DE59107784D1 - Codein salt of a substituted carboxylic acid, process for its preparation, its use and pharmaceutical preparations - Google Patents

Codein salt of a substituted carboxylic acid, process for its preparation, its use and pharmaceutical preparations

Info

Publication number
DE59107784D1
DE59107784D1 DE59107784T DE59107784T DE59107784D1 DE 59107784 D1 DE59107784 D1 DE 59107784D1 DE 59107784 T DE59107784 T DE 59107784T DE 59107784 T DE59107784 T DE 59107784T DE 59107784 D1 DE59107784 D1 DE 59107784D1
Authority
DE
Germany
Prior art keywords
salt
preparation
codein
carboxylic acid
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE59107784T
Other languages
German (de)
Inventor
Walter Dr Riess
Afred Dr Sallmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of DE59107784D1 publication Critical patent/DE59107784D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to the codeine salt of [2-[(2,6-dichlorophenyl)-amino]-phenyl]-acetic acid of formula <IMAGE> (I) to processes for the preparation thereof, to pharmaceutical compositions comprising that salt, and to its use as an analgesic drug. Compositions comprising the salt of formula I are used especially in the case of severe painful conditions.
DE59107784T 1990-08-23 1991-08-14 Codein salt of a substituted carboxylic acid, process for its preparation, its use and pharmaceutical preparations Expired - Fee Related DE59107784D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH273590 1990-08-23

Publications (1)

Publication Number Publication Date
DE59107784D1 true DE59107784D1 (en) 1996-06-13

Family

ID=4240432

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59107784T Expired - Fee Related DE59107784D1 (en) 1990-08-23 1991-08-14 Codein salt of a substituted carboxylic acid, process for its preparation, its use and pharmaceutical preparations

Country Status (20)

