RU95122160A - METHOD OF OBTAINING NG-MONOALKYL-L-ARGININE AND RELATED COMPOUNDS - Google Patents
METHOD OF OBTAINING NG-MONOALKYL-L-ARGININE AND RELATED COMPOUNDSInfo
- Publication number
- RU95122160A RU95122160A RU95122160/04A RU95122160A RU95122160A RU 95122160 A RU95122160 A RU 95122160A RU 95122160/04 A RU95122160/04 A RU 95122160/04A RU 95122160 A RU95122160 A RU 95122160A RU 95122160 A RU95122160 A RU 95122160A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- substituent
- compound
- takes
- pharmaceutically acceptable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 12
- 239000004475 Arginine Substances 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 5
- KFSLWBXXFJQRDL-UHFFFAOYSA-N peracetic acid Chemical group CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
Claims (8)
или его фармацевтически приемлемой соли или эфира, где заместитель R1 представляет собой С1 - С6-алкил и n принимает значения от 3 до 5, который включает взаимодействие гуанилирующего реагента формулы (II)
где заместитель R1 принимает значения, определенные выше,
с соединением формулы (III)
или его фармацевтически приемлемой солью или эфиром, где n принимает значения, определенные выше, в присутствии неорганического основания.1. The method of obtaining the compounds of formula (I)
or its pharmaceutically acceptable salt or ether, where the substituent R 1 represents a C 1 - C 6 -alkyl and n takes values from 3 to 5, which includes the interaction guanilating reagent of the formula (II)
where the substituent R 1 takes the values defined above,
with a compound of formula (III)
or a pharmaceutically acceptable salt or ester thereof, where n is as defined above, in the presence of an inorganic base.
где заместитель R1 принимает значения, определенные выше, который включает окисление соединения формулы (IV)
где заместитель R1 принимает значения, определенные выше, а окисляющий агент представляет собой надуксусную кислоту.7. The method of obtaining the compounds of formula (II)
where the substituent R 1 takes the values defined above, which includes the oxidation of compounds of formula (IV)
where the substituent R 1 takes the values defined above, and the oxidizing agent is a peracetic acid.
где заместитель R1 принимает значения, определенные выше, который включает окисление соединения формулы (IV)
где окисляющий агент представляет собой надуксусную кислоту, и затем в присутствии неорганической кислоты взаимодействие с соединением формулы (III)
где n принимает значения, определенные выше, причем способ проводят без выделения каких-либо промежуточных продуктов.8. The method of obtaining the compounds of formula (I)
where the substituent R 1 takes the values defined above, which includes the oxidation of compounds of formula (IV)
where the oxidizing agent is a peracetic acid, and then in the presence of an inorganic acid, the interaction with the compound of the formula (III)
where n takes the values defined above, and the method is carried out without isolating any intermediate products.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9309321-9 | 1993-05-06 | ||
| GB939309321A GB9309321D0 (en) | 1993-05-06 | 1993-05-06 | Process for the preparation of ng-monoalkyl-l-arginine derivatives |
| PCT/GB1994/000966 WO1994026701A1 (en) | 1993-05-06 | 1994-05-05 | Process for preparing ng-monoalkyl-l-arginine and related compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU95122160A true RU95122160A (en) | 1997-11-27 |
| RU2128166C1 RU2128166C1 (en) | 1999-03-27 |
Family
ID=10735020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95122160A RU2128166C1 (en) | 1993-05-06 | 1994-05-05 | Method of preparing amino acid n-monoalkyl derivatives and method of preparing n-alkyl-aminoiminomethanesulfonic acid |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5840972A (en) |
| EP (1) | EP0696274B1 (en) |
| JP (1) | JPH08509970A (en) |
| KR (1) | KR960701832A (en) |
| CN (1) | CN1122595A (en) |
| AT (1) | ATE187164T1 (en) |
| AU (1) | AU684080B2 (en) |
| CA (1) | CA2162155A1 (en) |
| CZ (1) | CZ286895A3 (en) |
| DE (1) | DE69421916D1 (en) |
| FI (1) | FI955282A (en) |
| GB (1) | GB9309321D0 (en) |
| HU (1) | HU216815B (en) |
| NO (1) | NO954410D0 (en) |
| NZ (1) | NZ265658A (en) |
| PL (1) | PL311582A1 (en) |
| RU (1) | RU2128166C1 (en) |
| SG (1) | SG49904A1 (en) |
| SK (1) | SK138295A3 (en) |
| WO (1) | WO1994026701A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240010627A1 (en) * | 2021-01-07 | 2024-01-11 | Peptidream Inc. | Novel guanidine derivative and method for producing same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1587258A (en) * | 1977-06-17 | 1981-04-01 | Gea As | Production of substituted guanidines |
| US4656291A (en) * | 1985-03-15 | 1987-04-07 | Mcneilab, Inc. | Process for producing amidine sulfonic acids |
-
1993
- 1993-05-06 GB GB939309321A patent/GB9309321D0/en active Pending
-
1994
- 1994-05-05 CZ CZ952868A patent/CZ286895A3/en unknown
- 1994-05-05 WO PCT/GB1994/000966 patent/WO1994026701A1/en not_active Application Discontinuation
- 1994-05-05 US US08/549,795 patent/US5840972A/en not_active Expired - Fee Related
- 1994-05-05 CN CN94192013A patent/CN1122595A/en active Pending
- 1994-05-05 JP JP6525115A patent/JPH08509970A/en active Pending
- 1994-05-05 SG SG1996008759A patent/SG49904A1/en unknown
- 1994-05-05 DE DE69421916T patent/DE69421916D1/en not_active Expired - Lifetime
- 1994-05-05 CA CA002162155A patent/CA2162155A1/en not_active Abandoned
- 1994-05-05 NZ NZ265658A patent/NZ265658A/en unknown
- 1994-05-05 RU RU95122160A patent/RU2128166C1/en active
- 1994-05-05 PL PL94311582A patent/PL311582A1/en unknown
- 1994-05-05 KR KR1019950704820A patent/KR960701832A/en not_active Application Discontinuation
- 1994-05-05 AT AT94914463T patent/ATE187164T1/en not_active IP Right Cessation
- 1994-05-05 EP EP94914463A patent/EP0696274B1/en not_active Expired - Lifetime
- 1994-05-05 HU HU9503164A patent/HU216815B/en not_active IP Right Cessation
- 1994-05-05 AU AU66824/94A patent/AU684080B2/en not_active Ceased
- 1994-05-05 SK SK1382-95A patent/SK138295A3/en unknown
-
1995
- 1995-11-03 NO NO954410A patent/NO954410D0/en unknown
- 1995-11-03 FI FI955282A patent/FI955282A/en unknown
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