SE0400199D0 - HCV Protease inhbitors - Google Patents
HCV Protease inhbitorsInfo
- Publication number
- SE0400199D0 SE0400199D0 SE0400199A SE0400199A SE0400199D0 SE 0400199 D0 SE0400199 D0 SE 0400199D0 SE 0400199 A SE0400199 A SE 0400199A SE 0400199 A SE0400199 A SE 0400199A SE 0400199 D0 SE0400199 D0 SE 0400199D0
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- protease inhibitors
- hcv protease
- cleavage site
- linkage
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Priority Applications (68)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0400199A SE0400199D0 (sv) | 2004-01-30 | 2004-01-30 | HCV Protease inhbitors |
TW094102721A TWI367211B (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
CN200580003410.0A CN1914224B (zh) | 2004-01-30 | 2005-01-28 | Hcv ns-3丝氨酸蛋白酶抑制剂 |
CA2552317A CA2552317C (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
PL05704764T PL1713822T3 (pl) | 2004-01-30 | 2005-01-28 | Inhibitory proteazy serynowej HCV NS-3 |
ES05704764T ES2342944T3 (es) | 2004-01-30 | 2005-01-28 | Inhibidores de ns-3 serina proteasa de vhc. |
BRPI0506945-9A BRPI0506945A (pt) | 2004-01-30 | 2005-01-28 | inibidores de serina protease ns-3 de hcv |
PCT/SE2005/000096 WO2005073216A2 (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
UAA200608624A UA84050C2 (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3-serine protease inhibitors |
TW094102697A TWI361195B (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
NZ548739A NZ548739A (en) | 2004-01-30 | 2005-01-28 | HCV NS-3 Serine protease inhibitors |
KR1020127011467A KR20120090077A (ko) | 2004-01-30 | 2005-01-28 | Hcv ns?3 세린 프로테아제 저해제 |
ARP050100340A AR048401A1 (es) | 2004-01-30 | 2005-01-28 | Inhibidores de la serina-proteasa ns3 del vhc |
BRPI0506948A BRPI0506948B1 (pt) | 2004-01-30 | 2005-01-28 | inibidores de serina protease ns-3 de hcv |
JP2006551001A JP4902361B2 (ja) | 2004-01-30 | 2005-01-28 | Hcvns−3セリンプロテアーゼインヒビター |
EA200601399A EA012410B1 (ru) | 2004-01-30 | 2005-01-28 | Ингибиторы серин-протеазы ns-3 hcv |
JP2006551000A JP5248783B2 (ja) | 2004-01-30 | 2005-01-28 | Hcvns−3セリンプロテアーゼインヒビター |
SI200530899T SI1713823T1 (sl) | 2004-01-30 | 2005-01-28 | Inhibitorji HCV NS-3 serin proteaze |
CA2552319A CA2552319C (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
DK05704765.6T DK1713823T3 (da) | 2004-01-30 | 2005-01-28 | HCV NS-3 serinproteaseinhibitorer |
PL05704765T PL1713823T3 (pl) | 2004-01-30 | 2005-01-28 | Inhibitory proteazy serynowej NS-3 HCV |
EA200601400A EA014584B1 (ru) | 2004-01-30 | 2005-01-28 | Ингибиторы ns-3 сериновой протеазы hcv |
DE602005019979T DE602005019979D1 (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitoren |
PCT/SE2005/000097 WO2005073195A2 (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
EP05704764A EP1713822B1 (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
ES05704765T ES2336009T3 (es) | 2004-01-30 | 2005-01-28 | Inhibidores de la ns-3 serina proteasa del vhc. |
DK05704764.9T DK1713822T3 (da) | 2004-01-30 | 2005-01-28 | HCV NS-3 serine protease inhibitorer |
US10/572,418 US7608590B2 (en) | 2004-01-30 | 2005-01-28 | HCV NS-3 serine protease inhibitors |
AU2005207815A AU2005207815B2 (en) | 2004-01-30 | 2005-01-28 | HCV NS-3 serine protease inhibitors |
PT05704765T PT1713823E (pt) | 2004-01-30 | 2005-01-28 | Inibidores da protease ns-3 da serina do hcv |
AT05704764T ATE461209T1 (de) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitoren |
RSP-2010/0036A RS51243B (sr) | 2004-01-30 | 2005-01-28 | Inhibitori ns-3 serina hcv proteaze |
MYPI20050347A MY146349A (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
