RU96102017A - STABILIZED PHARMACEUTICAL PEPTIDE COMPOSITIONS - Google Patents
STABILIZED PHARMACEUTICAL PEPTIDE COMPOSITIONSInfo
- Publication number
- RU96102017A RU96102017A RU96102017/14A RU96102017A RU96102017A RU 96102017 A RU96102017 A RU 96102017A RU 96102017/14 A RU96102017/14 A RU 96102017/14A RU 96102017 A RU96102017 A RU 96102017A RU 96102017 A RU96102017 A RU 96102017A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- composition according
- specified
- citrate
- phosphate
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 28
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-K 2qpq Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 7
- 239000010452 phosphate Substances 0.000 claims 7
- 230000003204 osmotic Effects 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 229960000686 Benzalkonium Chloride Drugs 0.000 claims 3
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 229960004281 desmopressin Drugs 0.000 claims 3
- NFLWUMRGJYTJIN-PNIOQBSNSA-N desmopressin Chemical group C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-PNIOQBSNSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 230000001575 pathological Effects 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 229910001415 sodium ion Inorganic materials 0.000 claims 3
- VWXRQYYUEIYXCZ-OBIMUBPZSA-N Atosiban Chemical compound C1=CC(OCC)=CC=C1C[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)CSSCCC(=O)N1 VWXRQYYUEIYXCZ-OBIMUBPZSA-N 0.000 claims 2
- 229960002403 Atosiban Drugs 0.000 claims 2
- NSTRIRCPWQHTIA-DTRKZRJBSA-N Carbetocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSCCCC(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(OC)C=C1 NSTRIRCPWQHTIA-DTRKZRJBSA-N 0.000 claims 2
- 229960001118 Carbetocin Drugs 0.000 claims 2
- 101710008205 OXT Proteins 0.000 claims 2
- 102100017240 OXT Human genes 0.000 claims 2
- 229960001723 Oxytocin Drugs 0.000 claims 2
- XNOPRXBHLZRZKH-DSZYJQQASA-N Oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 2
- 210000002381 Plasma Anatomy 0.000 claims 2
- 229960004824 Triptorelin Drugs 0.000 claims 2
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 2
- 101700057139 oxyT Proteins 0.000 claims 2
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 claims 2
- 229960003726 vasopressin Drugs 0.000 claims 2
- GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 claims 1
- 229960002845 Desmopressin Acetate Drugs 0.000 claims 1
- BENFXAYNYRLAIU-QSVFAHTRSA-N Terlipressin Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CN)CSSC1 BENFXAYNYRLAIU-QSVFAHTRSA-N 0.000 claims 1
- 108010010056 Terlipressin Proteins 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- YNKFCNRZZPFMEX-XHPDKPNGSA-N desmopressin acetate trihydrate Chemical compound O.O.O.CC(O)=O.C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 YNKFCNRZZPFMEX-XHPDKPNGSA-N 0.000 claims 1
- 229960003813 terlipressin Drugs 0.000 claims 1
Claims (17)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US084,563 | 1993-06-29 | ||
US08/084,563 US5482931A (en) | 1993-06-29 | 1993-06-29 | Stabilized pharmaceutical peptide compositions |
US084.563 | 1993-06-29 | ||
PCT/SE1994/000622 WO1995001185A1 (en) | 1993-06-29 | 1994-06-22 | Stabilized pharmaceutical peptide compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
RU96102017A true RU96102017A (en) | 1998-03-27 |
RU2140281C1 RU2140281C1 (en) | 1999-10-27 |
Family
ID=22185761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96102017A RU2140281C1 (en) | 1993-06-29 | 1994-06-22 | Aqueous solution for nasal injection of biologically-active peptide, and sealed container |
Country Status (20)
Country | Link |
---|---|
US (1) | US5482931A (en) |
EP (1) | EP0710122B1 (en) |
JP (1) | JP3795520B2 (en) |
KR (1) | KR100195323B1 (en) |
CN (1) | CN1109558C (en) |
AT (1) | ATE210462T1 (en) |
CA (1) | CA2166296C (en) |
CZ (1) | CZ283186B6 (en) |
DE (1) | DE69429431T2 (en) |
DK (1) | DK0710122T3 (en) |
ES (1) | ES2168301T3 (en) |
