SE309776B - - Google Patents
Info
- Publication number
- SE309776B SE309776B SE1310665A SE1310665A SE309776B SE 309776 B SE309776 B SE 309776B SE 1310665 A SE1310665 A SE 1310665A SE 1310665 A SE1310665 A SE 1310665A SE 309776 B SE309776 B SE 309776B
- Authority
- SE
- Sweden
- Prior art keywords
- ethoxy
- oxo
- pregnane
- acetoxy
- reaction
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Abstract
The invention comprises a 21-[(b -ethoxy)n-ethoxy] - acetoxy - 20 - oxo - pregnane wherein n is either 1 or 2 and a process for the preparation thereof in which a 21-hydroxy-20-oxo-steroid of the general formula St-CO-CH2OH (where St represents a steroid nucleus of the pregnane series) is esterified by reaction with an organic acid of the formula CH3-CH2-O-(CH2-CH2-O)n-CH2COOH (wherein n is either 1 or 2) or a functional derivative thereof, to form the corresponding 21-[(b - ethoxy)n - ethoxy] - acetoxy - 20 - oxo-pregnane. The ethoxy acetic acid, or derivative thereof, may be prepared by reaction of the corresponding alkali-metal alcoholate with a mono-halogeno-acetic acid or a salt thereof. Pharmaceutical compositions having anti-inflammatory and/or anti-pruriginous activity and containing the above compounds are applied topically to the skin or mucosa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR993810A FR1514082A (en) | 1964-11-04 | 1964-11-04 | New steroid esters at position 21 and method of preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
SE309776B true SE309776B (en) | 1969-04-08 |
Family
ID=8841771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE1310665A SE309776B (en) | 1964-11-04 | 1965-10-08 |
Country Status (12)
Country | Link |
---|---|
AT (1) | AT257853B (en) |
BE (1) | BE671392A (en) |
BR (1) | BR6574584D0 (en) |
CH (1) | CH445484A (en) |
DE (1) | DE1468945A1 (en) |
DK (1) | DK113920B (en) |
ES (1) | ES319114A1 (en) |
FR (1) | FR1514082A (en) |
GB (1) | GB1087730A (en) |
IL (1) | IL24502A (en) |
NL (2) | NL6514035A (en) |
SE (1) | SE309776B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2183555B1 (en) * | 1972-05-10 | 1975-06-20 | Roussel Uclaf | |
US4472392A (en) * | 1983-01-21 | 1984-09-18 | The Upjohn Company | Sulfonate containing ester prodrugs of corticosteroids |
-
0
- NL NL124139D patent/NL124139C/xx active
-
1964
- 1964-11-04 FR FR993810A patent/FR1514082A/en not_active Expired
-
1965
- 1965-10-08 SE SE1310665A patent/SE309776B/xx unknown
- 1965-10-18 DK DK531765A patent/DK113920B/en unknown
- 1965-10-21 IL IL2450265A patent/IL24502A/en unknown
- 1965-10-21 CH CH1455565A patent/CH445484A/en unknown
- 1965-10-25 BE BE671392D patent/BE671392A/xx unknown
- 1965-10-29 NL NL6514035A patent/NL6514035A/xx unknown
- 1965-10-30 ES ES0319114A patent/ES319114A1/en not_active Expired
- 1965-11-03 GB GB4651965A patent/GB1087730A/en not_active Expired
- 1965-11-04 AT AT999265A patent/AT257853B/en active
- 1965-11-04 BR BR17458465A patent/BR6574584D0/en unknown
- 1965-11-04 DE DE19651468945 patent/DE1468945A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
IL24502A (en) | 1969-12-31 |
ES319114A1 (en) | 1965-12-16 |
DE1468945A1 (en) | 1969-02-06 |
GB1087730A (en) | 1967-10-18 |
FR1514082A (en) | 1968-02-23 |
CH445484A (en) | 1967-10-31 |
AT257853B (en) | 1967-10-25 |
NL124139C (en) | |
BE671392A (en) | 1966-04-25 |
NL6514035A (en) | 1966-05-05 |
DK113920B (en) | 1969-05-12 |
BR6574584D0 (en) | 1973-09-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES438946A2 (en) | Vincaminic acid esters | |
GB1048231A (en) | New steroid compounds, compositions incorporating them and processes for their preparation | |
SE309776B (en) | ||
GB951107A (en) | Improvements relating to a-nor-steroid compounds | |
GB1031905A (en) | Novel steroid compounds, their preparation and pharmaceutical compositions containing them | |
GB901293A (en) | Improvements in or relating to steroids | |
GB1472922A (en) | Pregnanoic acid derivatives | |
GB1060791A (en) | Improvements in or relating to steroids and the manufacture thereof | |
ES421713A1 (en) | Pregnane acid derivatives | |
GB1087729A (en) | Novel pharmacologically active steroid compounds of the pregnane series, processes for their preparation, and pharmaceutical compositions containing them | |
DE2109305C3 (en) | 20-Hydroxylated 17 a - methyl-19-nor-pregna-4,9-dienes, process for their preparation and intermediates | |
GB1077393A (en) | New steroids | |
GB974719A (en) | Improvements in or relating to steroid compounds and therapeutic compositions containing steroid compounds | |
GB935610A (en) | 3ªá-amino-pregnane compounds | |
GB1094806A (en) | Unsaturated steroid compounds and processes for their preparation | |
GB961343A (en) | Tetrahydrofurfuryl 3-pyridylacetate | |
US3452060A (en) | 17-hydroxy-17-(3-oxo-1-propynyl or-propenyl) steroids | |
GB1018780A (en) | Steroid (2,3í¬c) furazan compounds and the process for the production thereof | |
GB1043156A (en) | 10-hydroxy-19-norandrostanes | |
GB946575A (en) | Improvements in or relating to steroids | |
GB795102A (en) | Improvements in or relating to steroid compounds and the preparation thereof | |
GB959793A (en) | Improvements in or relating to steroids | |
GB839376A (en) | Steroid compounds and their preparation | |
GB1016375A (en) | Steroid esters | |
GB884177A (en) | Improvements in or relating to pregnene derivatives |