UAA200608686A UA84189C2 (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
CN2005800034238A CN1914225B (zh) | 2004-01-30 | 2005-01-28 | Hcv ns-3丝氨酸蛋白酶抑制剂 |
KR1020067017480A KR101159575B1 (ko) | 2004-01-30 | 2005-01-28 | Hcv ns―3 세린 프로테아제 저해제 |
ARP050100341A AR047793A1 (es) | 2004-01-30 | 2005-01-28 | Inhibidores de la serina proteasa ns-3 del vhc |
NZ548740A NZ548740A (en) | 2004-01-30 | 2005-01-28 | HCV NS-3 Serine protease inhibitors |
AT05704765T ATE448243T1 (de) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitoren |
US10/572,349 US7671032B2 (en) | 2004-01-30 | 2005-01-28 | HCV NS-3 serine protease inhibitors |
DE602005017582T DE602005017582D1 (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitoren |
EP05704765A EP1713823B1 (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
AU2005207816A AU2005207816C1 (en) | 2004-01-30 | 2005-01-28 | HCV NS-3 serine protease inhibitors |
MYPI20050349 MY153011A (en) | 2004-01-30 | 2005-01-28 | Hcv ns-3 serine protease inhibitors |
IL176848A IL176848A (en) | 2004-01-30 | 2006-07-13 | Compounds of 3– hcv ns Serine Protease, Pharmaceutical Preparations Containing and Using Them |
IL176921A IL176921A (en) | 2004-01-30 | 2006-07-18 | Hcv ns-3 serine protease inhibitors, pharmaceutical compositions comprising them and uses thereof in the manufacture of a medicament for the prophylaxis or treatment of flavivirus infections such as hcv |
EC2006006726A ECSP066726A (es) | 2004-01-30 | 2006-07-24 | Inhibidores de serina proteasa ns-3 del vhc |
EC2006006725A ECSP066725A (es) | 2004-01-30 | 2006-07-24 | Inhibidores de serina proteasa ns-3 del vhc |
CR8539A CR8539A (es) | 2004-01-30 | 2006-07-28 | Inhibidores de serina proteasa ns-3 del vhc |
NI200600168A NI200600168A (es) | 2004-01-30 | 2006-07-28 | Inhibidores de serina proteasa ns-3 del vhc |
CR8540A CR8540A (es) | 2004-01-30 | 2006-07-28 | Inhibidores de serina proteasa ns-3 del vhc |
KR1020067016960A KR101217036B1 (ko) | 2004-01-30 | 2006-08-23 | Hcv ns-3 세린 프로테아제 저해제 |
ZA2006/07214A ZA200607214B (en) | 2004-01-30 | 2006-08-29 | Hcv ns-3 serine protease inhibitors |
NO20063851A NO341392B1 (no) | 2004-01-30 | 2006-08-29 | HCV NS3-serinproteasehemmere |
NO20063850A NO340695B1 (no) | 2004-01-30 | 2006-08-29 | HCV NS-3 Serinproteasehemmere |
ZA200607215A ZA200607215B (en) | 2004-01-30 | 2006-08-29 | HCV NS-3 serine protease inhibitors |
HK07108629.5A HK1100881A1 (en) | 2004-01-30 | 2007-08-08 | Hcv ns-3 serine protease inhibitors hcv ns-3 |
HK07108691.8A HK1104044A1 (en) | 2004-01-30 | 2007-08-10 | Hcv ns-3 serine protease inhibitors hcv ns-3 |
US12/557,638 US20100003216A1 (en) | 2004-01-30 | 2009-09-11 | HCV NS-3 Serine Protease Inhibitors |
US12/642,984 US20100166706A1 (en) | 2004-01-30 | 2009-12-21 | Hcv ns-3 serine protease inhibitors |
HR20100048T HRP20100048T1 (hr) | 2004-01-30 | 2010-01-27 | Inhibitori hcv ns-3 serin proteaze |
CY20101100134T CY1109779T1 (el) | 2004-01-30 | 2010-02-10 | Αναστολεις της hcv ns-3 πρωτεασης σερινης |
JP2010279178A JP2011140488A (ja) | 2004-01-30 | 2010-12-15 | Hcvns−3セリンプロテアーゼインヒビター |
JP2013234011A JP5795619B2 (ja) | 2004-01-30 | 2013-11-12 | Hcvns−3セリンプロテアーゼインヒビター |
LU92595C LU92595I2 (fr) | 2004-01-30 | 2014-11-11 | Siméprévir, ou l'un de ses sels pharmaceutiquementacceptables, incluant siméprévir sodium |
NL300703C NL300703I2 (nl) | 2004-01-30 | 2014-11-12 | Simeprevir, of een farmaceutisch aanvaardbaar zout daarvan, waaronder simeprevirnatrium. |
ARP160101214A AR104445A2 (es) | 2004-01-30 | 2016-04-28 | Compuestos inhibidores de la serina proteasa ns3 del vhc y composición farmacéutica |
