GB1464209A - Preparation of cardio-active amines material - Google Patents

Preparation of cardio-active amines material

Info

Publication number
GB1464209A
GB1464209A GB3915075A GB3915075A GB1464209A GB 1464209 A GB1464209 A GB 1464209A GB 3915075 A GB3915075 A GB 3915075A GB 3915075 A GB3915075 A GB 3915075A GB 1464209 A GB1464209 A GB 1464209A
Authority
GB
United Kingdom
Prior art keywords
preparation
formula
cardio
active amines
reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3915075A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB1464209A publication Critical patent/GB1464209A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A process for the preparation of the compound of the formula I and its salts is described. It is based on the reduction of the acid amide of the formula II. The reduction is advantageously carried out using a complex metal hydride. The compound of the formula I forms racemates, the synthesis claimed leading to the optically active components. Under the name phendilin, the final substance is used pharmaceutically against angina pectoris. <IMAGE>
GB3915075A 1974-09-25 1975-09-24 Preparation of cardio-active amines material Expired GB1464209A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI1510A HU169507B (en) 1974-09-25 1974-09-25

Publications (1)

Publication Number Publication Date
GB1464209A true GB1464209A (en) 1977-02-09

Family

ID=10994536

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3915075A Expired GB1464209A (en) 1974-09-25 1975-09-24 Preparation of cardio-active amines material

Country Status (22)

Country Link
JP (1) JPS5159843A (en)
AR (2) AR210586A1 (en)
AT (1) AT337675B (en)
AU (1) AU497358B2 (en)
BE (1) BE833824A (en)
CH (2) CH609323A5 (en)
CS (2) CS186749B2 (en)
DD (1) DD124874A5 (en)
DE (1) DE2541184C2 (en)
DK (1) DK429075A (en)
FI (1) FI752595A (en)
FR (1) FR2285865A1 (en)
GB (1) GB1464209A (en)
HU (1) HU169507B (en)
IL (1) IL48120A (en)
IN (1) IN141186B (en)
NL (1) NL7511183A (en)
NO (1) NO753246L (en)
PL (2) PL107557B1 (en)
SE (1) SE7510611L (en)
SU (2) SU603331A3 (en)
YU (2) YU37112B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU709303B2 (en) * 1994-10-21 1999-08-26 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
US5981599A (en) * 1996-05-01 1999-11-09 Nps Pharmaceuticals, Inc. Inorganic ion receptor active compounds
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2862103D1 (en) * 1977-08-19 1982-11-18 Sandoz Ag Propenyl amines, processes for their production and pharmaceutical compositions containing them
FR2504524A1 (en) * 1981-04-22 1982-10-29 Spofa Vereinigte Pharma Werke N- (1-PHENYLTHYL) -N- (3,3-DIPHENYLPROPYL) -HYDROXYLAMINE AND PROCESS FOR THEIR PREPARATION
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6057346A (en) * 1994-12-12 2000-05-02 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of retroviral LTR promoters by calcium response modifiers
WO2014031755A1 (en) * 2012-08-21 2014-02-27 The Board Of Regents Of The University Of Texas System Fendiline derivatives and methods of use thereof
RU2739376C1 (en) * 2020-07-24 2020-12-23 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) Method of producing fendiline

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
AU709303B2 (en) * 1994-10-21 1999-08-26 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
US6211244B1 (en) 1994-10-21 2001-04-03 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
US5981599A (en) * 1996-05-01 1999-11-09 Nps Pharmaceuticals, Inc. Inorganic ion receptor active compounds
US6342532B1 (en) 1996-05-01 2002-01-29 Nps Pharmaceuticals, Inc. Inorganic ion receptor active compounds
US6710088B2 (en) 1996-05-01 2004-03-23 Nps Pharmaceuticals, Inc. Inorganic ion receptor-active compounds

Also Published As

Publication number Publication date
NL7511183A (en) 1976-03-29
IL48120A0 (en) 1975-11-25
ATA711175A (en) 1976-11-15
FR2285865B1 (en) 1980-05-30
AT337675B (en) 1977-07-11
BE833824A (en) 1976-01-16
PL107557B1 (en) 1980-02-29
CS186749B2 (en) 1978-12-29
FI752595A (en) 1976-03-26
PL108111B1 (en) 1980-03-31
AU8495675A (en) 1977-03-24
YU239475A (en) 1983-04-27
SU837319A3 (en) 1981-06-07
CH596139A5 (en) 1978-02-28
AR211558A1 (en) 1978-01-30
IL48120A (en) 1979-05-31
AU497358B2 (en) 1978-12-07
CH609323A5 (en) 1979-02-28
DK429075A (en) 1976-03-26
YU261181A (en) 1983-04-27
CS186718B2 (en) 1978-12-29
JPS5159843A (en) 1976-05-25
HU169507B (en) 1976-12-28
YU37112B (en) 1984-08-31
NO753246L (en) 1976-03-26
DE2541184A1 (en) 1976-04-15
DE2541184C2 (en) 1984-05-10
AR210586A1 (en) 1977-08-31
FR2285865A1 (en) 1976-04-23
IN141186B (en) 1977-01-29
DD124874A5 (en) 1977-03-16
SU603331A3 (en) 1978-04-15
YU37115B (en) 1984-08-31
SE7510611L (en) 1976-03-26

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
746 Register noted 'licences of right' (sect. 46/1977)
PCNP Patent ceased through non-payment of renewal fee