GB1518689A - Aryloxy n-aralkyl propanolamines their preparation and pharmaceutical compositions containing them - Google Patents
Aryloxy n-aralkyl propanolamines their preparation and pharmaceutical compositions containing themInfo
- Publication number
- GB1518689A GB1518689A GB37072/75A GB3707275A GB1518689A GB 1518689 A GB1518689 A GB 1518689A GB 37072/75 A GB37072/75 A GB 37072/75A GB 3707275 A GB3707275 A GB 3707275A GB 1518689 A GB1518689 A GB 1518689A
- Authority
- GB
- United Kingdom
- Prior art keywords
- resulting
- preparation
- formula
- image
- propanolamines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Treating Waste Gases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
For the preparation of novel hydroxyamines of the formula (I) <IMAGE> in which R<1>, R<2>, R<3> and R<4> have the meanings given in the Patent Claim, and the acid addition salts of these compounds, a starting compound of the formula (II) <IMAGE> is used. This compound is reacted with an amine of the formula <IMAGE> The resulting isomeric mixtures can be separated into the pure isomers and the resulting racemates into the optical antipodes. The resulting free bases can be converted into a therapeutically acceptable salt thereof or the resulting salts converted into the corresponding free bases. The novel hydroxyamines block cardiac beta -receptors. They are used for the treatment of arrhythmias, of angina pectoris and of hypertension.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7413789A SE422052B (en) | 1974-11-01 | 1974-11-01 | PROCEDURE FOR PREPARING CERTAIN STATED 1-PHENOXY-2-HYDROXY-3-AMINOPHENYL PROPYL DERIVATIVES |
| SE7506348A SE402764B (en) | 1975-06-04 | 1975-06-04 | PROCEDURE FOR PRODUCING NEW HEART ACTIVE ASSOCIATIONS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1518689A true GB1518689A (en) | 1978-07-19 |
Family
ID=26656538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37072/75A Expired GB1518689A (en) | 1974-11-01 | 1975-09-09 | Aryloxy n-aralkyl propanolamines their preparation and pharmaceutical compositions containing them |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS51131841A (en) |
| AT (1) | AT340898B (en) |
| CA (1) | CA1065894A (en) |
| CH (1) | CH618416A5 (en) |
| CS (1) | CS189725B2 (en) |
| DD (1) | DD122073A5 (en) |
| DE (1) | DE2530613A1 (en) |
| DK (1) | DK444375A (en) |
| FI (1) | FI752312A (en) |
| FR (1) | FR2289173A1 (en) |
| GB (1) | GB1518689A (en) |
| HK (1) | HK35981A (en) |
| HU (1) | HU172651B (en) |
| IE (1) | IE42131B1 (en) |
| IT (1) | IT7950876A0 (en) |
| LU (1) | LU73704A1 (en) |
| MY (1) | MY8200084A (en) |
| NL (1) | NL7509549A (en) |
| NO (1) | NO141753C (en) |
| SU (3) | SU591137A3 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432656B1 (en) | 1996-12-03 | 2002-08-13 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| US7202261B2 (en) | 1996-12-03 | 2007-04-10 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| EP2141146A1 (en) * | 2000-01-24 | 2010-01-06 | SmithKline Beecham Corporation | Calcilytic compounds |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818660B2 (en) | 1996-04-09 | 2004-11-16 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| IL126458A (en) | 1996-04-09 | 2004-06-20 | Nps Pharma Inc | Calcium receptor inhibiting calcilytic compounds |
-
1975
- 1975-07-09 DE DE19752530613 patent/DE2530613A1/en not_active Ceased
- 1975-07-31 AT AT593075A patent/AT340898B/en not_active IP Right Cessation
- 1975-08-06 NO NO752766A patent/NO141753C/en unknown
- 1975-08-08 SU SU752163124A patent/SU591137A3/en active
- 1975-08-08 DD DD187767A patent/DD122073A5/xx unknown
- 1975-08-11 NL NL7509549A patent/NL7509549A/en not_active Application Discontinuation
- 1975-08-14 FI FI752312A patent/FI752312A/fi not_active Application Discontinuation
- 1975-09-09 GB GB37072/75A patent/GB1518689A/en not_active Expired
- 1975-09-16 CH CH1196675A patent/CH618416A5/en not_active IP Right Cessation
- 1975-10-02 DK DK444375A patent/DK444375A/en not_active Application Discontinuation
- 1975-10-02 IE IE2155/75A patent/IE42131B1/en unknown
- 1975-10-21 FR FR7532205A patent/FR2289173A1/en active Granted
- 1975-10-30 CS CS757327A patent/CS189725B2/en unknown
- 1975-10-30 HU HU75HE00000693A patent/HU172651B/en unknown
- 1975-10-31 LU LU73704A patent/LU73704A1/xx unknown
- 1975-10-31 CA CA238,765A patent/CA1065894A/en not_active Expired
- 1975-10-31 JP JP50131346A patent/JPS51131841A/en active Pending
-
1976
- 1976-11-01 SU SU762415408A patent/SU617007A3/en active
- 1976-11-01 SU SU762415407A patent/SU624570A3/en active
-
1979
- 1979-11-21 IT IT7950876A patent/IT7950876A0/en unknown
-
1981
- 1981-07-23 HK HK359/81A patent/HK35981A/en unknown
-
1982
- 1982-12-30 MY MY84/82A patent/MY8200084A/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432656B1 (en) | 1996-12-03 | 2002-08-13 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| US7202261B2 (en) | 1996-12-03 | 2007-04-10 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| EP2141146A1 (en) * | 2000-01-24 | 2010-01-06 | SmithKline Beecham Corporation | Calcilytic compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| IE42131L (en) | 1976-05-01 |
| LU73704A1 (en) | 1976-08-13 |
| HU172651B (en) | 1978-11-28 |
| AU8363875A (en) | 1977-02-10 |
| NO141753B (en) | 1980-01-28 |
| FR2289173B1 (en) | 1980-11-21 |
| CS189725B2 (en) | 1979-04-30 |
| NO752766L (en) | 1976-05-04 |
| ATA593075A (en) | 1977-05-15 |
| MY8200084A (en) | 1982-12-31 |
| FI752312A (en) | 1976-05-02 |
| IT7950876A0 (en) | 1979-11-21 |
| JPS51131841A (en) | 1976-11-16 |
| DE2530613A1 (en) | 1976-05-06 |
| NO141753C (en) | 1980-05-07 |
| CH618416A5 (en) | 1980-07-31 |
| DK444375A (en) | 1976-05-02 |
| HK35981A (en) | 1981-07-31 |
| NL7509549A (en) | 1976-05-04 |
| SU624570A3 (en) | 1978-09-15 |
| DD122073A5 (en) | 1976-09-12 |
| IE42131B1 (en) | 1980-06-04 |
| FR2289173A1 (en) | 1976-05-28 |
| SU617007A3 (en) | 1978-07-25 |
| AT340898B (en) | 1978-01-10 |
| CA1065894A (en) | 1979-11-06 |
| SU591137A3 (en) | 1978-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |