RU99122755A - METHOD OF OBTAINING COMPLEX ETHER 2-ALKYLIDENE-4-BROMACETOXIC ACID - Google Patents

METHOD OF OBTAINING COMPLEX ETHER 2-ALKYLIDENE-4-BROMACETOXIC ACID

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Publication number
RU99122755A
RU99122755A RU99122755/04A RU99122755A RU99122755A RU 99122755 A RU99122755 A RU 99122755A RU 99122755/04 A RU99122755/04 A RU 99122755/04A RU 99122755 A RU99122755 A RU 99122755A RU 99122755 A RU99122755 A RU 99122755A
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RU
Russia
Prior art keywords
acid
formula
carboxylic acid
amine
alkylidene
Prior art date
Application number
RU99122755/04A
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Russian (ru)
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RU2217412C2 (en
Inventor
Исао КУРИМОТО
Акихико НАКАМУРА
Норихико ХИРАТА
Original Assignee
Сумитомо Кемикал Компани, Лимитед
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Publication of RU99122755A publication Critical patent/RU99122755A/en
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Publication of RU2217412C2 publication Critical patent/RU2217412C2/en

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Claims (5)

1. Способ получения сложного эфира 2-алкилиден-4-бромацетоуксусной кислоты формулы 3:
Figure 00000001

где R1 и R2, каждый независимо друг от друга, представляют собой низшую алкильную группу с 1-5 атомами углерода, который предусматривает взаимодействие сложного эфира 4-бромацетоуксусной кислоты формулы 1:
Figure 00000002

где R1 имеет вышеуказанные значения, с альдегидом формулы 2:
R2CHO
где R2 имеет вышеуказанные значения, в инертном органическом растворителе в присутствии амина и карбоновой кислоты.1. The method of obtaining the ester of 2-alkylidene-4-bromoacetoacetic acid of formula 3:
Figure 00000001

where R 1 and R 2 , each independently of one another, represent a lower alkyl group with 1-5 carbon atoms, which provides for the interaction of the 4-bromoacetoacetic acid ester of the formula 1:
Figure 00000002

where R 1 has the above values, with an aldehyde of formula 2:
R 2 CHO
where R 2 has the above values, in an inert organic solvent in the presence of amine and carboxylic acid. 2. Способ по п. 1, в котором сложный эфир 4-бромацетоуксусной кислоты формулы 1, альдегид формулы 2 и амин одновременно добавляют к раствору карбоновой кислоты в инертном органическом растворителе. 2. The method according to claim 1, wherein the 4-bromoacetoacetic acid ester of formula 1, the aldehyde of formula 2 and the amine are simultaneously added to a solution of the carboxylic acid in an inert organic solvent. 3. Способ по п. 1, в котором сложный эфир 4-бромацетоуксусной кислоты формулы 1, альдегид формулы 2, амин и карбоновую кислоту одновременно добавляют к инертному органическому растворителю. 3. The method according to claim 1, wherein the 4-bromoacetoacetic acid ester of formula 1, the aldehyde of formula 2, the amine and the carboxylic acid are simultaneously added to an inert organic solvent. 4. Способ по п.1, в котором в качестве амина используют (C1-C20) вторичный амин, а в качестве карбоновой кислоты используют (С2-С6) карбоновую кислоту.4. The method according to claim 1, in which (C 1 -C 20 ) secondary amine is used as the amine, and (C 2 -C 6 ) carboxylic acid is used as the carboxylic acid. 5. Способ по п.4, в котором вторичным амином является пиперидин, а карбоновая кислота представляет собой уксусную кислоту. 5. The method according to claim 4, in which the secondary amine is piperidine, and the carboxylic acid is acetic acid.
RU99122755/04A 1998-11-02 1999-10-28 Method for preparing 2-alkylidene-4-bromoaceto- acetic acid ester RU2217412C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10-311939 1998-11-02
JP31193998 1998-11-02

Publications (2)

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RU99122755A true RU99122755A (en) 2001-07-27
RU2217412C2 RU2217412C2 (en) 2003-11-27

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US (1) US6469200B1 (en)
EP (1) EP0999202B1 (en)
CN (1) CN1158241C (en)
AT (1) ATE234806T1 (en)
CA (1) CA2287663C (en)
DE (1) DE69906009T2 (en)
ES (1) ES2198834T3 (en)
RU (1) RU2217412C2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102311345A (en) * 2010-09-09 2012-01-11 河北华戈化学集团有限公司 Continuous synthesis method of dimethyl acetylsuccinate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3037997A1 (en) * 1980-10-08 1982-05-13 Bayer Ag (BETA) LACTAMANTIBIOTICS, METHOD FOR THE PRODUCTION THEREOF AND MEANS CONTAINING THEM
IT1215298B (en) 1985-08-06 1990-01-31 Boehringer Biochemia Srl 2- (ETEROALCHIL) -1,4-DIHYDROPYRIDINE AND A PROCESS FOR THEIR PRODUCTION.
DE3541095A1 (en) * 1985-11-21 1987-05-27 Bayer Ag NEW CEPHALOSPORINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4921953A (en) * 1988-02-18 1990-05-01 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
MA21969A1 (en) 1989-10-05 1991-07-01 Beecham Group Plc PROCESS FOR THE PREPARATION OF NEW COMPOUNDS CONTAINING A BETA - LACTAM CYCLE.
IE65926B1 (en) * 1990-07-19 1995-11-29 Shionogi & Co Thioalkylthio cephalosporin derivatives
DE69911348T2 (en) * 1998-11-12 2004-07-15 Shionogi & Co., Ltd. Preparation of derivatives of 2-aminothiazole hydrobromide Z isomers

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