US15/470,599 US10172846B2 (en) | 2004-01-30 | 2017-03-27 | HCV NS-3 serine protease inhibitors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0400199A SE0400199D0 (sv) | 2004-01-30 | 2004-01-30 | HCV Protease inhbitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0400199D0 true SE0400199D0 (sv) | 2004-01-30 |
Family
ID=31713267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0400199A SE0400199D0 (sv) | 2004-01-30 | 2004-01-30 | HCV Protease inhbitors |
Country Status (5)
Country | Link |
---|---|
CN (2) | CN1914225B (no) |
AR (1) | AR104445A2 (no) |
NO (1) | NO340695B1 (no) |
SE (1) | SE0400199D0 (no) |
ZA (1) | ZA200607215B (no) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20070211A1 (es) * | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
CN108101811A (zh) * | 2016-11-25 | 2018-06-01 | 斯福瑞(南通)制药有限公司 | 生产n-叔丁氧羰基-2-氨基-3,3-二甲基丁酸的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
MY140680A (en) * | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
-
2004
- 2004-01-30 SE SE0400199A patent/SE0400199D0/xx unknown
-
2005
- 2005-01-28 CN CN2005800034238A patent/CN1914225B/zh not_active Expired - Fee Related
- 2005-01-28 CN CN200580003410.0A patent/CN1914224B/zh not_active Expired - Fee Related
-
2006
- 2006-08-29 NO NO20063850A patent/NO340695B1/no not_active IP Right Cessation
- 2006-08-29 ZA ZA200607215A patent/ZA200607215B/en unknown
-
2016
- 2016-04-28 AR ARP160101214A patent/AR104445A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
NO20063850L (no) | 2006-08-29 |
NO340695B1 (no) | 2017-06-06 |
CN1914224A (zh) | 2007-02-14 |
AR104445A2 (es) | 2017-07-19 |
CN1914225B (zh) | 2012-09-26 |
CN1914225A (zh) | 2007-02-14 |
CN1914224B (zh) | 2014-01-29 |
ZA200607215B (en) | 2008-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY153011A (en) | Hcv ns-3 serine protease inhibitors | |
ATE486889T1 (de) | Peptidanaloga mit inhibitorischer wirkung auf hepatitis c | |
ATE474827T1 (de) | Hcv-replikationshemmer | |
NO20075616L (no) | Tripeptider som hepatitt C virus inhibitorer | |
UY28525A1 (es) | Péptidos macrociclicos activos contra en virus de la hepatitis c | |
AR030591A1 (es) | Inhibidores de proteasa peptidomimetica | |
ATE492558T1 (de) | Makrocyclische peptide als hepatitis-c-virus- hemmer | |
NO20091846L (no) | Makrocykliske peptider som hepatitt C virus- inhibitorer | |
WO2009055335A3 (en) | Hcv protease inhibitors | |
WO2007089618A3 (en) | Hepatitis c serine protease inhibitors and uses therefor | |
TW200615275A (en) | Hepatitis C inhibitor dipeptide analogs | |
ECSP045191A (es) | "nuevos péptidos como inhibidores de la proteasa serina ns3 del virus de la hepatitis c" | |
ATE512971T1 (de) | Peptidanaloga als hepatitis c-hemmer | |
UA83046C2 (ru) | Соединения как ингибиторы вируса гепатита с, фармацевтическая композиция на их основе | |
ATE344056T1 (de) | Pharmazeutische zusammensetzungen für protease- hemmer für hepatitis-c-virus | |
UY28722A1 (es) | Peptidos macrociclicos activos contra el virus del a hepatitis c | |
MX2012006877A (es) | Inhibidores de virus de hepatitis c de arileno o heteroarileno 5, 5 - fusionado. | |
WO2007016476A3 (en) | Hepatitis c serine protease inhibitors and uses therefor | |
TW200728317A (en) | Macrocylic inhibitors of hepatitis C virus | |
GEP20094751B (en) | Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same | |
AR043929A1 (es) | Fases cristalinas de un inhibidor del hcv | |
WO2007092645A3 (en) | Novel hcv inhibitor combinations and methods | |
WO2010034105A8 (en) | Hepatitis c inhibitor compounds | |
WO2012019299A9 (en) | Hepatitis c inhibitor compounds | |
ATE383084T1 (de) | Sosse auf käsebasis |