RU92004429A - DERIVATIVES 2- (1-PIPERASINIL) -4-PHENYL-CYCLO-ALKANOPYRIDINE - Google Patents

DERIVATIVES 2- (1-PIPERASINIL) -4-PHENYL-CYCLO-ALKANOPYRIDINE

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Publication number
RU92004429A
RU92004429A RU92004429/04A RU92004429A RU92004429A RU 92004429 A RU92004429 A RU 92004429A RU 92004429/04 A RU92004429/04 A RU 92004429/04A RU 92004429 A RU92004429 A RU 92004429A RU 92004429 A RU92004429 A RU 92004429A
Authority
RU
Russia
Prior art keywords
alkyl
phenyl
hydrogen atom
piperasinil
alkanopyridine
Prior art date
Application number
RU92004429/04A
Other languages
Russian (ru)
Other versions
RU2075478C1 (en
Inventor
Хино Катсухико
Каи Наоки
Сакамото Масато
Кон Татсуя
Ока Макото
Фурукава Киеси
Оти Есиаки
Original Assignee
Дайниппон Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайниппон Фармасьютикал Ко., Лтд. filed Critical Дайниппон Фармасьютикал Ко., Лтд.
Publication of RU92004429A publication Critical patent/RU92004429A/en
Application granted granted Critical
Publication of RU2075478C1 publication Critical patent/RU2075478C1/en

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Claims (1)

Предложены соединения формулы (I) :
ЫЫЫ (I)
в которой n =3,4,5,6 или 7; R1 - атом водорода , С1 - С1 0 алкил, С2 - С6 алкенил, С2 - С6 алкинил, С3 - С8 циклоалкил, С3 - С6 циклоалкил - (С1 - С4) алкил, гидрокси - (С2 - С6) алкил, С1 - С3 алкокси - (С2 - С6) алкил, ацилокси - (С2 - С6) алкил, незамещенный или замещенный ароил - (С1 - С6) алкил, незамещенный или замещенный арил, гетероарил, или ацил; R2 и R3 одинаковые или различные, каждый представляет атом водорода, атом галогена, С1 - С6 алкил, С1 - С6 алкокси, трифторметил, или гидрокси; R4, R5 и R6 одинаковые или различные, каждый представляет атом водорода, С1 - С6 алкил, или фенил, или два из R4, R5 и R6 соединяются с образованием одинарной связи или C1 - C3 алкилена; R7 и R8 одинаковые или различные, каждый представляет атом водорода или С1 - С3 алкил; m =2 или 3, и их кислотно-аддитивные соли.The proposed compounds of formula (I):
YYY (I)
in which n = 3,4,5,6 or 7; R 1 is a hydrogen atom, C 1 - C 1 0 alkyl, C 2 - C 6 alkenyl, C 2 - C 6 alkynyl, C 3 - C 8 cycloalkyl, C 3 - C 6 cycloalkyl - (C 1 - C 4 ) alkyl , hydroxy - (C 2 - C 6 ) alkyl, C 1 - C 3 alkoxy - (C 2 - C 6 ) alkyl, acyloxy - (C 2 - C 6 ) alkyl, unsubstituted or substituted aroyl - (C 1 - C 6 a) alkyl, unsubstituted or substituted aryl, heteroaryl, or acyl; R 2 and R 3 are the same or different, each represents a hydrogen atom, a halogen atom, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, trifluoromethyl, or hydroxy; R 4 , R 5 and R 6 are the same or different, each represents a hydrogen atom, C 1 - C 6 alkyl, or phenyl, or two of R 4 , R 5 and R 6 combine to form a single bond or C 1 - C 3 alkylene ; R 7 and R 8 are the same or different, each represents a hydrogen atom or C 1 - C 3 alkyl; m = 2 or 3, and their acid addition salts.
RU92004429/04A 1989-03-03 1992-11-12 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hex- -ahydrocycloocta[b]pyridine or its acid-additive salt RU2075478C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5254489 1989-03-03
JP52544/1989 1989-03-03
JP52544/89 1989-03-03

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU4743292 Division

Publications (2)

Publication Number Publication Date
RU92004429A true RU92004429A (en) 1995-08-20
RU2075478C1 RU2075478C1 (en) 1997-03-20

Family

ID=12917732

Family Applications (1)

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RU92004429/04A RU2075478C1 (en) 1989-03-03 1992-11-12 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hex- -ahydrocycloocta[b]pyridine or its acid-additive salt

Country Status (15)

Country Link
US (1) US5021421A (en)
EP (1) EP0385237B1 (en)
KR (1) KR0149649B1 (en)
AT (1) ATE107922T1 (en)
AU (1) AU623981B2 (en)
CA (1) CA2011346C (en)
DD (1) DD292909A5 (en)
DE (1) DE69010232T2 (en)
DK (1) DK0385237T3 (en)
ES (1) ES2058630T3 (en)
FI (1) FI94413C (en)
HK (1) HK1005872A1 (en)
HU (1) HU204810B (en)
NO (1) NO177095C (en)
RU (1) RU2075478C1 (en)

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