FI (1) | FI117544B (en) |
HK (1) | HK1000903A1 (en) |
HU (1) | HU220044B (en) |
NZ (1) | NZ268441A (en) |
PL (1) | PL184437B1 (en) |
PT (1) | PT710122E (en) |
RU (1) | RU2140281C1 (en) |
SK (1) | SK281470B6 (en) |
WO (1) | WO1995001185A1 (en) |
Families Citing this family (61)
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US5763398A (en) * | 1996-06-20 | 1998-06-09 | Ferring B.V. | Nasal administration of desmopressin |
US5916582A (en) * | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
US5922680A (en) * | 1996-10-23 | 1999-07-13 | Ferring, B.V. | Stabilized composition for oral administration of peptides |
US7153845B2 (en) * | 1998-08-25 | 2006-12-26 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US8765177B2 (en) * | 1997-09-12 | 2014-07-01 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US6979442B1 (en) | 1998-08-17 | 2005-12-27 | Pfizer Inc. | Stabilized protein compositions |
US6187332B1 (en) * | 1999-06-14 | 2001-02-13 | Wisconsin Alumni Research Foundation | Acidic buffered nasal spray |
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JP2001233787A (en) * | 2000-02-04 | 2001-08-28 | Patents Exploitation Co Bv | Small-and medium-sized peptide-containing pharmacological composition |
EP1121935B1 (en) * | 2000-02-04 | 2008-08-13 | Patents Exploitation Company B.V. | Pharmaceutical composition containing a small or medium size peptide |
AT409081B (en) * | 2000-02-16 | 2002-05-27 | Gebro Pharma Gmbh | STABLE, NASAL, ORAL OR SUBLINGUAL APPLICABLE PHARMACEUTICAL PREPARATION |
GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
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CN100411683C (en) | 2002-05-21 | 2008-08-20 | 阿斯比奥制药株式会社 | Medicinal compositions containing ghrelin |
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US7094545B2 (en) | 2003-04-30 | 2006-08-22 | Ferring Bv | Pharmaceutical composition as solid dosage form and method for manufacturing thereof |
ATE301990T1 (en) | 2003-07-25 | 2005-09-15 | Ferring Bv | PHARMACEUTICAL DESMOPRESSIN PREPARATION AS A SOLID DOSAGE FORM AND METHOD FOR THEIR PRODUCTION |
US20050058673A1 (en) * | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
PT1530967E (en) * | 2003-11-13 | 2006-09-29 | Ferring Bv | PACKAGING BLISTER AND A SOLID DOSAGE FORM WHICH UNDERSTANDS DESMOPRESSIN. |
US7018653B2 (en) | 2003-12-29 | 2006-03-28 | Ferring B.V. | Method for preparing solid dosage form of desmopressin |
EP1800689B1 (en) | 2004-08-24 | 2016-12-28 | Daiichi Sankyo Company, Limited | Liquid preparation of physiologically active peptide |
US8198326B2 (en) * | 2004-09-07 | 2012-06-12 | 3M Innovative Properties Company | Phenolic antiseptic compositions and methods of use |
US9028852B2 (en) | 2004-09-07 | 2015-05-12 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
US20060051384A1 (en) * | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Antiseptic compositions and methods of use |
CN101107013A (en) * | 2004-11-22 | 2008-01-16 | 阿纳迪斯有限公司 | Bioactive compositions |
US10918618B2 (en) * | 2005-03-10 | 2021-02-16 | 3M Innovative Properties Company | Methods of reducing microbial contamination |
MX2007010908A (en) * | 2005-03-10 | 2007-12-05 | 3M Innovative Properties Co | Antimicrobial compositions comprising esters of hydroxycarboxylic acids. |
CN101137359B (en) * | 2005-03-10 | 2011-01-12 | 3M创新有限公司 | Methods of treating ear infections |
US20060287243A1 (en) * | 2005-06-17 | 2006-12-21 | Navneet Puri | Stable pharmaceutical compositions including motilin-like peptides |
US20060293243A1 (en) * | 2005-06-17 | 2006-12-28 | Navneet Puri | Stable, buffered, pharmaceutical compositions including motilin-like peptides |
SE528446C2 (en) * | 2006-03-02 | 2006-11-14 | Ferring Int Ct Sa | Pharmaceutical composition comprising desmopressin, silica and starch |
US9023793B2 (en) | 2006-09-29 | 2015-05-05 | Retrophin, Inc. | Intranasal carbetocin formulations and methods for the treatment of autism |