Country Link
US (1) US5190947A (en)
EP (1) EP0472501B1 (en)
JP (1) JPH04257587A (en)
KR (1) KR920004391A (en)
AT (1) ATE137753T1 (en)
AU (1) AU652951B2 (en)
CA (1) CA2049649A1 (en)
DE (1) DE59107784D1 (en)
DK (1) DK0472501T3 (en)
ES (1) ES2086515T3 (en)
FI (1) FI96421C (en)
GR (1) GR3019872T3 (en)
HU (1) HU209308B (en)
IE (1) IE72479B1 (en)
IL (1) IL99213A (en)
NO (1) NO179175C (en)
NZ (1) NZ239495A (en)
PT (1) PT98731B (en)
TW (1) TW225536B (en)
ZA (1) ZA916642B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE121724T1 (en) * 1991-02-07 1995-05-15 Heumann Pharma Gmbh & Co NEW SALTS OF 2-(2,6-DICHLORANILINO)-PHENYLESACETIC ACID, METHOD FOR THEIR PRODUCTION AND THEIR USE FOR TOPICALLY APPLICABLE PHARMACEUTICAL PREPARATIONS.
FR2708611B1 (en) * 1993-07-29 1995-10-27 Meram Lab Codeine salt of 2- (3-benzoylphenyl) propionic acid, process for obtaining it and pharmaceutical compositions containing it.
DE19607395C2 (en) * 1996-02-28 2002-11-21 Lohmann Therapie Syst Lts Salts from a cationic narcotic analgesic with an anionic non-narcotic analgesic, process for their preparation and the pharmaceutical preparations containing these salts
RS49982B (en) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Synergistic analgesic combination of opioid analgesic and cyclooxygenase-2 inhibitor
ID26296A (en) * 1997-09-25 2000-12-14 Lohmann Therapie Syst Lts SALT ADDITION OF ALORALOID MORPHIN AND ITS USE
AU2002305816B2 (en) * 2001-06-05 2008-04-10 Psivida Us Inc. Sustained-release analgesic compounds
JP2005518354A (en) * 2001-11-19 2005-06-23 コントロール・デリバリー・システムズ・インコーポレイテッド Pharmaceutical composition containing a codrug
US8840928B2 (en) * 2002-07-05 2014-09-23 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
AU2003247876B2 (en) 2002-07-05 2006-10-05 Collegium Pharmaceutical, Inc Abuse-deterrent pharmaceutical compositions of opiods and other drugs
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8557291B2 (en) 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
TW200500067A (en) * 2003-01-21 2005-01-01 Control Delivery Sys Inc Salts of codrugs and uses related thereto
WO2005123039A1 (en) 2004-06-12 2005-12-29 Collegium Pharmaceutical, Inc. Abuse-deterrent drug formulations
US20090291121A1 (en) * 2008-05-23 2009-11-26 Symrise, Inc. Capsule and coated capsules as a delivery system for dietary supplements and therapeutic materials
EP3417708B1 (en) 2009-03-12 2020-06-17 Cumberland Pharmaceuticals, Inc. Administration of intravenous ibuprofen
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2013112456A1 (en) 2012-01-24 2013-08-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Controlled release formulations for the induction and proliferation of blood cells
US9072710B2 (en) 2012-03-16 2015-07-07 Cumberland Pharmaceuticals Inc. Injectable ibuprofen formulation
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA537946A (en) * 1957-03-12 J. Lewenstein Mozes Process for preparing improved compounds having narcotic effect
US936254A (en) * 1908-01-06 1909-10-05 Belden Mfg Co Attachment for telephones.
DE377588C (en) * 1922-08-29 1923-06-22 O Hinsberg Dr Process for the preparation of a salt-like compound of codeine
US2628185A (en) * 1949-04-01 1953-02-10 Lewenstein Mozes Juda Analgesic compounds and compositions
US3895063A (en) * 1965-04-08 1975-07-15 Ciba Geigy Corp Substituted Anilino Benzyl Alcohols
FR2051482B1 (en) * 1969-04-04 1973-06-08 Rabot Ets David
CA964192A (en) * 1970-07-21 1975-03-11 Roy H. Reiner Long-acting narcotic antagonist formulations containing pamoate salts of dihydronormorphinone
FR2257606B1 (en) * 1974-01-10 1978-02-24 Sumitomo Chemical Co
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
DE2935776A1 (en) * 1979-09-05 1981-04-16 Theodor Prof. Dr. 4400 Münster Eckert Indomethacin, naproxen and diclofenac salts - with organic bases, esp. di:ethylamine, tri:ethanol-amine or tri:ethylamine
AT370721B (en) * 1981-02-24 1983-04-25 Ciba Geigy Ag METHOD FOR PRODUCING NEW SALTS OF 2- (2,6-DICHLORANILINO) -PHENYLACETIC ACID, THE
CH664085A5 (en) * 1985-02-08 1988-02-15 Ciba Geigy Ag PHARMACEUTICAL PREPARATIONS WITH ANALGETIC EFFECTIVENESS AND THEIR PRODUCTION.

Also Published As

Publication number Publication date
GR3019872T3 (en) 1996-08-31
NO179175C (en) 1996-08-21
ZA916642B (en) 1992-04-29
AU8268591A (en) 1992-02-27
IL99213A0 (en) 1992-07-15
JPH04257587A (en) 1992-09-11
PT98731A (en) 1992-07-31
FI96421C (en) 1996-06-25
AU652951B2 (en) 1994-09-15
NO913295D0 (en) 1991-08-22
FI913949A (en) 1992-02-24
NO913295L (en) 1992-02-24
EP0472501A2 (en) 1992-02-26
TW225536B (en) 1994-06-21
NO179175B (en) 1996-05-13
KR920004391A (en) 1992-03-27
EP0472501A3 (en) 1993-02-24
US5190947A (en) 1993-03-02
ATE137753T1 (en) 1996-05-15
PT98731B (en) 1999-01-29
HU912768D0 (en) 1992-01-28
ES2086515T3 (en) 1996-07-01
IL99213A (en) 1995-07-31
NZ239495A (en) 1997-05-26
DK0472501T3 (en) 1996-05-28
FI96421B (en) 1996-03-15
EP0472501B1 (en) 1996-05-08
IE912973A1 (en) 1992-02-26
FI913949A0 (en) 1991-08-21
HUT60501A (en) 1992-09-28
IE72479B1 (en) 1997-04-23
HU209308B (en) 1994-04-28
CA2049649A1 (en) 1992-02-24

