RU99116252A - METHOD OF OBTAINING IMIDAZOL DERIVATIVES - Google Patents

Claims (6)

1. The method of obtaining the compounds of formula (III)

wherein R ¹ represents hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylthio, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted aralkyl, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted alkoxycarbonyl, -CH = NOH , -CH = NNH _2, or -A-X wherein A represents -CH ₂ OCH ₂ - or -CH ₂ O- and X is an optionally substituted aryl or COR ^5, where R ⁵ is optionally substituted ny alkyl, optionally substituted alkoxy, optionally substituted aryl or optionally substituted amino;
R ² represents an organic group; R ³ represents hydrogen or an organic group; and R ⁴ is an optionally substituted aryl, comprising reacting a compound of formula (I)

where R ¹ , R ² and R ³ have the above values, with the compound of the formula (II)
R ⁴ -S-Hal
where R ⁴ has the above values, and Hal represents a halogen, in the presence of a base. 2. The method according to claim 1, wherein the organic group is an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted aryl, an optionally substituted arylthio, an optionally substituted heteroaryl, an optionally substituted heteroarylalkyl, an optionally substituted aralkyl, an optionally substituted acyl, an optionally substituted carbamoyl, an optionally substituted alkoxycarbonyl, -CH = NOH, -CH = NNH ₂ or -A-X, where A is -CH ₂ OCH ₂ - or -CH ₂ O- and X is an optionally substituted aryl or -COR ⁵ , where R ⁵ is is an optionally substituted alkyl, an optionally substituted alkoxy, an optionally substituted aryl, or an optionally substituted amino. 3. The method according to claim 1 or 2, wherein R ¹ is hydrogen or an optionally substituted heteroarylalkyl; R ² is —A — X, where A is —CH ₂ OCH ₂ - or —CH ₂ O— and X is an optionally substituted aryl or —COR ⁵ , where R ⁵ is an optionally substituted alkyl, an optionally substituted alkoxy, an optionally substituted aryl, or optionally substituted amino, and R ³ is an optionally substituted alkyl. 4. The method according to any one of claims 1 to 3, where R ¹ is an optionally substituted pyridylmethyl.  5. The method according to any one of claims 1 to 4, where the compound of formula (II) is 3,5-dichlorobenzenesulfenyl chloride.  6. The method according to any one of claims 1 to 5, wherein said base is triethylamine or N-methylmorpholine.