CA2667307C (en) | 2006-10-27 | 2015-12-01 | 3M Innovative Properties Company | Antimicrobial compositions comprising a c2-c5 lower alcohol, a cationic antimicrobial agent, and a fatty component containing free hydroxyl groups |
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ES2319054B1 (en) * | 2007-08-06 | 2010-02-12 | Gp Pharm S.A. | ORAL PHARMACEUTICAL COMPOSITION OF DESMOPRESINA. |
EP2197532A1 (en) | 2007-08-06 | 2010-06-23 | Serenity Pharmaceuticals Corporation | Methods and devices for desmopressin drug delivery |
US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
WO2009143356A1 (en) * | 2008-05-21 | 2009-11-26 | Ferring International Center S.A. | Orodispersible desmopressin for increasing initial period of sleep undisturbed by nocturia |
US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
EP2161030A1 (en) * | 2008-09-09 | 2010-03-10 | Rijksuniversiteit te Groningen | Oxytocin formulations and uses thereof |
AU2010260211B2 (en) | 2008-12-22 | 2016-04-21 | Acerus Pharmaceuticals USA, LLC | Safe desmopressin administration |
JO3400B1 (en) * | 2010-09-30 | 2019-10-20 | Ferring Bv | Pharmaceutical composition of carbetocin |
CN102440957B (en) * | 2011-12-16 | 2013-09-25 | 深圳市健元医药科技有限公司 | Terlipressin acetate nasal cavity spray and preparation method thereof |
CN103830720A (en) * | 2014-03-25 | 2014-06-04 | 深圳翰宇药业股份有限公司 | Medicine composition containing oxytocin |
RS65034B1 (en) | 2015-01-07 | 2024-02-29 | Tonix Pharma Ltd | Magnesium-containing oxytocin formulations and methods of use |
US9744239B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9744209B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9750785B2 (en) | 2015-01-30 | 2017-09-05 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US11318183B2 (en) | 2018-03-20 | 2022-05-03 | Mankind Pharma Ltd. | Stable pharmaceutical composition of vasopressin |
CN112969449A (en) * | 2018-06-15 | 2021-06-15 | 费灵有限公司 | Terlipressin composition and application thereof |
WO2020061414A1 (en) | 2018-09-20 | 2020-03-26 | Levo Therapeutics, Inc. | Stable intranasal formulations of carbetocin |
CN112969450B (en) | 2018-09-20 | 2023-05-30 | 阿卡蒂亚药品公司 | Carbetocin pharmaceutical product and process for preparing the same |
US20220080023A1 (en) * | 2018-12-21 | 2022-03-17 | Arecor Limited | Novel composition |
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-
1993
- 1993-06-29 US US08/084,563 patent/US5482931A/en not_active Expired - Lifetime
-
1994
- 1994-06-22 JP JP50342595A patent/JP3795520B2/en not_active Expired - Fee Related
- 1994-06-22 AT AT94920617T patent/ATE210462T1/en active
- 1994-06-22 EP EP94920617A patent/EP0710122B1/en not_active Expired - Lifetime
- 1994-06-22 WO PCT/SE1994/000622 patent/WO1995001185A1/en active IP Right Grant
- 1994-06-22 HU HU9503842A patent/HU220044B/en unknown
- 1994-06-22 PL PL94312203A patent/PL184437B1/en unknown
- 1994-06-22 DE DE69429431T patent/DE69429431T2/en not_active Expired - Lifetime
- 1994-06-22 CZ CZ953391A patent/CZ283186B6/en not_active IP Right Cessation
- 1994-06-22 PT PT94920617T patent/PT710122E/en unknown
- 1994-06-22 DK DK94920617T patent/DK0710122T3/en active
- 1994-06-22 CN CN94192595A patent/CN1109558C/en not_active Expired - Lifetime
- 1994-06-22 NZ NZ268441A patent/NZ268441A/en not_active IP Right Cessation
- 1994-06-22 ES ES94920617T patent/ES2168301T3/en not_active Expired - Lifetime
- 1994-06-22 RU RU96102017A patent/RU2140281C1/en active
- 1994-06-22 CA CA002166296A patent/CA2166296C/en not_active Expired - Lifetime
- 1994-06-22 KR KR1019950706029A patent/KR100195323B1/en not_active IP Right Cessation
- 1994-06-22 SK SK1651-95A patent/SK281470B6/en not_active IP Right Cessation
-
1995
- 1995-12-28 FI FI956310A patent/FI117544B/en not_active IP Right Cessation
-
1997
- 1997-12-22 HK HK97102552A patent/HK1000903A1/en not_active IP Right Cessation
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