foreningar SE402764B (sv)

Priority Applications (30)

Application Number Priority Date Filing Date Title
SE7506348A SE402764B (sv) 1975-06-04 1975-06-04 Forfarande for framstellning av nya hjertaktiva foreningar
DE19752530613 DE2530613A1 (de) 1974-11-01 1975-07-09 Aminderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel
AT593075A AT340898B (de) 1974-11-01 1975-07-31 Verfahren zur herstellung neuer substituierter 1-phenoxy-2-hydroxy-3- (p-hydroxyphenylalkylamino)-alkane und deren saureadditionssalze
AU83638/75A AU496294B2 (en) 1974-11-01 1975-08-04 Phenoxyhydroxypropylamine derivatives
NO752766A NO141753C (no) 1974-11-01 1975-08-06 Analogifremgangsmaate for fremstilling av nye propanolaminer med beta-reseptor blokkerende og alfa-reseptor blokkerende effekt
SU752163124A SU591137A3 (ru) 1974-11-01 1975-08-08 Способ получени аминов или их солей
DD187767A DD122073A5 (sv) 1974-11-01 1975-08-08
NL7509549A NL7509549A (nl) 1974-11-01 1975-08-11 Amineverbindingen en farmaceutisch preparaat alsmede werkwijze voor het bereiden daarvan.
FI752312A FI752312A (sv) 1974-11-01 1975-08-14
GB37072/75A GB1518689A (en) 1974-11-01 1975-09-09 Aryloxy n-aralkyl propanolamines their preparation and pharmaceutical compositions containing them
CH1196675A CH618416A5 (en) 1974-11-01 1975-09-16 Process for the preparation of novel hydroxyamines
IE2155/75A IE42131B1 (en) 1974-11-01 1975-10-02 New aryloxy n-aralkyl propanolamines,their preparation andpharmaceutical compositions containing them
DK444375A DK444375A (da) 1974-11-01 1975-10-02 Fremgangsmade til fremstilling af hjerteaktive forbindelser
FR7532205A FR2289173A1 (fr) 1974-11-01 1975-10-21 Composes a base de phenoxy-hydroxypropylamine actifs contre les maladies cardiaques
HU75HE00000693A HU172651B (hu) 1974-11-01 1975-10-30 Sposob poluchenija zamehhennykh 3-skobka-2-skobka zakryta-4-gidroksi-fenil-skobka-etilamino-skobka zakryta-fenoksi-alkan-2-olov
CS757327A CS189725B2 (en) 1974-11-01 1975-10-30 Process for preparing substituted 1-phenoxy-3-p-hydroxyphenetylamino-2-hydroxyalkanoles
LU73704A LU73704A1 (sv) 1974-11-01 1975-10-31
CA238,765A CA1065894A (en) 1974-11-01 1975-10-31 Phenoxypropanolamines
JP50131346A JPS51131841A (en) 1974-11-01 1975-10-31 Process for preparing novel amine compound
SU762415408A SU617007A3 (ru) 1974-11-01 1976-11-01 Способ получени аминов или их солей
SU762415407A SU624570A3 (ru) 1974-11-01 1976-11-01 Способ получени аминов или их солей
AT821676A AT341499B (de) 1974-11-01 1976-11-05 Verfahren zur herstellung neuer substituierter 1-phenoxy-2-hydroxy-3- (p-hydroxyphenyl-alkylamino)-alkane und deren saureadditionssalze
CS771857A CS189741B2 (en) 1974-11-01 1977-03-01 Method of producing substituted 1-phenoxy-3-p-hydroxy-phenetylamino-2-hydroxyalkanols
CS771858A CS189742B2 (en) 1974-11-01 1977-03-21 Method of producing substituted 1-phenoxyl-1-p-hydroxy-phenetylamino-2-hydroxyalkanols
US05/864,514 US4161542A (en) 1975-06-04 1977-12-27 Heart active compounds
CH822779A CH618418A5 (en) 1974-11-01 1979-09-11 Process for the preparation of novel hydroxyamines
CH822879A CH618419A5 (en) 1974-11-01 1979-09-11 Process for the preparation of novel hydroxyamines
IT7950876A IT7950876A0 (it) 1974-11-01 1979-11-21 Procedimento per la preparazione dicomposti aventi attivita' di bloccaggio dei beta-recettori del cuore e prodotto ottenuto
HK359/81A HK35981A (en) 1974-11-01 1981-07-23 New aryloxy n-aralkyl propanolamines their preparation and pharmaceutical compositions containing them
MY84/82A MY8200084A (en) 1974-11-01 1982-12-30 New arylocy n-aralkyl propanolamines their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7506348A SE402764B (sv) 1975-06-04 1975-06-04 Forfarande for framstellning av nya hjertaktiva foreningar

Publications (2)

Publication Number Publication Date
SE7506348L SE7506348L (sv) 1976-12-05
SE402764B true SE402764B (sv) 1978-07-17

Family

ID=20324739

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7506348A SE402764B (sv) 1974-11-01 1975-06-04 Forfarande for framstellning av nya hjertaktiva foreningar

Country Status (2)

Country Link
US (1) US4161542A (sv)
SE (1) SE402764B (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376125A (en) * 1980-11-05 1983-03-08 University Of Virginia Alumni Patents Foundation Aminobenzlpropranolol and pharmaceutical preparation thereof
US5166218A (en) * 1983-10-19 1992-11-24 Hoffmann-La Roche Inc. Phenoxypropanolamines and pharmaceutical compositions thereof
CA1262729A (en) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
EP0300290B1 (de) * 1987-07-21 1991-12-18 F. Hoffmann-La Roche Ag Phenoxypropanolamine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459782A (en) * 1963-08-26 1969-08-05 Boehringer Sohn Ingelheim 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes
US3852468A (en) * 1967-02-27 1974-12-03 Ici Ltd Alkanolamine derivatives as {62 -adrenergic blocking agents
CA954861A (en) 1969-04-18 1974-09-17 Frosst (Charles E.) And Co. 1-(morpholino-phenoxy)-3-(substituted amino) propan-2-01s
FR2119845B1 (sv) * 1970-12-28 1974-03-22 Laroche Navarro Labo
FR2119844B1 (sv) * 1970-12-28 1974-03-22 Laroche Navarro Labo
FR2119843B1 (sv) * 1970-12-28 1974-03-22 Laroche Navarro Labo
US3929856A (en) * 1971-12-14 1975-12-30 Parke Davis & Co 1-(3,4-Dimethoxyphenethylamino)-3-(phenoxy)-2-propanols
US4067904A (en) * 1975-12-19 1978-01-10 Mead Johnson & Company Alkylsulfonylphenoxypropanolamine derivatives

Also Published As

Publication number Publication date
SE7506348L (sv) 1976-12-05
US4161542A (en) 1979-07-17

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