SE323170B - - Google Patents
Info
- Publication number
- SE323170B SE323170B SE13893/62A SE1389362A SE323170B SE 323170 B SE323170 B SE 323170B SE 13893/62 A SE13893/62 A SE 13893/62A SE 1389362 A SE1389362 A SE 1389362A SE 323170 B SE323170 B SE 323170B
- Authority
- SE
- Sweden
- Prior art keywords
- callikrein
- inactivator
- precipitating
- acetone
- extracted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
The callikrein inactivator is isolated from the waste fractions obtained during the production of insulin from the pancreas of animals, e.g. cattle and pigs, by known methods for the isolation of callikrein inactivator from extracts of animal organs containing the callikrein inactivator. These waste fractions are (a) the precipitate formed by neutralization of the acidic alcoholic pancreas extract, e.g. with ammonia to pH 7 to 8 and (b) the mother liquor remaining after the separation of crude insulin from the aqueous solution with 20 to 25% of sodium chloride. The precipitate of (a) may be extracted with aqueous methanol containing calcium chloride or manganous chloride, separating the extract and precipitating the callikrein inactivator by acetone in the presence of kieselguhr. After washing with acetone, the callikrein inactivator is extracted with water and may be further purified by precipitating waste proteins by sulphosulphosalicylic acid, followed by removal of excess precipitating agent by ion exchanger. Specifications 783,316, 886,989 and 916,932 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF35630A DE1161658B (en) | 1961-12-22 | 1961-12-22 | Obtaining the kallikrein inactivator from insulin waste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE323170B true SE323170B (en) | 1970-04-27 |
Family
ID=7096079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE13893/62A SE323170B (en) | 1961-12-22 | 1962-12-21 |
Country Status (7)
| Country | Link |
|---|---|
| CH (1) | CH449850A (en) |
| DE (1) | DE1161658B (en) |
| DK (1) | DK103411C (en) |
| FR (1) | FR1345316A (en) |
| GB (1) | GB965352A (en) |
| NL (1) | NL287049A (en) |
| SE (1) | SE323170B (en) |
-
0
- NL NL287049D patent/NL287049A/xx unknown
-
1961
- 1961-12-22 DE DEF35630A patent/DE1161658B/en active Pending
-
1962
- 1962-11-20 CH CH1357162A patent/CH449850A/en unknown
- 1962-12-06 GB GB4609862A patent/GB965352A/en not_active Expired
- 1962-12-20 DK DK556762A patent/DK103411C/en active
- 1962-12-21 SE SE13893/62A patent/SE323170B/xx unknown
- 1962-12-21 FR FR919513A patent/FR1345316A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL287049A (en) | |
| FR1345316A (en) | 1963-12-06 |
| GB965352A (en) | 1964-07-29 |
| CH449850A (en) | 1968-01-15 |
| DE1161658B (en) | 1964-01-23 |
| DK103411C (en) | 1965-12-27 |
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