Similar Documents

Publication Publication Date Title
DE59107784D1 (en) Codein salt of a substituted carboxylic acid, process for its preparation, its use and pharmaceutical preparations
GB2037745B (en) Diphenylbutyl - piperazinecarboxamides
DE69206214T2 (en) New arylethylamine derivatives, processes for their preparation and pharmaceutical compositions containing them.
ATE10626T1 (en) N-SUBSTITUTED OMEGA-(2-OXO-IMIDAZOLINE-1-YL)ALKANES[URIENES, THEIR SALTS AND ESTERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE ACTIVE SUBSTANCES.
ATE25246T1 (en) TRIPHENYLIMIDAZOLYLOXYALKANOIC ACIDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
DE19975059I2 (en) (2-Oxo-3-tetrahydrothienylcarbamoyl) -alkylthioacetic acid, its salts and esters, process for their preparation and medicaments containing them.
DE69409337D1 (en) Branched aminothiazole derivatives, processes for their preparation and pharmaceutical compositions containing them
ATE6640T1 (en) N-BENZOYL-ALPHA-ANILINOALKYLCARBOXYLIC ACIDS, THEIR SALTS AND ESTERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
PT76473B (en) SALICYLSAEUREDERIVATE PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE
RU98103388A (en) (R) -5-BROM-N- (1-ETHYL-4-Methylhexagidro-1H-1,4-Diazepin-6-IL) -2-METHOXI-6-M COMPOSITION CONTAINING THE SPECIFIED CONNECTION
DE59106966D1 (en) Process for the preparation of 3-amino-2- (het) aroyl-acrylic acid derivatives.
DE69209166T2 (en) Diclofenac choline salt, method of manufacture and pharmaceutical compositions containing it
DE58907678D1 (en) 6-fluoro-3,5-dihydroxycarboxylic acids and their derivatives, processes for their preparation, their use as pharmaceuticals, pharmaceutical preparations and intermediates.
ATE149T1 (en) 2-(N-(2&#39;-CHLORO-4&#39;-METHYLTHIENYL-3&#39;)-N-(CYCLOPROPYL-METHYL)-AMINO)-IMIDAZOLINE-(2), ITS ACID ADDITION SALTS, MEDICINAL PRODUCT CONTAINING THIS AND PROCESS FOR ITS PREPARATION.
ATE12649T1 (en) OPTICALLY ACTIVE DIPEPTIDE, ITS PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
ATE4204T1 (en) 2-(2-CHLORO-4-CYCLOPROPYL-PHENYL-IMINO)IMIDAZOLIDINE, ITS ACID ADDITION SALTS, PHARMACEUTICALS CONTAINING THEM, AND METHOD OF MANUFACTURE THE SAME.
JPS57142961A (en) Basic substituted anthranilic acid
ATE13181T1 (en) PYRIDAZINONEIMINE AND THEIR PHYSIOLOGICALLY TOLERABLE ACID ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THESE COMPOUNDS.
ES8306725A1 (en) N-Chlorocarbonyl-amino-acid esters, process for their preparation and their use.
ATE24712T1 (en) 1,3-BIS(DIMETHYLAMINO)-2-PROPYL-4CHLORPHENOXYACETATE, ITS ACID ADDITION SALTS, PROCESS FOR ITS PREPARATION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS.
RU93047670A (en) COMPOUNDS OF THE GENERAL FORMULA, METHODS OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION AND PESTICIDES ON THEIR BASIS

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8339 Ceased/non-payment of the annual fee