RU99107824A - TABLET COMPOSITION AND METHOD FOR PREPARING TABLETS - Google Patents

TABLET COMPOSITION AND METHOD FOR PREPARING TABLETS

Info

Publication number
RU99107824A
RU99107824A RU99107824/14A RU99107824A RU99107824A RU 99107824 A RU99107824 A RU 99107824A RU 99107824/14 A RU99107824/14 A RU 99107824/14A RU 99107824 A RU99107824 A RU 99107824A RU 99107824 A RU99107824 A RU 99107824A
Authority
RU
Russia
Prior art keywords
polyvinylpyrrolidone
lignin
aqueous solution
mixed
subjected
Prior art date
Application number
RU99107824/14A
Other languages
Russian (ru)
Other versions
RU2166953C2 (en
Inventor
Александр Владимирович Диковский
Леонид Власович Неумывакин
Original Assignee
Закрытое акционерное общество "ЛЕКС"
Filing date
Publication date
Application filed by Закрытое акционерное общество "ЛЕКС" filed Critical Закрытое акционерное общество "ЛЕКС"
Priority to RU99107824/14A priority Critical patent/RU2166953C2/en
Priority claimed from RU99107824/14A external-priority patent/RU2166953C2/en
Publication of RU99107824A publication Critical patent/RU99107824A/en
Application granted granted Critical
Publication of RU2166953C2 publication Critical patent/RU2166953C2/en

Links

Claims (1)

1. Композиция для таблетирования, содержащая эктеросорбент и вспомогательные вещества, отличающаяся тем, что в качестве энтеросорбента она содержит гидролизный лигнин, а в качестве вспомогательных веществ - поливинилпирролидон и кальция стеарат при следующем соотношении компонентов, мас.%:
Гидролизный лигнин (в пересчете на сухое вещество) - 88,0 - 92,0
Поливинилпирролидон низкомолекулярный медицинский - 7,0 - 8,0
Кальция стеарат - Остальное
2. Способ приготовления таблеток, включающий смешивание активного и вспомогательных ингредиентов и таблетирование, отличающийся тем, что в качестве активного ингредиента используют энтеросорбент гидролизный лигнин, в качестве вспомогательных поливинилпирролидон и кальция стеарат, причем гидролизный лигнин смешивают с водным раствором поливинилпирролидона, полученную массу подвергают влажному гранулированию, полученный влажный гранулят сушат, высушенный гранулят подвергают сухому гранулированию, полученный гранулят опудривают кальция стеаратом и затем таблетируют.
1. Composition for tabletting, containing ekterosorbent and excipients, characterized in that it contains hydrolytic lignin as enterosorbent, and polyvinylpyrrolidone and calcium stearate as auxiliary substances in the following ratio of components, wt.%:
Hydrolysis lignin (in terms of dry substance) - 88.0 - 92.0
Low molecular weight medical polyvinylpyrrolidone - 7.0 - 8.0
Calcium Stearate - Else
2. The method of preparation of tablets, which includes mixing the active and auxiliary ingredients and tableting, characterized in that enterosorbent hydrolysis lignin is used as the active ingredient, polyvinylpyrrolidone and calcium stearate are used as auxiliary polyvinylpyrrolidone, the hydrolysis lignin is mixed with an aqueous solution of polyvinylpyrrolidone, the mass is subjected to a moist plastic lignin mixed with an aqueous solution of polyvinylpyrrolidone, the mass is subjected to a moist plastic lignin mixed with an aqueous solution of polyvinylpyrrolidone, subjected to a moist mass that is hydrolyzed lignin mixed with an aqueous solution of polyvinylpyrrolidone, exposed to a moist, lignin mixed with an aqueous solution of a polyvinylpyrrolidone, subjected to a moist, lignin mixed with an aqueous solution of polyvinylpyrrolidone , the obtained wet granulate is dried, the dried granulate is subjected to dry granulation, the resulting granulate is powdered as liqueur stearate and then tableted.
3. Способ по п. 2, отличающийся тем, что гидролизный лигнин о влажностью 55 - 75%, смешивают с 18 - 22%-ным водным раствором поливинилпирролидона, который в процессе перемешивания добавляют порциями в 2 - 4 приема, после чего перемешивание продолжают до полного и равномерного увлажнения массы, а полученный влажный гранулят сушат при темнературе 60 - 70oС до остаточной влажности 3 - 5%.3. The method according to p. 2, characterized in that the hydrolytic lignin is about 55 - 75% moisture, mixed with 18 - 22% aqueous solution of polyvinylpyrrolidone, which in the process of mixing is added in portions in 2 to 4 doses, after which the mixing is continued until full and uniform wetting of the mass, and the resulting wet granules are dried at temperature 60 - 70 o C to a residual moisture content of 3 - 5%.
RU99107824/14A 1999-04-12 1999-04-12 Composition for tabletting and method of tablet making RU2166953C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU99107824/14A RU2166953C2 (en) 1999-04-12 1999-04-12 Composition for tabletting and method of tablet making

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU99107824/14A RU2166953C2 (en) 1999-04-12 1999-04-12 Composition for tabletting and method of tablet making

Publications (2)

Publication Number Publication Date
RU99107824A true RU99107824A (en) 2001-02-20
RU2166953C2 RU2166953C2 (en) 2001-05-20

Family

ID=20218603

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99107824/14A RU2166953C2 (en) 1999-04-12 1999-04-12 Composition for tabletting and method of tablet making

Country Status (1)

Country Link
RU (1) RU2166953C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2674589C1 (en) * 2017-06-15 2018-12-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Уральский государственный экономический университет" (УрГЭУ) Specialized food product to maintain body metabolic processes in conditions of psycho-physiological stress and method for its preparation

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